Tag Archives: notes from the north

Notes from the North – Happy Mother’s Day!

Anyone who has been to the supermarket or drug store in the last couple of weeks has been bombarded with commercial reminders that mother’s day is just around the corner. Flowers, mom mugs, and cards all vie for attention next to registers beckoning shoppers to make a purchase and check mother’s day responsibility off the to-do list. When I picked up a tea kettle printed with spring flowers for my own mother, I was thinking of it as a mechanism to express my gratitude for all the love and support she has lavished on me. Having recently produced my own offspring, however, I find myself reflecting on the truly amazing biological processes that must occur in order for us to be here to celebrate mother’s day. So in addition to thanking her for being the amazing person she is, I also thank her for embarking on an amazing biological adventure three decades ago.

The grind of assays, meetings, and deadlines often forces us to narrow our focus exclusively on our own little piece of the biological puzzle such that thinking about the larger pattern becomes overwhelming. This weekend I will be trying to contemplate the biology of motherhood with wonder and appreciation instead of my more typical bewilderment.

As med-bio researchers we are more attuned than most to the incredible number of steps that must take place in near perfect choreography for a healthy living organism to result. Dividing cells talk and cross-talk, differentiate at variable rates, and form functioning organs that allow the growing fetus to become more and more independent. For mammals, cross talk between the maternal system and the fetal system trigger additional developmental programs for lactation in mom that were arrested at puberty.  In the hood we are happy if we can get our cultures to remain viable for more than several months. With all the resources of a full organism, cells can still be fully functional decades later without resorting to preservation in liquid nitrogen!

Incidentally, there was a student at Stanford a few years back who was also moved by mother’s day to contemplate the science behind the celebration. He expressed his appreciation much more eloquently than I in a ballad that can be found here on YouTube.

This mother’s day take time to celebrate the positive impact your mother has had in your life and use it also as a day to celebrate eons of evolution that result in modern biology. And don’t forget father’s day and grandparent’s day too!

Notes from the North – Reporting at the Molecular Level

March’s Notes from the North article is written by guest writer Spencer Scott, a current member of the Liaw Lab at MMCRI and recent transplant to the field of molecular medicine. He worked for seven years in New York as a producer for NPR, CNN, and ABC and is now a pre-med post-baccalaureate studying Biochemistry at the University of Southern Maine. Spencer will be applying to M.D. programs this spring.
Spencer CNN

CNN cameraman Spencer Scott reporting on the blackout in Manhattan following Hurricane Sandy in 2012.

Spencer Scott

Tom McCarthey’s brilliant film Spotlight took best picture at the Oscars this year. In an age when news has become synonymous with 24-hour cable networks plastered with pundits and steadily declining newspaper readerships, Spotlight is an important homage to the important role of real journalism in American society. For over seven years I worked as an aspiring producer for outlets including NPR, CNN, and ABC. While I would never dream of comparing my young career to the work of the incredible reporters at the Globe’s investigative unit, there is still a common aspiration amongst all those who enter the field. As their name, “Spotlight,” implies, we wish to shine light where there once was darkness, to illuminate the unknown for the betterment of our society.

A little more than a year ago, I left the craft to which I had thought I would devote my life. I spent the final four months of my career in television news shooting a medical documentary series for ABC in three of Boston’s Level I trauma centers. It was there in those halls that I finally decided to follow in the foot steps of my mother, father, and brother, and pursue medicine. I left my work in television and returned to my home state to begin a post-baccalaureate pre-medical program at University of Southern Maine, which I will finish in May.

It may seem odd that the child of an orthopedic surgeon and emergency room physician grew up shying, if not flat out running, away from the sciences. I still struggle to answer that for myself. But the only answer I can give is that I didn’t think my mind was wired in that way. I loved history and language and stories, and when I thought I could help people by telling their stories, I believed I’d found my calling. I sold my first story to NPR when I was seventeen, an interview with an Iraq war veteran, only three years older than I was. He had nearly lost his life in an IED explosion in Fallujah, the shrapnel of which had torn through his throat, rendering his voice a quiet rasp. Because of my reporting, millions of “All Things Considered” listeners heard Cpl. Chris Kotch tell his story. It was a feeling that inspired the pursuits of the next decade of my life.

