Investigation of a novel diet for support of dogs undergoing chemotherapy for mast cell tumors or multicentric lymphoma

Cancer is one of the most common conditions seen in older dogs and it is becoming more common for owners to opt to treat their pets with chemotherapy. Dogs undergoing chemotherapy may suffer from side effects of treatment such as vomiting, diarrhea, and reduced appetite. There are currently no commercial diets that are designed specifically to help support dogs with cancer undergoing chemotherapy by reducing the gastrointestinal side effects of chemotherapy.

The purpose of the study is to determine whether a specially formulated diet may reduce gastrointestinal side effects associated with chemotherapy and improve the quality of life of dogs undergoing chemotherapy.

For more information regarding this study, please visit: http://sites.tufts.edu/vetclinicaltrials/specialty/nutrition/

Comprehensive Care for Dog with Cancer Includes Access to Innovative Clinical Trial

Background

When Brady, an 11-year-old, mixed breed yellow Labrador, presented to his primary care veterinarian with a lump on his right hind leg in May 2014, it did not appear to be anything of concern. However, after surgery and biopsy results, owner Kory Haag heard the words no pet owner wants to hear: Brady had a high- grade mast cell tumor and would have about six months to live. That was when Kory made an appointment with the oncology specialists at Foster Hospital to explore if there were other treatments they should pursue.

For Kory Haag, it was an instinctual decision to bring Brady to Foster Hospital. He had previously brought his dog there for the treatment of epilepsy and was pleased with the care received.

Treatment

Brady had the opportunity to see not one but two of the oncology residents, Kelly Kezer, BVSc, and Bobbi McQuown, DVM, who both consulted on his case. Testing was completed and Brady underwent further surgery to ensure all the cancer cells had been removed. Brady then received an injectable chemotherapy agent once a week for four weeks, which was administered on site at Foster Hospital. He was subsequently transitioned to an oral small molecule inhibitor that targets a mutation found to be present on Brady’s mast cell tumor. Individuals bring their pets to an academic veterinary medical center because they offer a comprehensive, one-stop resource for high-caliber, advanced and specialty veterinary services. That includes access to the latest research and leading edge treatments available.

For Brady, this presented an opportunity to take part in a study exploring the impact of a novel diet in dogs with cancer. Cancer is far too often diagnosed in older dogs and it is becoming more common for owners to treat their pets with chemotherapy. The goal of the study was to determine whether a specially formulated diet might reduce the gastrointestinal side effects that can accompany chemotherapy and improve their quality of life.

It was easy,” said Kory. “I merely filled out an enrollment form and was provided the food to feed Brady. It involved giving Brady a certain number of calories per day and was limited to specific treats. I also had to document what he ate as well as his bowel movements and it was all done online.”

Brady adapted well to the diet and easily transitioned to a commercial brand of food after the study was completed.

Outcome

It is now almost eight months since Brady’s cancer diagnosis and Brady has a new leash on life, enjoying a very active lifestyle with ongoing therapy. While the collective results of the diet study will not be available for another year, Brady’s ultrasounds and blood work have been consistently favorable. Dr. Kezer remarked at how amazed she is when she hears about the hikes that owner Kory and Brady continue to take, including mountain climbs.

And Kory can’t say enough about the caring staff at Foster Hospital. When he recently discovered another small lump on Brady’s leg in January, he grew concerned. Within two days, he was scheduled to see Dr. McQuown and fortunately it turned out to be just fatty tissue. He also commented on how accommodating the staff was in scheduling Brady’s chemotherapy since he was traveling from Holyoke.

As the only academic veterinary center in New England, we are dedicated to providing care in a compassionate environment to heal the animals we see each and every day. For Brady, that offered the chance to get all of his services in one place, including his surgery, chemotherapy administration and ongoing medical follow-up. What is highly encouraging for pet owners is the exploratory research studies that we offer that provide hope, a better quality of life and additional time that companion pets can spend with their families.

Meet the Clinical Studies Lab Technicians


Diane Welsh

Clinical Trial Technician

Welsh, Diane SM (2)Diane Welsh, is a certified veterinary technician with more than 30 years of experience in the field of animal medicine. After receiving her degree in veterinary technology from Becker Junior College, she spent 16 years working in private practice at Littleton Animal Hospital and
Abbott Animal Hospital prior to joining the team at Cummings School of Veterinary Medicine at Tufts University 17 years ago. She has held numerous roles during her tenure at Cummings School, from treating critically ill and emergency patients in the ICU and ER, performing hemodialysis treatments on renal service patients to being responsible for the Tufts University blood bank. Now as a clinical trial technician for the Department of Clinical Sciences, she spends more than half of her time focused on clinical studies in the Regenerative Medicine Laboratory and her remaining time with other clinical department studies. Outside of work, she enjoys sewing, reading and spending time with her family. While she has owned golden retrievers, cats and a rabbit over the years, she is currently on a break from pet ownership. In the meantime, she enjoys visiting her two “grandpigs,” (guinea pigs) that her son has at home.

Sarah Cass
Senior Research Technician

Cass, Sarah IDSarah Cass is no stranger to animal medicine, starting her work in small animal hospitals during her high school years. She went on to pursue her passion to care for animals, receiving an associate’s degree in veterinary technology, and subsequently a bachelor’s degree in veterinary medicine from Becker College in 2000. Since then her experience has included working as a technician in emergency practice, conducting genetic research and most recently joining the Department of Clinical Sciences at Cummings School of Veterinary Medicine at Tufts University in June 2014. As a senior research technician, Sarah is involved in all aspects of clinical research from laboratory work, hands-on activities with the animals and client owners, managing laboratory equipment to budgeting. In her free time, she enjoys being outdoors, whether it’s skiing, hiking, kayaking, biking, or gardening, as well as spending time with her seven-year-old daughter. Sarah doesn’t leave her interactions with animals behind at work where at home she cares for her family’s 13-year-old black lab, three-year-old boxer mix, two cats, a guinea pig, and some fish. You will soon find Sarah on the road meeting with referring veterinarians with the hope of generating interest and enrollment in the exciting and innovative clinical research efforts underway at Cummings School.