Innovation

High-Dose Cyclophosphamide Holds Promise for Dogs with Lymphoma

For decades, the cornerstone of treatment for dogs with lymphoma has been chemotherapy employing five drugs: cyclophosphamide, doxorubicin, vincristine, L-asparaginase and prednisone.  Efforts to optimize these protocols by adjusting the doses and scheduling of drugs have not yielded significant improvement in remission rates or survival times.  In addition, the realization that discontinuous short chemotherapy protocols are as effective as traditional long protocols that include a lengthy maintenance phase has provided the opportunity to search for novel therapies to combat lymphoma before overt chemotherapy resistance develops.

Alternative modalities that have been studied include radiation therapy, chemotherapy agents traditionally reserved for rescue therapy, monoclonal antibodies, dose-intensified chemotherapy and bone marrow transplantation.  These approaches have yielded variable results, and some promising findings are under continued investigation. Continue reading