In fact, after all of my years working in the field, I’m still proudest of the reporting I did when I was just a kid in high school. None of the stories I told in my professional career carried the weight that my earliest, self-directed work did. Working for big networks, the feeling that you had helped someone share something vital, that you had illuminated what was once shrouded in darkness, became rare, especially for a young producer. But in Boston, as I watched the doctors in my camera’s viewfinder treating their patients I saw something so exhilarating. It may sound cliché, or like a line from “We Are the World,” but I saw people helping people, through my lens and live before my eyes. I do not mean to discount the importance of journalism, I believe steadfastly in the critical role it plays in our society. But for me, witnessing those human connections made walking away from the field easy. I knew my place lay on the other side of the lens where the help was delivered every day directly and in real time.

Back in Maine, I threw myself headlong into my studies. When I walked into my first class at USM (BIO 105 Cell & Molecular Biology) I didn’t yet know if I had a mind for science, but I was willing to do whatever it took. Fortunately, I soon learned that in academia, you can do whatever you set your mind to, as long as you are willing to put in the work and the passion is genuine. Finding science has been the most fulfilling and gratifying experience of my life and I have been rewarded for the work I’ve put into it. When I started my program a little over a year ago, I never could have dreamed that I would be interning at a place like Maine Medical Center Research Institute, involved in the incredible work its investigators perform every day. In one sense, my work at the Institute is the farthest I have yet strayed from the newsroom. Whether it is furiously scribbling down names of promoters or genes or antibodies to google, or looking at slides of fluoresced cells and western blots, every Monday lab meeting reminds me that I am not in Kansas anymore. But in another sense, the work of the researchers at MMCRI is akin to that original creed of the aspirant journalist. Science and research, like journalism, work to shed light where there once was darkness. Both disciplines endeavor to peer into the unknown and learn what lies within. Whether it be learning the struggle of an American veteran who can no longer sleep through the night, or learning the process by which the notch signaling pathway impacts the function of endothelial cells in vasculature, science and journalism share the understanding that we are all better off for knowing.

Notes from the North – Northern Networking

Teleconferencing from 100 miles away into classes, meetings, and extracurricular events is all well and good, but sometimes you just feel the need to practice schmoozing in person. The Sackler Graduate Student Council holds really relevant and useful networking events, and much of the content of these events can be taken advantage of through a teleconference connection, but it is hard to beat the rapport that is established when chatting, or bemoaning, face to face with colleagues over hors d’oeuvres. For anyone who does the bulk of their work away from the main campus of their organization it is imperative to find and cultivate local career enhancement resources. Not only does this give you access to opportunities in your local sphere, it also improves your connection with the members of the satellite facility.

For Sackler students studying at the Maine Medical Center Research Institute (MMCRI) in Scarborough, ME this resource is available in the form of the MMCRI Research Fellows Association (RFA). Because MMCRI is a relatively small institute, we currently have about twenty principal investigators, we have a fairly small number of postdoctoral fellows and even fewer graduate students at any given time. The RFA was originally founded to serve both groups and has recently expanded to serve non-faculty scientific staff and technicians as well. These groups share many of the same needs in terms of networking and professional development events, so the inclusiveness of the organization has worked well for us thus far.

The RFA leadership team and active members are constantly kept busy to ensure we are providing meaningful events each month. Here’s just a small taste of what we do:
• Increase MMCRI visibility in the community by sending members to participate in local career fairs and the Maine Science Festival

RFA members handing out treats at the 2015 Barbra Bush Children’s hospital costume parade
RFA members handing out treats at the 2015 Barbra Bush Children’s hospital costume parade

• Organize scientific talks from speakers suggested and voted on by RFA members
• Hold professional development workshops such as “Intro to LinkedIn” and “The Art of Schmoozing” lead by University of New England’s Career Services Coordinator, Jeff Nevers
• Maintain a library of material on resume writing, cover letter writing, grant writing, and networking advice
• Work closely with MMCRI and MMC Human Resources to utilize hospital resources such as MMC’s Training and Organizational Development department for the benefit of our members
• Poll members annually on which of their professional development needs are being met and which still need to be filled
One of our newest events is also one of my favorites. In the spirit of positive reinforcement we recognize and celebrate either a mentor or a pair of researchers (one technician and one academic) of the year. This occasion allows the RFA to show appreciation for mentors and colleagues who demonstrate superlative qualities. Appreciation in the case of researchers includes $500 from the RFA discretionary fund (supported by our fundraising efforts) to participate in further career enhancement.

