Matlab offers a variety of Optimization functions in the Optimization and Statistics Toolboxes. One useful application for students is the Gui interface to nlinfit, called nlintool. This interactive graphical tool can be used for nonlinear least squares regression fitting and prediction for functions of one or more variables and parameters. As with all such tools, your mileage will vary depending on needs and data formats. The strength of this tool and interface is the relative ease of use and default outputs. The typical workflow setting is in the support of lab data analysis. You can investigate the nlinfit and nlintool documentation via the DEMOs help browser.
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