CRISPR: Prokaryotic Adaptive Immune System

(original figure)

The CRISPR-Cas9 system defends against phage and conjugative plasmid infection. First the cell incorporates the invading DNA into a CRISPR array. The cell uses the CRISPR elements to distinguish between genomic and invading DNA (Marraffini & Sontheimer, 2010). Next a CRISPR unit is transcribed to a CRISPR RNA (crRNA) and the crRNA is joined with a transactivating CRISPR RNA (tracrRNA) to form guide RNA (gRNA). The gRNA is bound by the Cas9 protein and causes  the enzyme to undergo a conformational change, which activates the two nuclease domains. This enzyme-RNA complex then catalyzes a double-strand break in the target DNA.

In the bacterial immune system, this process inhibits the viral infection. Researchers, however, can use this process to target and modify specific regions of host DNA.

 

78 Responses to CRISPR: Prokaryotic Adaptive Immune System

  1. Jesse says:

    Great work guys. This was very helpful and informative, I am thoroughly impressed.

  2. Info Hunter says:

    Well Said. Good article and right to the point. Thanks for this informative info

  3. Jenny says:

    Well said. Great work!

  4. Helpful article. Such articles make online reading worth for readers like us.

  5. Apk John says:

    Useful information about DNA thanks a lot.

  6. pUlr6W wow, awesome article post.Thanks Again. Great.

  7. Very good website you have here but I was wanting to know if you knew of any message boards that cover the same
    topics talked about in this article? I’d really
    like to be a part of group where I can get suggestions from other experienced people
    that share the same interest. If you have any recommendations, please let me know.
    Cheers!

  8. Thanks in favor of sharing such a good opinion, paragraph
    is good, thats why i have read it entirely

  9. I was wondering if you ever thought of changing the layout of your site?

    Its very well written; I love what youve got to say. But
    maybe you could a little more in the way of content so people could connect
    with it better. Youve got an awful lot of text for only
    having one or 2 pictures. Maybe you could space
    it out better?

  10. I pay a visit each day some web pages and blogs to read content, except this webpage provides feature based articles.

  11. It’s amazing designed for me to have a website, which is useful
    designed for my know-how. thanks admin

  12. What’s up, I desire to subscribe for this webpage to obtain most recent
    updates, thus where can i do it please assist.

  13. There is definately a great deal to find out about this topic.
    I like all the points you made.

  14. always i used to read smaller posts that as well clear their
    motive, and that is also happening with this article which I am reading now.

  15. Thanks for a marvelous posting! I seriously
    enjoyed reading it, you may be a great author.I will always bookmark your blog and definitely will come back at some point.
    I want to encourage you continue your great posts, have a nice weekend!

  16. I am really glad to read this weblog posts which consists of
    plenty of useful facts, thanks for providing these kinds of statistics.

  17. With havin so much content do you ever run into any problems
    of plagorism or copyright infringement? My blog has a lot of unique
    content I’ve either written myself or outsourced but it looks like a
    lot of it is popping it up all over the web without my agreement.
    Do you know any methods to help reduce content from being ripped off?

    I’d really appreciate it.

  18. Very nice write-up. I certainly appreciate this website.
    Keep it up!

  19. Very quickly this site will be famous amid all blogging and
    site-building viewers, due to it’s good posts

  20. This design is spectacular! You definitely know how to
    keep a reader entertained. Between your wit and your videos, I was
    almost moved to start my own blog (well, almost…HaHa!) Great
    job. I really loved what you had to say, and more than that, how you
    presented it. Too cool!

  21. Hello, everything is going fine here and ofcourse every one is sharing data,
    that’s truly fine, keep up writing.

  22. First off I want to say wonderful blog! I had a quick question in which I’d like to ask if you do not
    mind. I was curious to find out how you center yourself and clear your mind before writing.
    I’ve had a tough time clearing my thoughts in getting my thoughts out.
    I do take pleasure in writing but it just seems like
    the first 10 to 15 minutes tend to be lost simply just trying to figure out how to
    begin. Any suggestions or tips? Thank you!

  23. Oh my goodness! Amazing article dude! Thanks, However I am encountering problems with your RSS.
    I don’t understand why I can’t join it. Is there anyone
    else getting similar RSS problems? Anybody who knows the answer can you kindly respond?
    Thanx!!

  24. great points altogether, you simply won a logo new reader.
    What may you recommend in regards to your
    publish that you simply made a few days in the
    past? Any certain?

  25. David Johns says:

    This infographic helps understand easily. Overall good enough

  26. I am actually glad to read this blog posts which
    carries tons of valuable data, thanks for providing these information.

  27. Fine way of explaining, and good piece of writing to
    get data about my presentation subject matter, which i am going to
    present in academy.

  28. I was very pleased to uncover this page. I need to to thank you for ones time just for this wonderful read!!

    I definitely appreciated every bit of it and I have you book-marked to
    see new things on your site.

  29. Hello there, You’ve done a fantastic job. I will definitely digg it
    and personally recommend to my friends. I am confident they’ll
    be benefited from this website.

  30. of course like your web-site but you need to check the spelling on several of your posts.
    Several of them are rife with spelling problems
    and I in finding it very troublesome to tell the truth however I will surely come back again.

  31. Good respond in return of this matter with genuine arguments and telling the whole thing
    about that.

  32. Great article! We will be linking to this great content on our website.
    Keep up the great writing.

  33. What i don’t realize is in fact how you are not actually much more well-preferred than you may
    be right now. You are so intelligent. You already know thus considerably on the subject of this subject, made me in my opinion believe it from a lot of various angles.

    Its like men and women don’t seem to be fascinated until it’s one thing to do
    with Lady gaga! Your personal stuffs excellent. At all times
    handle it up!

