Tag Archives: scientists

Coffee & Conversation with Dr. Laverne Melón

Written by Alyssa DeLeoNEURCoffee & Conversation is a series of informal chats with women faculty on campus, hosted by Tufts GWiSE. 

Our last Coffee & Conversation of the year featured Dr. Laverne Melón, a post-doctoral fellow in the Maguire lab and a TEACRS scholar. She will joining Wesleyan University as a faculty professor in neuroscience in the Fall. Laverne was born in Trinidad and moved to New York when she was 10 years old. In high school, Laverne helped establish the science club, which she insists was the most poppin’ after school extracurricular at the time, and she knew she wanted to work in research before even knowing what that was. The science club gave her and her peers the chance to support each other in the search for research experiences and ultimately lead her to volunteer in a cancer genetics lab at Columbia University. As she reflects on her first experience in science, she also acknowledges that it was also her first exposure to the sexism and racism that exists in scientific institutions. It’s difficult to turn a blind eye to these situations when all you want to do is put your head down and do the work in front of you. But, she didn’t let this taint her passion for the field and her experiences spoke to her resilience, which would be noted by several scientists later in her career.

Laverne went on to earn a BA in neuroscience at Middlebury College, a MS in Behavioral Neuroscience at Binghamton, and a PhD in Addiction Neuroscience at IUPUI after her lab at Binghamton moved. She lost a Binghamton fellowship in the move and had to teach at IUPUI, which she found frustrating as anyone does when they’re forced to do something. However, Laverne began to enjoy the process and her career path in academia became increasing clear. Laverne has been a post-doc in Jamie Maguire’s lab for the last 4 ½ years studying effects of stress on reproductive health and the role of the GABAergic system in alcohol addiction. As she moved into her post-doctoral years, she was really fueled by a research question which she presented to Jamie along with some data to score her current position. Now, she’s fielding multiple offers for faculty positions and learning to navigate this new part of her career.

As always, we chatted about how early life experiences brought our guests to their current positions, how crucial the role of mentors played in this trajectory, and the vital importance of self-advocacy. But, we kept coming back to this idea of producing good, reproducible science and how that is only possible if the field really cared about the people behind the data. It’s no secret that scientific institutions have not been the best advocates for the health of their workforce. Levecque et al. published a study in May of 2017 reporting one in two PhD students experience psychological distress and 1/3 of graduate students are at risk for a psychiatric disorder. An online survey of graduate students in a recent March 2018 study by Evans et al. reports graduate students are more than six times as likely to experience depression and anxiety compared to the general population. SIX times! It’s exceeding clear that health of scientists across fields and levels are struggling in this environment. This begins by hiring scientists that are more than a good researcher, but are inspired teachers, passionate mentors, and expert managers who are in touch the health of their lab.

As Laverne is beginning the next chapter of her career, she’s considering taking on an administrative position as a director of inclusion and diversity in addition to her faculty appointment. She intends to use her status to implement institutional changes to allow for better science through caring, supporting, and mentoring the next generation of scientists. When Laverne started to work in science, she admitted she tried to assimilate as much as possible, but it gets exhausting. It’s difficult to integrate into establishments and systems that have been hostile to the existence of women and minorities in science while trying to stick it out until you can get to a position to make changes. She’s been able to tap into her mentoring network over the years for support and instructed us to be vulnerable in our insecurities to allow these organic mentorships to grow.

If you’re interested in getting involved with GWiSE, follow us on Twitter @TuftsGWiSE, like us on Facebook, or email us at tuftsbostongwise@tufts.edu. Our next Coffee & Conversation is October 19th, 2018 at 5PM in Jaharis 913.

Humans of Sackler: Becca Silver, “Enthusiasm was contagious (no pun intended)”

 

I’m Ila Anand, a fifth-year student in the Microbiology program. I’ve recently taken over the “Humans of Sackler” portion of the Newsletter, which was originally pioneered by Andrew Hooper. In this issue I had the honor of getting to know our GSC president, Rebecca Silver, better known as “Becca.” It was a delight sitting down with this die-hard Bruins fan and discussing a variety of topics—from finding out she loves butter pecan ice cream and Figaro’s to discovering how she first broke into science. I hope you enjoy our conversation and are better acquainted with our GSC president!

