Publications

Selected Publications

  1. Chen, Z., Downing, S., Tzanakakis, E.S., Four decades after the discovery of regenerating islet-derived (Reg) proteins: Current understanding and challenges, Front. Cell Dev. Biol., 2019 (accepted).
  2. Zhang, F., Tzanakakis, E.S., Amelioration of diabetes in a murine model upon transplantation of pancreatic β-cells with optogenetic control of cyclic AMP, ACS Synth. Biol., 2019.
  3. Downing, S., Zhang, F., Chen, Z., Tzanakakis, E.S., MicroRNA-7 directly targets Reg1 in pancreatic cells, Am. J. Physiol. Cell Physiol., 317(2):C366-C374, 2019.
  4. Jacobson, E.F., Tzanakakis, E.S., Who will win: Induced pluripotent stem cells versus embryonic stem cells for β-cell replacement and diabetes disease modeling?, Curr. Diab. Rep., 18:133, 2018.
  5. Zhang, F., Tzanakakis, E.S., Optogenetic regulation of insulin secretion in pancreatic β-cells, Sci. Rep., 7(1):9357, 2017.
  6. Jacobson, E.F., Tzanakakis, E.S., Human pluripotent stem cell differentiation to functional pancreatic cells for diabetes therapies: Innovations, challenges and future directions, J. Biol. Eng., 11:21, 2017.
  7. Fan, Y., Zhang, F., Tzanakakis, E.S., Engineering xeno-free microcarriers with recombinant vitronectin, albumin and UV irradiation for human pluripotent stem cell bioprocessing, ACS Biomater. Sci. Eng., 3(8):1510-18, 2017.
  8. Ashok, P., Fan, Y., Rostami, M.R., Tzanakakis, E.S., Aggregate and microcarrier cultures of human pluripotent stem cells in stirred-suspension systems, Methods Mol. Biol., 1502:35-52,2016.
  9. Rostami, M.R., Wu, J., Tzanakakis, E.S., Inverse problem analysis of pluripotent stem cell aggregation dynamics in stirred-suspension cultures, J. Biotechnol., 208:70-9, 2015.
  10. Parikh, A., Wu, J., Blanton, R., Tzanakakis, E.S., Signaling pathways and gene regulatory networks in cardiomyocyte differentiation, Tissue Eng. Part B Rev., 21(4):377-92, 2015.
  11. Terranova, C., Narla, S.T., Lee, Y-W., Bard, J., Parikh, A., Stachowiak, E.K., Tzanakakis, E.S., Buck, M.J., Birkaya, B., Stachowiak, M.K., Global developmental gene programming involves a nuclear form of Fibroblast Growth Factor Receptor-1 (FGFR1), PLOS One, 10(4):e0123380, 2015.
  12. Wu, J., Fan, Y., Tzanakakis, E.S., Increased culture density is linked to decelerated proliferation, prolonged G1 phase and enhanced propensity for differentiation of self-renewing human pluripotent stem cells, Stem Cells Dev., 24(7):892-903, 2015.
  13. Fan, Y., Wu, J., Ashok, P., Hsiung, M., Tzanakakis, E.S., “Production of human pluripotent stem cell therapeutics under defined xeno-free conditions: Progress and challenges“, Stem Cell Rev., 11(1):96-109, 2015.
  14. Wu, J., Rostami, M.R., Cadavid Olaya, D.P., Tzanakakis, E.S., Oxygen transport and stem cell aggregation in stirred-suspension bioreactor cultures, PLOS One, 9(7):e102486, 2014.
  15. Fan, Y., Hsiung, M., Cheng, C., Tzanakakis, E.S., Facile engineering of xeno-free microcarriers for the scalable cultivation of human pluripotent stem cells in stirred suspension, Tissue Eng., 20(3-4):588-99, 2014.
  16. Chen, C.K., Law, W.C., Aalinkeel, R., Yu, Y., Nair, B., Wu, J., Mahajan, S., Reynolds, J.L., Li, Y., Lai, C.K., Tzanakakis, E.S., Schwartz, S.A., Prasad, P.N., Cheng, C., Biodegradable cationic polymer nanocapsules for overcoming multidrug resistance and enabling drug-gene co-delivery to cancer cells, Nanoscale, 6(3):1567-72, 2014.
  17. Tzanakakis, E.S., Hu, W.S., Stem cell science has made major strides in the last few years. Introduction., Biotechnol. Adv., 31(7): 993, 2013.
  18. Wu, J., Tzanakakis, E.S., Deconstructing stem cell population heterogeneity: Single-cell analysis and modeling approaches, Biotechnol. Adv., 31(7): 1047-62, 2013.
  19. Bett, G.C.L., Kaplan, A.D., Lis, A., Cimato, T., Tzanakakis, E.S., Zhou, Q., Morales, M.J., Rasmusson, R.L., Electronic ‘expression’ of the inward rectifier in cardiomyocytes derived from human induced pluripotent stem cells, Heart Rhythm 10(12):1903-10, 2013.
  20. Wu, J., Tzanakakis, E.S., Distinct allelic patterns of Nanog expression impart embryonic stem cell population heterogeneity, PLOS Comp. Biol., 9(7):e1003140, 2013.
  21. Wu, J., Rostami, M.R., Tzanakakis, E.S., Stem cell modeling: from gene networks to cell populations,Curr. Opin. Chem. Eng., 2(1):17-25, 2013.