  34. whoah this blog is magnificent i love reading your articles.
    Keep up the good work! You know, a lot of individuals are hunting around for
    this info, you can aid them greatly.

  35. 윈 토토 says:

    I got this site from my buddy who told me concerning this site and at the
    moment this time I am visiting this web page and reading very informative articles
    at this time.

  36. fantastic issues altogether, you simply received a new reader.

    What could you suggest in regards to your post that
    you simply made some days in the past? Any sure?

  37. Thanks for every other fantastic post. Where else may
    just anybody get that kind of information in such an ideal method of writing?
    I have a presentation subsequent week, and I am on the look for such information.

  38. Thank you a lot for sharing this with all of us you actually know what you’re talking approximately!
    Bookmarked. Please also seek advice from my website =).
    We could have a link alternate agreement between us

  39. First of all I want to say great blog! I had a quick question that I’d like to ask if you do not mind.
    I was curious to know how you center yourself and clear your head prior to writing.
    I have had a tough time clearing my thoughts in getting my ideas
    out. I truly do take pleasure in writing however it just seems like the first 10 to 15 minutes are generally wasted just trying to figure out how to begin. Any ideas or tips?

    Kudos!

  40. I’ve been absent for a while, but now I remember why I used to love this website. Thanks, I will try and check back more often. How frequently you update your site?

  41. Well said and used a nice infographic. It helps me to easy to understand

  42. Anonymous says:

    Thank you

  43. Jennifer says:

    I want to express my gratitude to this writer who writes very well and cover all the information on the topic.

  44. Geminair says:

    Wonderful post! Keep up the good writing. Thanks for sharing with us!

  45. wordpress says:

    Good post. I absolutely love this site. Keep it up!

  46. I express my thanks and gratitude to the writer and the website for uncovering vital information.

  47. Brasil says:

    I am impressed with your content and would like to say thanks for kindly sharing your knowledge with us.

    Best regards,

    Your follower

    Alex

  48. aryne says:

    Hi,
    Your posts are very instructive, which I later learned a lot from. It was great I hope you get more new posts! I am one of your Permanent Visitors

  49. Comfortfinds says:

    Great Post! Thanks for sharing with us.

  50. gek kar says:

    interesting information

  51. Thank you for sharing this interesting article with us, it is very explanatory!

    Regards

    Salvatore

  52. Very informative Blog!They provide the best information relevant this. One of the best services they provide till now.. Microsoft Azure Certifications, Azure Training, Microsoft Azure Training

  53. ISC888 says:

    Hi, I am Staff Website Promoter at MGWIN88
    the online market place resource for Telecom engineers and businesses and the Fastest Growing Start-up with a Global Workforce in 147 Countries .

  54. Charla says:

    Why users still use to read news papers when in this technological globe everything is existing on web?

  55. Lisa says:

    Thank you. Very clear.

  56. Nice blog! Keep sharing such an informative blog like this.

  57. 928bet says:

    You were great and everyone received so much from your experience and knowledge
    Absolutely amazing, thank you for sharing your knowledge with me.

  58. Alex says:

    What an amazing infographic! I also founded something interesting over here the training and certification courses to get trained on microtek training.

  59. Martin says:

    This blog really answered my questions!! I already bookmarked your website as the information which i was looking for i got it here. Know more about our best Microsoft SharePoint training that allows IT professionals to learn about
    sharepoint certification online

  60. What’s up, for all time i used to check blkg posts here inn the
    early hours in the break off day, since i enoy too learn more and more.

  61. David Ferris says:

    This is quite informative and interesting

  62. maruh sharma says:

    This blog really answered my questions!! I already bookmarked your website as the information which i was looking for i got it here. Know more about our best Microsoft SharePoint training that allows IT professionals to learn about
    https://getsugarbalances.com

  63. Well described! Keep up the good writing.

  64. thank you very much for kindly sharing this interesting article, hope to read more like this one.

    Regards

    Alex from Significado de Nomes para bebês: https://www.significadosnomes.com/2020/09/nomes-femininos-bonitos-para-bebes.html

    Take care

  65. nice article and blog, thanks a lot for sharing those informations with us

    Best regards

    take care

    Nomes para Cachorros: https://www.significadosnomes.com/2020/09/ideias-de-nomes-para-cachorros.html

    Jane

  66. Hi, I am the best top online casino web developer, I’m here to introduce myself. I am happy to stay here.

  67. miguel says:

    does this topic answer this question? “explain how components of CRISPR-Cas9 function in bacterial immunity”.

  68. MGWIN88 เว็บเดิมพันออนไลน์ สล็อตออนไลน์ บาคาร่าออนไลน์ เกมไพ่ แทงบอลออนไลน์ หวยออนไลน์ สูตรบาคาร่า ฟรีเครดิต 30% ค่าคอมมิชชั่น เยอะ และ ดีที่สุดอันดับ 1 ใน เอเชีย LINE @MGWIN

  69. You provide one of the best information which I was searching for that really help me a lot for this. I also found something interesting over here. Well, if you are seeking any beneficial information just find it Here

  70. Very interesting. I have never heard of it. I am very pleased to find this web-site. Thanks for sharing.

  71. I appreciate your skills and style in elaborating on the topic. It bound the reader for long. I have liked everything that I have read in the article so far. Nice content.

  72. Bhavlo says:

    Very helpful article, thanks Ankit. I am waiting for your next amazing blogging secret article. Well done My Friend….

Leave a Reply

Your email address will not be published.

Looking for something?

Use the form below to search the site:


Still not finding what you're looking for? Drop a comment on a post or contact us so we can take care of it!

Visit our friends!

A few highly recommended friends...

    Archives

    All entries, chronologically...

    Set your Twitter account name in your settings to use the TwitterBar Section.