Plasma miRNA Biomarkers in Mitral Valve Disease in Canines

Sponsor: Private Foundation

IACUC protocol#: G2015-58                                                                                                                                 Status:  Currently enrolling

Description:

The goal of this study is to compare plasma biomarkers in the form of extracellular RNA in dogs with mitral valve disease presenting with versus without congestive heart failure.

This study will be an important step towards making exosome analysis a useful and readily available tool for evaluating the progression, the molecular basis for remodeling, and development of specific therapies for mitral valve disease.

Inclusion/exclusion criteria:

All dogs should be over eight years of age in order to control for age related differences.

Healthy: for controls the dogs will be defined as a healthy animal with a normal physical exam, normal CBC/chemistry panel/UA and no evidence of a heart murmur as documented by a veterinarian

There will be four populations that will be included in this study:

  • Group 1: Healthy dogs with no cardiac disease
  • Group 2: Dogs with mitral valve disease not in congestive heart failure.
  • Group 3: Dogs with mitral valve disease in congestive heart failure.

Contact Information:

For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at:  clinicaltrials@tufts.edu