  22. Mann, J.K., Wood, J.F., Stephan, A.F., Tzanakakis, E.S., Ferkey, D.M., Park, S., Epitope guided engineering of protein binders for in vivo inhibition of ERK-2 signaling, ACS Chem. Biol., 8(3):608-16, 2013.
  23. Stachowiak, M.K., Kucinski, A., Curl, R., Syposs, C., Yang, Y., Narla, S., Terranova, C., Prokop, D., Klejbor, I., Bencherif, M., Birkaya, B., Corso, B., Parikh, A., Tzanakakis, E.S., Wersinger, S., Stachowiak, E.K., Schizophrenia: A neurodevelopmental disorder – integrative genomic hypothesis and therapeutic implications from a transgenic mouse model, Schizophrenia Research, 143(2-3):367-76, 2013.
  24. Wu, J., Tzanakakis, E.S., Contribution of stochastic partitioning at human embryonic stem cell division to NANOG heterogeneity, PLoS ONE, 7(11):e50715, 2012.
  25. Lee, Y.W., Terranova, C., Birkaya, B., Narla, S., Kehoe, D., Parikh, A., Dong, S., Ratzka, A., Brinkmann, H., Aletta, J.M., Tzanakakis, E.S., Stachowiak, E.K., Claus, P., Stachowiak, M.K., A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during gene programming of embryonic stem cells, J. Cell Biochem., 113(9):2920-36, 2012.
  26. Patil, S.A., Chandrasekaran, E.V., Matta, K.L., Parikh, A., Tzanakakis, E.S., Neelamegham, S., Scaling down the size and increasing the throughput of glycosyltransferase assays: Activity changes on stem cell differentiation, Anal. Biochem., 425(2):135-144, 2012.
  27. Parikh, A., Stephan, A.F., Tzanakakis, E.S., Regenerating proteins and their expression, regulation and signaling, Biomol. Concepts, 3(1):57-70, 2012.
  28. Lock, L.T., Laychock, S.G., Tzanakakis, E.S., Pseudoislets in stirred-suspension culture exhibit enhanced cell survival, propagation and insulin secretion, J. Biotechnol., 151(3):278-86, 2011.
  29. Jing, D., Parikh, A., Tzanakakis, E.S., Cardiac Cell Generation from Encapsulated Embryonic Stem Cells in Static and Scalable Culture Systems, Cell Transplant., 19(11):1397-1412, 2010.
  30. Jing, D., Kehoe, D.E., Tzanakakis, E.S., Expression of Reg Family Proteins in Embryonic Stem Cells and its Modulation by Wnt/β-catenin signaling, Stem Cells Dev., 19(9):1307-19, 2010.
  31. Kehoe, D.E., Jing, D., Lock, L.T., Tzanakakis, E.S., Scalable Stirred-suspension Bioreactor Culture of Human Pluripotent Stem Cells, Tissue Eng. Part A, 16(2):405-21, 2010.
  32. Lock, L.T., Tzanakakis, E.S., Expansion and differentiation of human embryonic stem cells to endoderm progeny in a microcarrier stirred-suspension culture, Tissue Eng. Part A, 15(8):2051-63, 2009.
  33. Jing, D., Parikh, A., Canty, J.M., Tzanakakis, E.S., Stem cells for heart cell therapies, Tissue Eng. Part B, 14(4):393-406, 2008.
  34. Kehoe, D.E., Lock. L.T., Parikh, A., Tzanakakis, E.S., Propagation of embryonic stem cells in stirred suspension without serum, Biotechnol. Prog., 24(6):1342-52, 2008.
  35. Chemler*, J., Lock*, L.T., Koffas, M.A.G., Tzanakakis, E.S., Standardized Biosynthesis of Flavan-3-ols with Effects on Pancreatic Beta-Cell Insulin Secretion, Appl. Microbiol. Biotechnol., 77(4):797-807, 2007.*These authors have contributed equally.
  36. Lock, L.T., Tzanakakis, E.S., Stem/progenitor cell sources of insulin-producing cells for the treatment of diabetes, Tissue Eng., 13(7):1399-1412, 2007.
  37. Kawahira, H., Ma, N.H., Tzanakakis, E.S., McMahon, A.P., Chuang, P.T., Hebrok, M., “Combined Activities of Hedgehog Signaling Inhibitors Regulate Pancreas Development“, Development,130(20):4871-79, 2003.
  38. Tzanakakis, E.S., Waxman, D.J., Hansen, L.K., Remmel, R.P., Hu, W.S., Long-term Enhancement of CYP2B1/2 Expression in Rat Hepatocyte Spheroids through Adenovirus-mediated Gene Transfer, Cell Biol. Toxicol., 18:13-27, 2002.
  39. Tzanakakis, E.S., Hsiao, C.C., Matsushita, T., Remmel, R.P., Hu, W.S., Probing Enhanced Cytochrome P450 2B1/2 Activity in Rat Hepatocyte Spheroids through Confocal Laser Scanning Microscopy, Cell Transplant., 10(3):329-342, 2001.
  40. Tzanakakis, E.S., Hansen, L.K., Hu, W.S., The Role of Actin Filaments and Microtubules in Hepatocyte Spheroid Self-Assembly, Cell Motil. Cytoskeleton, 48(3):175-189, 2001.
  41. Tzanakakis, E.S., Hess, D.J., Sielaff, T.D., Hu, W.S., Extracorporeal Tissue Engineered Liver-Assist Devices, Annu. Rev. Biomed. Engr., 2:607-632, 2000.