IA: Hi Becca! Let’s start with what were you doing before you started graduate school?

RS: I was having a good time in college at the University of Maine in Orono! Besides the academics, my favorite part of college was having my friends nearby and being able to spend time with them whenever I wanted. I had a pretty diverse group of friends in college and I still keep in touch with them. I’m originally from Portland, Maine and spending time with close friends was also a big part of my childhood. My favorite memories are from Fourth of July when my friends and I would hang out at a lake house. The lifestyle in Maine is generally much more slow-paced. That is actually one of the biggest differences I noticed when I started grad school—there’s much more of a “rush” in Boston compared to Portland, where the people are more laid-back.

IA: Sounds like there are definitely some cultural differences between the cities. Where else have you traveled to in the past?

RS: I’ve mostly traveled on the East coast. I’ve visited the majority of the North East and I’ve also visited Georgia and Florida. I’ve actually never traveled to the West Coast but if I had the opportunity to attend a conference I would totally go. I also really want to ski in the mountains of Colorado at some point in the future. Outside of the U.S. I’ve traveled to Canada and Bermuda. I visited Bermuda when I was fairly young (ten years old) and I vividly remember that time period because two weeks before the vacation I had pneumonia. At the time it was awful because I missed school and was trying to recover (I had a lot of Pediasure!), but in the end, because I also went on vacation, I ultimately took a month off of school and my teachers didn’t assign me any extra homework. You could say that was my first introduction to the infectious disease field!

 

IA: That does sound awful! So when did you actually become interested in pursuing research and studying science?

RS: Well, I was a bioengineer back in college and honestly pursuing research was a decision I made on the whim. I took an immunology elective class my junior year of college and quickly realized I really like immunology. The class was much more interesting than any of my bioengineering classes- the lectures were awe-inspiring! The professor really emphasized infectious disease clinical examples like super gross rashes all over the body, etc. The professor was so excited and his enthusiasm was contagious (no pun intended). After taking the class, that summer I took the GRE and applied for grad school the fall of my senior year. It was literally a 6-month turnaround from being a bioengineer to wanting to be an immunologist!

 

IA: What was your first experience working in a lab?

RS: My first experience doing lab work was during a Co-Op internship at Idexx, which is a veterinary biotech in Portland, ME. I interned at Idexx during the summer going into my junior year of college. I was involved in developing a lateral flow assay that is similar to an ELISA and this rapid immunoassay detected digging worms in infested dog feces. It was a triple detection assay so it was able to detect whipworm, roundworm, and hookworm. My internship involved developing positive and negative controls for the assay. My boss at Idexx played on the same recreational hockey team that I did in Maine and she was a Tufts alumnus. Later, when I decided I wanted to go to grad school, I reached out to her for a reference and she’s the one who influenced me to apply to and attend Tufts Sackler.

IA: That’s really neat that you play rec-hockey. How did you get into that? What else do you like to do outside of bench research?

RS: I picked up hockey in high school when I was fourteen. My friend asked me to try out for the school team because they needed more people and now it’s one my favorite activities to do. I currently play on a Greater Boston rec-team called South Shore Women’s Hockey League. We have a lot of fun! In addition to hockey, I like to run. I run with a group in Jamaica Plains called the Forest Hill Runners and my favorite spot to run is in Peters Hill in the Harvard Arboretum. It has the best view of the whole city, in my opinion. I also like to cook and play video games—specifically strategy games, like Civilization 6. As GSC president, I’ve also been heavily involved in planning the Sackler relays. Our plans are kind of top secret but I can tell you that this year we’re going to have relays in June rather than July and we’re going to have an awesome raffle. Of course, my favorite part about relays is winning- go Immunogenetics!

