Nikhil Nair, assistant professor of biomedical engineering, received an NIH Director’s New Innovator Award for his research on engineering bacteria to treat inborn errors of metabolism (IEMs). These rare genetic disorders, like Phenylketonuria and Maple Syrup Urine Disorder, are disorders in which the body converts nutrients from food into harmful toxins. If not treated at birth, IEMs can impede intellectual or physical development and may even lead to death.
Nair and members of his synthetic biology laboratory are modifying lactobacillus bacteria that could produce enzymes that intercept and detoxify amino acids before they can be improperly metabolized to harm patients with IEMs.
The NIH Director’s New Innovator Award, established in 2007, supports early career investigators within 10 years of their terminal degree or clinical residency and is part of the NIH Common Fund’s High-Risk, High-Reward Research program.