Publications

2014

Pitts J.D., Klabis J., Richards A.L., Smith G.A., and Heldwein E.E. (2014). Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking. J. Virol. [Epub ahead of print] PMID: 24599989.

Stampfer S.D. and Heldwein E.E. (2014). Expression, Purification, and Crystallization of HSV-1 Glycoproteins for Structure Determination. Methods Mol. Biol. 1144, 249-263. PMID: 24671689.

 

2013

Silverman J.L. and Heldwein E.E. (2013). Mutations in the cytoplasmic tail of HSV-1 gH reduce the fusogenicity of gB in transfected cells. J. Virol. 87, 10139-47. PMID: 23843635.

Stampfer S.D. and Heldwein E.E. (2013). Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry. Curr. Opin. Virol. 3, 13-19. PMC3562363.

Vitu E., Sharma S., Stampfer S.D., and Heldwein E.E. (2013). Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form. J. Mol. Biol. 425, 2056-2071. PMC3655159.

Sharma S., Wisner T.W., Johnson D.C., and Heldwein E.E. (2013). HCMV gB shares structural and biochemical properties with gB proteins from other herpesviruses. Virology 435, 239-249. PMC3534942.

 

2012

Silverman J.L., Greene N.G., King D.S., and Heldwein E.E. (2012). Membrane requirement for the folding of the HSV-1 gB cytodomain suggests a unique mechanism of fusion regulation. J. Virol. 86, 8171-8184. PMC3421659.

 

2011

Eisenberg R.J., Heldwein E.E., Cohen G.H., and Krummenacher C. Recent progress in understanding herpes simplex virus entry: relationship of structure to function. In: “Alpha Herpesviruses: Molecular Virology”, S.K. Weller, Ed. Caister Academic Press. March 2011.

Cairns T.M., Whitbeck J.C., Lou H., Heldwein E.E., Chowdary T.K., Eisenberg R.J., and Cohen G.H. (2011). Capturing the herpes simplex virus core fusion complex (gB-gH/gL) in an acidic environment. J. Virol. 85, 6175-6184. PMC3126480.

 

2010

Stampfer S.D., Lou H., Cohen G.H., Eisenberg R.J., and Heldwein E.E. (2010). Structural basis of local, pH-dependent conformational changes in glycoprotein B from Herpes Simplex virus 1. J. Virol. 84, 12924-12933. PMC3004323.

Chowdary T.K., Cairns T.M., Atanasiu D., Cohen G.H., Eisenberg R.J., and Heldwein E.E. (2010). Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL. Nat. Struct. Mol. Biol. 17, 882-888. PMC2921994.

Chowdary T.K. and Heldwein E.E. (2010). Syncytial phenotype of HSV-1 gB is associated with diminished membrane interactions. J. Virol. 84, 4923-4935. PMC2863819.

Silverman J.L., Sharma S., Cairns T.M., and Heldwein E.E. (2010). Fusion-null insertion mutants of HSV-1 gB adopt the trimeric postfusion conformation. J. Virol. 84, 2001-2012. PMC2812406.

 

2009

Heldwein E.E. (2009). Entry of herpesviruses into cells: more than one way to pull the trigger. Structure. 17, 147-149.

 

2008

Heldwein E.E. and Krummenacher C. (2008). Entry of herpesviruses into mammalian cells. Cell. and Mol. Life Sciences 65, 1653-1668.

 

2007

Hannah B.P., Heldwein E.E., Bender F.C., Cohen G.H., and Eisenberg R.J. (2007). Mutational Evidence of Internal Fusion Loops in HSV glycoprotein B. J. Virol. 81, 4858-4865.

Bender F.C., Samanta M., Heldwein E.E., deLeon M.P., Lou H., Bilman E., Whitbeck J.C., Eisenberg R.J., and Cohen G.H. (2007). Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions. J. Virol. 81, 3827-3841.

 

2004-2006

Heldwein E.E., Lou H., Bender F.C., Cohen G.H., Eisenberg R.J., and HarrisonS.C. (2006). Crystal structure of glycoprotein B from Herpes Simplex Virus 1. Science 313, 217-220.

Heldwein E.E., Macia E., Wang J., Yin H.L., Kirchhausen T.K., and Harrison S.C. (2004). Crystal structure of the clathrin adaptor AP-1 core. Proc. Natl. Acad. Sci. USA 101, 14108-14113.

Heldwein E. This one goes to eleven (hundred) – data collection on crystals with a very long unit cell. CHESS News Magazine 2004:58-60.

 

1996-2002

Godsey M.H., Heldwein E.E., and Brennan R.G. (2002). Structural biology of bacterial multidrug resistance gene regulators. J. Biol. Chem. 277, 40169-40172.

Heldwein E.E. and Brennan R.G. (2001). Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature 409, 378-382.

Zheleznova E.E., Crosa J.H., and Brennan R.G. (2000). Characterization of DNA and metal binding properties of Vibrio anguillarum Fur. J. Bacteriol. 182, 6264-6267.

Vazquez-Laslop N., Zheleznova E.E., Markham P.N., Brennan R.G., and Neyfakh A.A. (2000). Recognition of multiple drugs by a single protein: a trivial solution of an old paradox. Biochem. Soc. Trans. 28, 517-520.

Jardim A., Liu W., Zheleznova E., and Ullman B. (2000). Peroxisomal Targeting Signal-1 Receptor Protein PEX5 from Leishmania donovani. MOLECULAR, BIOCHEMICAL, AND IMMUNOCYTOCHEMICAL CHARACTERIZATION. J. Biol. Chem. 275, 13637-13644.

Zheleznova E.E., Markham P.N., Edgar R., Bibi E., Neyfakh A.A., and Brennan R.G. (2000). A Structure-based Mechanism for Drug Binding by Multidrug Transporters. TiBS 25, 39-43.

Zheleznova E.E., Markham P.N., Neyfakh A.A., and Brennan R.G. (1999). Structural Basis of Multidrug Recognition by BmrR, a Transcription Activator of a Multidrug Transporter. Cell 96, 353-362.

Zheleznova E.E., Markham P.N., Neyfakh A.A., and Brennan R.G. (1997). Preliminary Structural Studies on the Multi-ligand Binding Domain of the Transcription Activator, BmrR, from Bacillus subtilis. Protein Science 6, 2465-2468.

Schumacher M.A., Zheleznova E.E., Poundstone K.S., Kluger R., Jones R.T., and Brennan R.G. (1997). Allosteric Intermediates Indicate R2 is the Liganded Hemoglobin End State. Proc. Natl. Acad. Sci. USA 94, 7841-7844.

Dement’eva E.I., Zheleznova E.E., Kutuzova G.D., Lundovskih I.A., and Ugarova N.N. (1996). Physicochemical Properties of Recombinant Luciferase Luciola mingrelica and its Mutant Forms [Russian]. Biokhimiia 61, 152-159.