Xu’s PNAS Paper Demonstrates Efficient Delivery of Genome-Editing Proteins Using Lipid Nanoparticles

Qiaobing Xu, Biomedical Engineering

A central challenge to the development of protein-based therapeutics is the inefficiency of delivering proteins across the cell membrane. Assistant Professor Qiaobing Xu is the co-author on a paper in the Proceedings of the National Academy of Sciences that demonstrated delivery of genome-editing proteins into cultured human cells with 70% efficacy comparable with or exceeding other commercially available systems. Xu and Ming Wang, postdoctoral scholar and first author, and collaborators also demonstrated that these lipids are effective for functional protein delivery for murine gene recombination in vivo. Xu’s lab will now pursue studies to better assess toxicity.

Leave a Reply

Your email address will not be published. Required fields are marked *