Clinical Case Review

CURRENT STEM CELL RESEARCH

Andy Hoffman, D.V.M., D.V.Sc., D.A.C.V.I.M., Professor, Director, Lung Stem Cell Laboratory and Jose Garcia-Lopez, DVM, DACVS, Associate Professor.

The clinical scenario:

Charger, a 9-year-old Oldenburg gelding, presented to clinicians at the Hospital for Large Animals at the Cummings School of Veterinary Medicine at Tufts University for non-resolving hind limb lameness. During evaluation, Charger displayed excessive toe dragging of the rear limbs and abduction (outward swinging) of the right hind. When trotting, Charger exhibited a 2 out of 5 (0= sound; 5= non-weight bearing) right hind limb lameness, with a positive upper limb flexion test (indicating pain in the upper portion of the leg). Continue reading

Clinicians and Staff

CURRENT STEM CELL RESEARCH

José Garcia-Lopez – VMD, Diplomate ACVS

Dr. Garcia-Lopez

Dr. Garcia-Lopez

A fascination with equine athletes and sports medicine drew Dr. Jose Garcia-Lopez to join the faculty of the Cummings School of Veterinary Medicine and its Hospital for Large Animals, where he specializes in lameness, orthopedic and respiratory surgery for its equine patients.

Dr. Garcia-Lopez’s areas of clinical expertise and interests include orthopedic and upper respiratory surgery, as well as innovative lameness evaluation using advanced imaging techniques such as nuclear scintigraphy, MRI and CT. He further focuses and advances novel treatment modalities, which include procedures using Stem-cell, PRP (Platelet Rich Plasma) and IRAP (Interleukin-1 Receptor Antagonist Protein) therapy. In addition, his area of research expertise includes development and testing of new instrumentation and implants used in equine orthopedic surgery. He continues to improve and develop new techniques and instrumentation which aid in management and treatment of fractures and joint injuries.

Andrew Hoffman – DVM, DVSc, Diplomate ACVIM

Dr. Hoffman

Dr. Hoffman

 

Dr. Andrew Hoffman is a Professor in the Department of Clinical Sciences and Director of Regenerative Medicine.   His research interests include the fundamental biology of stem and progenitor cells and their potential application in cell therapeutics.  Projects in the Regenerative Medicine Laboratory involve over 12 faculty and 5 trainees with a focus on the safety and efficacy of stem cells used for treatment of autoimmune diseases and traumatic injuries to tissues. “

Topics of Discussion

CURRENT STEM CELL RESEARCH

Andy Hoffman, D.V.M., D.V.Sc., D.A.C.V.I.M., Professor, Director, Lung Stem Cell Laboratory and Jose Garcia-Lopez, DVM, DACVS, Associate Professor.

Understanding Stem Cell Potency: Can the Veterinary Profession Do Better?

Stem cells have now captivated the veterinary profession and for good reason.  These cells produce a vast array of molecules that promote repair and regeneration of damaged tissue. The signals produced by stem cells are so numerous and complex that they cannot yet be reproduced in the laboratory.  Harnessing their potential is the central focus for many laboratories around the world. The hope is that stem cells will revitalize tissue in healing wounds, and reduce inflammation, fibrosis, and auto-immunity. It’s a tall order but there is good evidence from animal models that stem cells or their derivatives can accomplish these goals.  Continue reading