Notes from the North: Review of Online Course “Scientists Teaching Science”

Scientific graduate programs all over the country do a wonderful job training their students to become critical thinkers able to design experiments, write fellowship grants, write peer reviewed papers, and grasp complex scientific systems. Nearly all programs, however, struggle to provide career training. Traditionally, skills such as mentoring, teaching, and leadership have been learned by observing others. This has generated many excellent scientists, mentors, teachers, and leaders, but how many more could we have developed had students received directed training? And how much better would our current scientific leaders be had they not had to reinvent the wheel for themselves?

One of the dangers of requiring students to learn through osmosis is that we tend to recapitulate what we see, even if it is not the most effective method. Partly this is because many of us do find this an effective way of gaining skills and knowledge, but there is also a mentality of initiation: we had to struggle, the next generation should experience this too. There are many answers to this paucity of career development training, however, in the form of business clubs, student and postdoc association lead career workshops, and online extracurricular courses.

Some of us at Sackler interested in a teaching career have taken advantage of a short course entitled “Scientists Teaching Science” which teaches best practices in science education, based on the latest research on teaching and STEM ed sol logolearning by STEM Education Solutions (http://stem-k20.com/). This is a completely online course that runs about nine weeks with a different module every week. Depending on the week, the time commitment is about 3 hours per week for light weeks and as much as 8 hours per week on heavy weeks (depending on how assiduous a note taker you are when doing readings and how detailed you are in written assignments).

I found the intro to the course very illustrative and memorable. We were asked to read several articles on how science has traditionally been taught and how active learning has repeatedly been shown to improve learning outcomes, then Barbara Houtz started her own narrated lecture in the traditional “Sage on the Stage” style. My heart immediately sank as I envisioned the next nine weeks writing dense, jargon filled notes on topics that seemed esoteric and non-practical. This was not what I thought I was signing up for! Then she paused and asked the question, “what are you thinking?”

That’s when the real lecture began. The narrated lectures were fantastic! Available 24/7 and provided as both narration and transcript. Methods that make participants stop to think about what they are being told were used liberally to retain participant attention. This meant that we were being shown how to effectively employ all the skills we were being taught as they were being taught to us. The modules covered learning/teaching styles, generating effective assessments, Bloom’s Taxonomy of Learning, writing your teaching philosophy (a part of faculty application materials that I only learned about last year despite years of aspiration to teach), cultural awareness, active learning and inquiry based teaching, writing course objectives, teaching online, course development, and syllabus compilation. Each module was comprised of a narrated lecture, readings, and a written assignment or discussion board post requirement. Additional resources were also provided on the Virtual Learning Environment and Barbara Houtz frequently sent out class announcements about recent articles on STEM education and careers for PhDs.STEM

I embarked on this online only course with a great deal of trepidation. Would I have the self-discipline to keep up with the material? Would I feel comfortable reaching out to the instructor with questions and comments? The answer is that with the help of an instructor devoted to keeping her participants involved and getting the most out of her course I was able to gain practical teaching skills in a remarkably short time.

Educate & Communicate: A Science Activism Manifesto

Science is often thought of as a monolithic entity, but it is actually a complex composition of a discipline, an institution, and a community, all focused on finding truth and knowledge in data and the natural world. Science as a community consists of people of all ethnicities and from all socioeconomic classes; talent is found everywhere, and we as scientists do not and should not limit our number to those with a privileged pedigree. Science as an institution is a pillar of modern society, supporting and enabling growth and progress previously impossible to achieve. Science as a discipline is an investigative practice that demands rigor, critical analysis, and substantive evidence to support the conclusions that we draw from the data. Science as a discipline to formulate theory may be apolitical, but as an institution and a community that is an integral part of modern civic society, science cannot simply be an idle observer. Atrocities have been committed in the name of science when the idea of the pure monolith prevails and is exploited by political regimes to suppress minorities, such as the Tuskegee syphilis experiments and Nazi human trials. However, science has also been used to fight for the welfare of all people and to resist such regimes: Rachel Carson, Albert Einstein, Linus Pauling, Max von Laue all used their privilege as scientists to fight for justice and the greater good. While the scientific discipline provides a path for pure theory, we are human, each with our own biases that guide our investigation, influence our analysis, and may even blind us to the truth. Ultimately, the application of scientific theory to society bears the imprint of our ideas and our biases, and we as a community bear responsibility for the results. It is therefore imperative that we distinguish the apolitical discipline of science from the institution and community of science, which are a part of civic society and inherently political. We currently hold privileged positions in society that are at risk in the contemporary political climate. The defense of science is our moral and civic duty. Furthermore, in defending ourselves, we should also take a stand to give a voice to those who cannot do so for themselves.

