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Pluripotent stem cells self-renew extensively and give rise to multiple cell types of therapeutic significance. Our laboratory investigates the molecular determinants of stem cell commitment along particular lineages, mainly to heart muscle and pancreatic endocrine insulin-producing cells. Additionally, our efforts concentrate on the scalable expansion and differentiation, which are prerequisites for the realization of stem cell-based applications envisioned in regenerative medicine and tissue engineering. Experiments are coupled to multiscale stochastic models for describing, predicting and optimizing the phenotypic outcome in stem cell populations under various contexts in vitro and in vivo.

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Last updated: 01/2017