Clinical trials for the Anesthesia specialty

  • CSRC Protocol # 110-16

    Status: Currently enrolling


    Our overall goal is to measure the incidence of vomiting, gastroesophageal reflux (GER) and regurgitation in dogs after pre-anesthetic administration of acepromazine and dexmedetomdine . These complications can potentially result in severe esophageal damage and aspiration of stomach contents causing pneumonia .

    This study will allow us to identify the most efficient drug regime that reduces the incidence of GER and regurgitation during anesthesia in particular in those patients more predisposed to gastrointestinal complications. The study will also allow us to institute early treatment with antiemetics and gastrointestinal protectants once GER is detected. It is also our aim to raise awareness in regards to these potential complications.

    Inclusion Criteria:

    Healthy dogs that are scheduled to undergo an elective soft tissue or orthopedic procedure that are:

    • 6 months to 8 years of age
    • Male or female
    • weighing 5 kg (11 lb) to 35 kg (77 lb)

    Exclusion Criteria:

    • Dogs will be excluded from this study if they have vomited or regurgitated within a week of the scheduled elective soft tissue or orthopedic procedure .
    • Dogs will also be excluded if the randomized treatment does not provide enough sedation to place an intravenous catheter in a safe and ethical manner.

    Client Benefits:

    Participation in the study will allow us to identify peri-operative regurgitation and reflux earlier than if your pet was not included in this study. If there is evidence of regurgitation during the procedure, your animal will be promptly treated (suction and/or esophageal wash). This study will also provide data of the occurrence of perioperative reflux which would not be otherwise identified. The information will be considered in the postoperative management of your pet. Your pet's participation will also  allow us to gain information which will help in the management of other dogs in the future that undergo general anesthesia

    Contact information:

    For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at: