It’s been a while again – midterms put a damper on updating this site, but now that I’m done with that, I’m planning to start rifling through tons of papers – we’ve already found a couple things that we’re looking to talk about in our video that I’ll cover here, and once we have more information about the script and direction of our video I’ll be sure to update this website accordingly!
Firstly, we’ve shifted away from polymer and non-organic nanoparticles. There’s a not a lot of research dedicated to the edibility of these types of nanoparticles, which makes it difficult for us to figure out if it’s even possible to have targeted drug absorption and releasure. Plant-based nanoparticles, however, are inherently edible and relatively less toxic – and have been recently looked at as a possibility for nanovectors for biologically active components, which is exactly what our siRNA treatments aim to be. After doing some more paper research, we’ve found a couple of really interesting things that we plan to focus on going forward for our video and final presentation:
Firstly, plant-derived nanoparticles are nontoxic and relatively more hypoallergenic compared to other types of nanoparticles. This makes them a prime candidate for long-term, large-scale production as treatment, as the particles don’t need to be tailored to specific patients in the same vein as experimental cancer treatments today.
Secondly, plant-derived nanoparticles are already edible but have also been proven to be extremely effective as drug transport for chemotherapy drugs (and miRNA/siRNA, but we’re currently looking into the feasibility of these specifically), and are very effective in their staying power within the bloodstream.
We just need to hone in on siRNA targets to implant into our nanoparticles, but beyond that the majority of our research should be finished! I’ll update this post once more when we have that more concretely down, along with starting a script for our video!