Summer 2013

Tick, Tick, Tick

What looks like Lyme disease may be a completely different illness

By Lindsey Konkel

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Tufts Cummings School of Veterinary Medicine professor and tick expert Sam Telford shows off a few of his deer tick specimens. Photo: Kelvin Ma

Under the microscope, Sam Telford surveyed the tiny, spiral bacteria floating in spinal fluid taken from an 80-year-old woman. They looked very similar to the spirochete bacteria that can cause Lyme disease. But in fact, he had discovered yet another public health threat—a brand new disease that people can get from the same ticks that transmit the Lyme bacteria.

“We’ve known that this bacteria existed in the Northeast in deer ticks, but there was little data linking it to human disease” until now, says Telford, an expert on tick-borne illness and a professor in the Department of Infectious Diseases and Global Health at the Cummings School of Veterinary Medicine. “We just needed the right patient to confirm the presence of the disease.”

That patient was the elderly woman, who lived on a farm in New Jersey. Over four months, she had experienced progressive mental decline. Her gait grew wobbly, and she didn’t have much of an appetite. Her immune system was compromised from a previous bout with cancer, so her doctors drew spinal fluid to try to determine what was going on.

When technicians at a commercial diagnostic laboratory saw the mysterious spiral bacteria, they sent the sample to Telford, whose laboratory serves as a reference center for unusual zoonotic infections, that is, those that pass between animals and humans.

Telford and Heidi Goethert, J93, a microbiologist at the Cummings School, sequenced the spirochete DNA, and identified it as Borrelia miyamotoi, which was first found in ticks in Japan in 1995 and is closely related to the bug that causes Lyme disease. Previous cases of B. miyamotoi infections in people had been identified in Russia in 2011.

The Tufts scientists reported the first U.S. case of human B. miyamotoi infection in the New England Journal of Medicine in January. (The infected woman was treated with antibiotics and has since recovered.)

The B. miyamotoi bacteria may be an under-recognized source of human disease, especially in such regions as the northeastern United States, where Lyme disease is prevalent, say Telford and his coauthors.

There’s been lingering disagreement in the scientific and medical communities about whether a person can test negative for Lyme and still have Lyme, says Telford. This latest research raises the question of whether patients with atypical Lyme disease—those who have symptoms but whose blood doesn’t test positive for Lyme—may actually be infected with B. miyamotoi, he says.

While an estimated 12 to 18 percent of coastal New Englanders have been infected with the Lyme bacteria, called Borrelia burgdorferi, only between 1 and 3 percent of people have likely been infected with its lesser-known cousin, B. miyamotoi, researchers at Yale reported in commentary that accompanied the Tufts study in NEJM. The Yale team is led by Peter J. Krause, ’71, and also includes Timothy J. Lepore, ’70.

Not all deer ticks carry B. miyamotoi, just as they don’t all carry the Lyme-causing bacteria. This latest tick-borne disease, which has yet to be named, is the fifth known human infection to come from deer ticks in the Northeast, after Lyme, babesiosis, ehrlichiosis and deer tick virus.

Ticks are notorious transmitters of infectious diseases. Their indiscriminate dining habits (they don’t seem to care what animals they feed on) and the relatively large amount of blood they consume (200 times their own body weight) make them particularly adept at picking up pathogens and then spreading them.

“Lyme disease alone is enough of an argument to take action to reduce risks, let alone four other [tick-caused] infections,” says Telford. “In some New England communities, as many as a third of residents have been exposed to at least one tick-borne infection,” says Telford, who suggests that public education about tick-borne diseases and reducing deer herds, while controversial, may be a good place to start.

Lindsey Konkel is a freelance writer in Worcester, Mass.

 

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