Current Concepts

Oral Malignant Melanoma in Dogs and Cats

Melanoma is a tumor of melanocytes, which arise from neural crest cells and function to synthesize melanin. Melanocytes are commonly located in the oral cavity, haired skin and eye, making these the most common locations where melanomas arise. Biologic behavior of melanoma depends in part on tumor location. The majority of melanomas that arise in the oral cavity are classified both histologically and biologically as malignant. Histologic features that support a diagnosis of oral malignant melanoma include a mitotic index greater than 2 mitoses per 10 high-powered fields, nuclear atypia, vascular or lymphatic invasion and ulceration. Malignant tumors may be variably pigmented or amelanotic (one third of cases). Since melanocytes are derived from neural crest cells, which ultimately give rise to both glandular tissues and connective tissues, melanomas can resemble both carcinomas and sarcomas morphologically. Given these challenges to diagnosing a malignant melanoma, several immunohistochemical stains have been developed to aid in the diagnosis.  Melanomas typically stain positive for vimentin, melan A, S100, and neuron-specific enolase (NSE); these stains can be helpful in diagnosis. Continue reading

At Your Service

Tufts’ Clinical Oncology Team

The clinical oncology service at Tufts’ Foster Hospital is comprised of veterinary oncologists, residents and technicians who work together as a team.  The oncologists work closely with the surgery service, which has expertise in surgical oncology, as well as with the pathology, diagnostic imaging, interventional radiology and pain management services.  Through collaboration with these and other specialty services throughout the hospital, the oncology service provides a broad range of options for owners of companion animals with cancer. Continue reading

Innovation

Hypofractionated radiation therapy combined with the ONCEPT canine melanoma vaccine for canine oral melanoma

The Veterinary Radiation Therapy Oncology Group consists of a group of board-certified radiation oncologists across the nation dedicated to cooperative clinical trials to improve the survival of animals with cancer. The team at Tufts’ Foster Hospital for Small Animals is part of this consortium and is currently enrolling patients.  This organization is currently conducting an independent study to evaluate the treatment of canine oral malignant melanoma with coarse-fraction radiotherapy (8 Gy for 4 weekly fractions) in combination with the ONCEPT™ melanoma vaccine. Data for three treatment groups (concurrent radiation therapy and vaccine; radiation therapy alone; vaccine alone) will be collected.  Given that the study is not funded, treatment selection will be based on owners preference.  The primary objective of this study is to compare tumor progression between the treatment groups with a secondary objective of evaluating overall survival time. Continue reading

Clinical Case Challenge

Oral Mass in a Cat

History and Physical Exam:  An 11-year-old, castrated male domestic shorthair cat presented for evaluation of a rapidly growing mass along his left rostral maxilla. The owners reported that hyperemia of the mucus membranes had been noticed in that region at his annual physical exam by his local veterinarian.  The lesion progressed over the next 5 months and caused loosening of his maxillary canine and incisor teeth.  The cat also had a history of hypertrophic cardiomyopathy and hyperthyroidism.  Physical examination revealed an approximate 3.5 x 3 x 2 cm gingival mass in the left rostral maxilla displacing the lip.  Additional findings included loose teeth, blood-tinged saliva, a moderately enlarged left mandibular lymph node, a palpable thyroid slip and a grade III/VI heart murmur. Continue reading