It has been three weeks since President Trump has entered office. It has been three weeks of chaos and confusion. In these three weeks, President Trump’s actions have threatened to tear apart the fabric of American society, wrought and held together for so long by people of all ethnicities, sexual, religious and political orientations. However, whereas his actions have largely focused on promoting protectionist values, it also appears that he and his cabinet nominees are determined on ignoring scientific evidence and denying the real dangers of climate change, as well as showing utter disregard for environmental protection. Their plans to dismantle the Environmental Protection Agency, with the help of the Republican Party, and the threat to abolish the Endangered Species Act all point to their contempt towards protecting biodiversity, the very proof of evolution. Their intention to deregulate the pharmaceutical industry, under the illusion of lowering drug prices, will risk the lives of patients. Their attempts to champion creationism and intelligent design over evolution in public education will risk the credibility of scientific facts. Meanwhile, the House committee on science, space and technology appears more eager to accept the President’s words despite what multiple media outlets have to say in their defense, even as President Trump proclaims any media outlet as “fake news” if they fail to agree with him. In addition, Trump’s hobnobbing with the most prominent anti-vaxxer, Andrew Wakefield, should already raise concerns about how decades of public health work to minimize infectious diseases and maintain public support will be undermined because of his ideology, especially when the anti-vax movement is gaining momentum. Even further, his claims to “totally destroy” the Johnson Amendment, the law that upholds the separation of Church and State, also pose a major threat to the scientific endeavor.

The U.S.A, the country that still puts the highest amount of taxpayer money into scientific research compared to other Western nations, is currently being ruled by an administration that would rather shape policy based on pre-existing ideologies than hard evidence. Since this administration ignores scientific data regarding the dangers posed by climate change, restricts dissemination of scientific data to the populace who funded the research, subjects its doctors and scientists to a travel ban in the guise of “protectionism” when data clearly show that homegrown terrorists have caused far more deaths in the U.S. than immigrants from any of the seven countries on the ban list, it is our duty as scientists to stand up and take a stance. We can no longer afford to look away. We can no longer afford to remain in our comfortable positions as biomedical scientists whose careers are not currently threatened. We should use our privilege to stand up for those whose voices have been muted.

In these times when the foundations of the scientific community are threatened and evidence-based policies disregarded, the outpouring of support has solidified our unity. Already, scientists are taking action – a nation-wide and possibly global March for Science rally has been planned for April 22 (Earth Day). Prominent scientists across the U.S. have petitioned against the travel ban, and European scientists have offered laboratory space to scientists stranded due to the travel ban. Scientists from all walks of life are organizing to protect their communities; scientists are actively thinking about running for office and other positions to influence policy-making. These are all very encouraging, however, these actions are missing a key point – this is a battle of ideology, not policy or scientific literacy. As a recent study has shown, the public does not consider scientific questions that raise moral or ethical concerns as “science” questions. Another recent excellent article on how science journalism can combat this issue reports that science journalists should “listen, be curious and consider the non-science factors that shape people’s beliefs – because people’s beliefs shape policy, our society, and the world”. One may imagine that increasing scientific literacy should take care of such issues, however, that has not been the case. All too often, scientists  fail to properly communicate with the masses and are  unable to get the message across because they were too focused on explaining the basic science without taking into consideration the presentation of  facts.

This is not a temporary issue. Trump is not the only President who has or will challenge evidence-based policy and threaten the scientific community. However, it is crucial that we take action now because the dangers of climate change are imminent and we cannot afford to deny it anymore. Therefore, it is imperative that scientists come forward to educate and communicate with the public in a language and tone sufficient to start a dialogue. We start by communicating with each other, educating each other about our work. From there, we communicate and educate our family members and relatives, our friends, our communities and beyond. This has to be a grassroots movement – no top-down policy will fix the scientific literacy issue and lead American society toward a future where policies are based on hard evidence as  opposed to blind faith. This is how we can give back to the public, who provide the majority of funding for our work, and ensure that science does not belong to an elite population, but in the hands and minds of the people.

This is why we are calling on you, each and every scientist, ranging from technicians to postdocs, graduate students to faculty, to action. Educate and communicate with your science. Explain why it is necessary. Even if you talk to just one person a day, that can make a difference. That is where we start. If you want to do more, organize. Rally behind policymakers who heed scientific evidence and will champion such causes. Volunteer at high schools and colleges. Take part in science festivals. Celebrate science and its achievements sans the elitism. It is not about funding, or whose research is more important. It is about making science accessible to the masses, who have tirelessly supported and benefited from our work for decades and will continue to do so. It is about rescuing science from the clutches of political partisanship. It is about freedom to communicate our science, the protection of our community, and the advancement of our society.

For too long academics have been cooped up in their self-imposed exclusive isolation from the masses. For too long we have assumed that Science exists in a vacuum. We cannot afford this axiom anymore. We have to consider the social, political, and economic forces that affect the direction of scientific research. We have a moral and civic duty to fight for what is right and to prevent the use of science to advance fascist ideology. The time to take action is now. 

Here are some resources to help you take action in the short term –

Sincerely,

The Sackler Insight Team

Feature: Humans of Sackler

Do you have fun and interesting hobbies?  Have you traveled to fascinating places?  Held unusual and challenging jobs?  Do you use cutting-edge technology to conduct biomedical research of earth-shattering importance?  Are you a human?  If you answered “yes” to any of these, you could be the next Human of Sackler!

Humans of Sackler is a monthly blog featuring individual Sackler students’ firsthand accounts of their path to the Graduate Biomedical program.  Inspired by Brandon Stanton’s “Humans of New York” blog, the aims of this project are to highlight the Sackler School’s rich diversity of backgrounds, interests, and personalities, and to engage with the public by revealing the human side of scientists.

If you are interested in contributing to or nominating someone for the Humans of Sackler blog, contact Andrew Hooper (andrew.hooper@tufts.edu, Subject: Humans of Sackler) to set up a brief interview at your convenience.  We look forward to hearing your story!

Read the first issue here: Humans of Sackler, 25 July 2016

Humans of Sackler: Jaclyn Dunphy, “Good Things Come to Those Who Waitress”

I’m Andrew Hooper, a fourth-year student in Dr. Jamie Maguire’s lab in the Neuroscience program.  For as long as I can remember, I’ve been fascinated by the stories of how scientists came to be scientists.  Where are they from?  When did they recognize their passion for science?  How did they get their foot in the door?  What is it about their topic of interest that so captivated them?  And what breakthroughs just over the horizon would most excite them?  There are as many compelling, eye-opening answers to these questions as there are scientists, and I decided to highlight the diversity of backgrounds and perspectives at the Sackler School by gathering and sharing some of these stories.  Inspired by the format of Brandon Stanton’s wonderful “Humans of New York” blog, I called this project “Humans of Sackler”.

Recently I had the opportunity to sit down with Jaclyn Dunphy, a fourth-year Neuroscience student in Dr. Phil Haydon’s lab.  We discussed the questions above and many more, and I’m very happy to share with you a small sample of our conversation in this, the first issue of “Humans of Sackler”.  Enjoy, and please look me up if you’d like to share your story and be the next Human of Sackler!

 

Humans of Sackler, 15 June 2016

Jaclyn Dunphy, Neuroscience, Fourth-Year Student: “Good Things Come to Those Who Waitress”

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Graduating from the Masters program at Kent State NEOMED

AH: Did you come into college with a biology major, knowing that that’s what you wanted to study?