Books edited

  • Stem Cells – From Mechanisms to Technologies, Editors: Stachowiak, M.K. and Tzanakakis, E.S., World Scientific Publishing, 2011.

Book chapters

  • “Bioreactors and the Design of the Stem Cell Niche”, Fan, Y., Jing, D., Tzanakakis, E.S., in the volume in Stem Cell Niche – Stem Cells and Regenerative Medicine series, edited by K. Turksen, Springer, 2015.
  • “Stem Cell Bioprocessing for Regenerative Medicine”, Jing, D., Parikh, A. and Tzanakakis E.S., in Stem Cells – From Mechanisms to Technologies, edited by Stachowiak, M.K. and Tzanakakis, E.S., World Scientific Publishing, 2011.
  • “A Common Integrative Nuclear Signaling Module for Stem Cell Development”, Stachowiak, M.K., Stachowiak, E.K., Aletta, J.M. and Tzanakakis E.S., in Stem Cells – From Mechanisms to Technologies, edited by Stachowiak, M.K. and Tzanakakis, E.S., World Scientific Publishing, 2011.
  • “Advances in Adult Stem Cell Culture,” Tzanakakis, E.S. and Verfaillie, C.M., in Cell Culture Technology for Pharmaceutical and Cell-based Therapies, edited by Ozturk, S. and Hu, W.S., CRC Press, 693-722, August 2005.

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