Cross-Over Designs have played a major role in applied settings that cuts across so many disciplines. And there is a rich history and literature on the topic. I recently acquired: Design and Analysis of Cross-Over Trials, Second Edition, by Byron Jones and Michael G. Kenward, Chapman & Hall/CRC PRESS. In keeping with the spirit of this blog, I would like mention that the authors provide their SAS code that accompanies their excellent text. As one can see, many solutions are cast in the Mixed Model framework offering covariance structures and estimation options that allow the most flexibility for modeling simple to advanced Cross-Over Designs. The codes are available here.
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