Windy’s Cough: Causes and Characteristics
For the past 4 years, Windy, a 12-year old Hanoverian mare, has had a mild cough whenever her barn was closed up against the cold in the winter. Last year, the cough did not go away – and even seemed to be worse during the hot, humid weather in the late spring and summer. The cough was now interfering with the horse’s work as a third-level dressage horse. Windy’s veterinarian had recommended treatment with dexamethasone, a corticosteroid. The medication seemed to help, but the cough came back as soon as the treatment was discontinued.
Windy came to the Hospital for Large Animals at Tufts University’s Cummings School of Veterinary Medicine for a more in-depth evaluation. On physical examination, Windy’s breathing rate was slightly higher than usual (about 20 breaths per minute). There was also a small trickle of white discharge from both nostrils. When we listened to the air moving through her trachea, or windpipe, we could hear a rattling noise–which suggested the presence of mucus in her airways.
We examined Windy further at the Tufts Lung Function Laboratory, the only one of its kind in the Northeast. Here, we were able to test the ability of Windy’s lungs to move air effectively through her airways (see lung function testing, in our “Innovation” section), and found that her baseline resistance was only slightly elevated, an indicator of mild airway narrowing. This was good news, as it suggested a lower level of lung dysfunction. To determine if Windy’s lungs were “twitchy,” or more responsive to stimuli as often seen in horses with inflammatory airway disease, we performed a histamine bronchoprovocation test. These results showed that Windy narrowed her airways when exposed to very low levels of histamine, a substance that may be released in the horse’s lung when it is irritated by a dusty environment or cold temperatures.
This image shows the cytology of a bronchoalveolar lavage (BAL or lung wash) from a horse with inflammatory airway disease (IAD). This horse has many mast cells, as well as neutrophils and particulates from exposure to barn dust.
To further characterize the degree and type of inflammation in Windy’s airways, we performed a bronchoalveolar lavage, or BAL, using a thin, 2.3-meter videoscope. After examining the larger airways, we infused sterile saline into the lower lung and quickly suctioned it back. This gave us a sample of the abnormal inflammatory cells and mucus that were causing Windy’s cough. Microscopic examination of the lung secretions showed a large amount of mucus and inflammatory cells, called neutrophils. Windy also had an elevated number of mast cells, another type of inflammatory cell that contributes to airway reactivity, or twitchiness (see image).