Clinical trials for Cardiology specialty

  • Sponsor: Private Foundation

    IACUC protocol#: G2015-58                                                                                                                                 Status:  Currently enrolling


    The goal of this study is to compare plasma biomarkers in the form of extracellular RNA in dogs with mitral valve disease presenting with versus without congestive heart failure.

    This study will be an important step towards making exosome analysis a useful and readily available tool for evaluating the progression, the molecular basis for remodeling, and development of specific therapies for mitral valve disease.

    Inclusion/exclusion criteria:

    All dogs should be over eight years of age in order to control for age related differences.

    Healthy: for controls the dogs will be defined as a healthy animal with a normal physical exam, normal CBC/chemistry panel/UA and no evidence of a heart murmur as documented by a veterinarian

    There will be four populations that will be included in this study:

    • Group 1: Healthy dogs with no cardiac disease
    • Group 2: Dogs with mitral valve disease not in congestive heart failure.
    • Group 3: Dogs with mitral valve disease in congestive heart failure.

    Contact Information:

    For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at:


  • CSRC Protocol # 004.17

    Status:  Currently enrolling


    Vitamin D has long been known to play an important role in regulating bone and calcium metabolism. However, vitamin D also is associated with other body systems and disease conditions. There is growing recognition of associations between vitamin D status and cardiovascular diseases in people, including hypertension and heart disease leading to heart failure.  Vitamin D has been shown to have several cardioprotective effects.  In people with cardiovascular disease, vitamin D deficiency is associated with disease progression and poor prognosis.

    Recently, two studies in dogs with heart failure have identified lower vitamin D concentrations compared to healthy controls, and it appears that this may be associated with worse outcomes . It is not known whether cats with heart disease have low levels of vitamin D compared to normal cats, and if so, whether an association exists between vitamin D status and disease severity . Cardiomyopathies are common heart diseases in cats, affecting 10-15% of all cats.

    Inclusion Criteria:

    Cats with dilated, hypertrophic, restrictive, or unclassified cardiomyopathies of any stage of severity and with no other major disease conditions

    Client benefits:

    The study covers the cost of 4 blood tests (packed cell volume, total solids, Azo-Stix, and glucose). Blood for these tests will be analyzed immediately so that information can be used to assist in the care of the individual cat. In addition, your cat's participation will allow us to gain information which will help in the diagnosis and treatment of other cats with heart disease. You understand that your cat's participation in this study may not alleviate or cure his/her condition.

    Contact information:

    For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at: