The research at the integrated Biofunctional Imaging and Therapeutics Laboratory (iBIT Lab) focuses on utilizing non-invasive acoustic and optical imaging techniques with nanomaterials and biological models to understand the structural, functional, molecular and biomechanical heterogeneity of pathologies such as cancer. The triangle in the iBIT lab logo depicts the three directions where biofunctional imaging will be utilized to improve patient care: 1. Guide surgical methods 2. Predict therapeutic response and 3. Design effective therapeutic strategies.
We are a team of Biomedical engineers with interdisciplinary background in Electronics, signal processing, molecular biology, optics and nanotechnology with collaborations with clinicians and researchers in the Boston Area. We are always looking for enthusiastic highly motivated individuals to join our team. Check out the current openings here.
Publication on Frontiers in Placenta ImagingCheckout our review paper here, headed by Chris Nguyen, on placenta imaging with Dr. Mary Wallingford group! We are excited about this collaboration and new directions for photoacoustic and photodynamic therapy!
Study on LED-Photoacoustic Imaging for imaging tumor vasculature is now published
Access paper here. Traditionally photoacoustic systems employ expensive and bulky class IV lasers with low pulse repetition rate, due to which its availability for preclinical cancer research is hampered. In this study, we evaluated the capability of a Light-Emitting Diode (LED)-based PA and ultrasound (US) imaging system for monitoring heterogeneous microvasculature in tumors (up to 10 mm in depth) and quantitatively compared the PA images with gold standard histology images. Analysis of 30 regions of interest in tumors from different mice showed a statistically significant R-value of 0.84 where the areas with high blood vessel density had high PA response while low blood vessel density regions had low PA response. Our results confirm that LED-based PA and US imaging can provide 2D and 3D images of tumor vasculature and the potential it has as a valuable tool for preclinical cancer research.
NIH S10 Award for Dr. Mallidi
Dr. Mallidi has received an S10 award to setup a small animal imaging core at the Medford Campus! The first instrument in the core is FujiFILM VisualSonics Ultrasound and photoacoustic imaging instrument
Chris & Marvin pass Qualifiers
iBIT Labs first batch of graduate students- Chris Nguyen and Marvin Xavierselvan pass the PhD qualifiers! Congratulations!
We are on Tufts NEWS!
UG Kelsey Detels wins the Audrey Butvavy Gruss Science Award
Congratulations Kelsey!She won the Audrey Butvavy Gruss Science Award for Juniors/seniors for the year 2020. Awarded annually to a student who has demonstrated outstanding academic work in any of the sciences and who is a scholarship recipient. This award was established in 1992 by Audrey Butvay Gruss, an alumna of Jackson College. Working in the iBIT lab since last summer, Kelsey has been instrumental in helping with setting up the lab and the cell inventory for the lab. Read more about it here
Paper Published in Particle!
First paper of the collaboration with Dr. Michelle Foster at UMass Boston is now published in Particle . Here we utilized novel nanoparticles for image-guided drug delivery