Former RFA president Dave Kuhrt, PhD presenting the 2014 Mentor of the year certificate to Dr. Rob Smith
Former RFA president Dave Kuhrt, PhD presenting the 2014 Mentor of the year certificate to Dr. Rob Smith

MMCRI may be 100 miles away from the biotech hub that is Boston, but we’re no backwater slouches when it comes to career enhancement and professional development!

Notes from the North – MMCRI Open House

Guest Post by Jessica Davis-Knowlton

About two hours north of where you sit reading your InSight there is another site of Tufts scientific discovery waiting to greet you! Tufts Sackler and Tufts University Medical School have partnerships with institutes in Maine allowing students to experience research and medicine in a unique setting with a strong emphasis on collaboration. During the 3rd and 4th rotations, first year students in Sackler have the opportunity to rotate with faculty members at the

MMCRI aerial view
MMCRI aerial view

Maine Medical Center Research Institute (MMCRI) in Scarborough, Maine before joining the CMDB program or with faculty at Jackson Laboratories (Jax) in Bar Harbor, Maine before joining the Genetics program. For TUSM students in the Maine Track Program immersion in the particular challenges facing Maine physicians starts with brief stints to Maine in the first and second years followed by a 9-month Longitudinal Integrated Clerkship in the third year.

Enough background though; what is particularly exciting about Maine this November is that MMCRI will be holding their annual Open House on the 20th and all are encouraged visit! The Open

MMCRI open house 2014
MMCRI open house 2014

House is a great opportunity to investigate our cores (Transgenics and Gene Targeting, Histopathology and Antibody Production, Confocal Microscopy, Small Animal Imaging, Protein and Nucleic

MMCRI small animal imaging
MMCRI small animal imaging

Acid Analysis, Molecular Phenotyping, Physiology and Behavior, and Clinical and Translational Research Services/Tissue Bank), see posters from Tufts and UMaine MMCRI grad students, meet the faculty, tour the building, and of course see green mice.

For first year CMDB students coming to visit on the 20th I’d like to highlight the newest principal investigator to join MMCRI and Jumbo alum, Michaela Regan, PhD. Dr. Reagan has a B.S. in Engineering from Harvey Mudd College in Claremont, California and a Ph.D. in Biomedical Engineering from Tufts University in Medford, Massachusetts. During her graduate

Michaela Regan
Dr. Michaela Regan

research, Dr. Regan studied Breast Cancer Bone Metastasis by investigating mesenchymal stem cell (MSC) tumor homing and developed silk scaffold implants with therapeutic bone marrow MSCs that deliver anti-tumor proteins to breast tumors. Her post-doctoral fellowship was in the lab of Dr. Irene Ghobrial at the Dana-Farber Cancer Institute/Harvard Medical School where she focused on understanding how multiple myeloma cells manipulate their bone marrow niche to support their growth and cause osteolytic lesion formation. She developed a 3D model of inhibited osteogenesis in silk scaffolds and examined the roles of abnormally expressed microRNAs in MSCs in this process. She also developed bone-targeted, bortezomib-loaded nanoparticles to modulate the bone microenvironment and make it less receptive to cancer cell colonization. When you see Dr. Regan, ask her about her path to becoming a PI: it’s all about collaboration and networking folks!

MMCRI Lucy Liaw
Dr. Lucy Liaw & Collaborators

Collaboration is the name of the game up here in Maine, as research institutes scattered about the state are relatively small. As a fortuitous consequence, a culture of cooperativeness and the drive to reach far outside normal comfort zones to seek said cooperation has prevented research in Maine from becoming insular. As pressure by publishers for completeness and complexity in manuscripts mounts, partnerships between labs, and the skills to develop such partnerships, have become ever more indispensible.

Remember, Boston had more snow than Portland last year so don’t fear the “winter, still winter, almost winter, and road construction” description of seasons in Maine: come see the Maine-Tufts partnership in action!

Jessica Davis-Knowlton is a 3rd year CMDB student in the Liaw lab in MMCRI.  Her thesis work focuses on the role of Notch signaling in smooth muscle cells involved in atherosclerosis.