JD: I wanted to be a teacher when I started college because I had a really great biology teacher in high school. I went to Xavier, a private Catholic college, so I also thought I might want to be a religion teacher. For the first couple years I took biology, education classes, and theology classes. But I had a ‘coming to terms moment’ with what my major was going to be around sophomore year, and so I just went through the bulletin of all the courses that were offered and picked the ones I liked the best – and they tended to be related to biology, so I figured that’s what I should be doing. I didn’t know what I could do with the degree. I had never heard of graduate school until after I graduated!

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At an air show with dad

AH: Were your parents interested in science, or did your interest develop totally independently from family?

JD: I think my interest in science definitely goes back to roots that I have with my dad. He has a workbench in the basement, and some of my earliest memories of us spending time together were us building rockets in the basement. He was very into space and stuff, so we would build rockets down there. Also, I was in this program for gifted students when I was in fourth and fifth grade, and we were assigned weird projects – like if you’ve heard of the ‘egg drop’ project, where you have to drop an egg off of a roof and get it not to crack? I would get assignments like this and take them home. I was really excited about them, but my dad was even more excited! So we would work on those things together, and I would go back to school with something that was, like, 80% his idea and 20% mine. So in those couple of years we had five or six things we worked on together in the workshop downstairs, and that was really fun… We built a bridge with Popsicle sticks, and I could stand on it. I could stand on it to this day! We made I-beams – not my idea. I’d never heard of that, but he was like ‘We need to build I-beams!’ We even sanded them – it was intense.

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After a day of kayaking on the Charles

AH: After you finished undergrad, what did you do for work and how did you transition eventually to grad school?

JD: I was working at an upscale restaurant called Bistro on Main, close to Kent State’s campus, where Kent State professors take their seminar speakers out for dinner. So I had seen a couple groups of them come through, but one night I was waitressing for a table of four people: three people from NEOMED/Kent State and their invited speaker, Wendy Macklin. When I came to the table they were talking about prion disease, and I said, ‘Oh, that’s odd dinner conversation’. And they asked ‘How do you know what that is?’ in a very accusatory but jovial tone, and I said ‘Well, I just graduated with a degree in biology’ and they were like ‘Then what are you doing here?’ and I said ‘Waiting on you, what does it look like?’ So after that, all four of them took turns harassing me, they asked ‘Do you need a job?’ and I said ‘No, I have a great job, I’m making a lot of money doing this, I’m just trying to figure out what I want to do.’ And they said ‘Well, if you figure it out, then here’s my card.’ They put the card in the bill and they said, ‘Give us a call if you want to work as a technician.’ And I didn’t even know what that meant. At that point, I thought I was going to be cleaning rat cages. So I interviewed with one of the professors at the dinner, Bill Lynch, a few weeks later. It was the worst interview I’ve ever had, it was terrible! He’s a virologist: he asked me whether viruses are living or not. I didn’t know it at the time, but that’s a controversy among virologists. So I just picked a side, and then he argued me all around in circles until I switched sides, and then he asked me why I switched sides..! I left feeling so defeated; it was the first experience I’d had of someone who really, really questioned my thought process. I felt terrible, I felt like I had done such a bad job. But he ended up offering me the job because he liked that I didn’t give up, he liked my enthusiasm.

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Demonstrating the Blind Spot at the Museum of Science, with Alex Jones (right)

AH: What was it about glial cells that made them so interesting to you?

JD: I fell for astrocytes – I liked that they were so abundant but they were so under-studied. There was so much to learn. What are they doing? There has to be more to the story. Later on, when I met Phil Haydon, he said that in the field of glia, there’s a lot of low-hanging fruit, and I felt like that was very much the case. Glia are… I hate the word ‘support’ cells, but they are support cells for neurons. Neurons are like actors in the big play that is the brain, so the glia are stagehands, directors, producers, writers – they’re the ones that actually control the show. But the ones that you see and you care about are the neurons.