ACVECC Seminal Articles

This list contains articles 3-10 years old from core journals and articles within the last 10 years from non-core journals and is designed to bridge a perceived gap in the recommended reading between recent journal articles, non-core journals and textbooks. It contains article the committee deems likely to inform and impact the practice of veterinary ECC. We aim to keep this list to <100 articles and will review and update it annually.


1. Braun A, Chang D, Mahadevappa K, et al. Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill. Crit Care Med. 2011; 39(4): 671-677. article pdf

2. Holowaychuk MK, Hansen BD, DeFrancesco TC, Marks SL. Ionized hypocalcemia in critically ill dogs. J Vet Intern Med. 2009; 23(3): 509-513. article pdf

3. Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011; 364(26): 2483-2495. article pdf

4. Valverde A, Hatcher ME, Stampfli HR. Effects of fluid therapy on total protein and its influence on calculated unmeasured anions in the anesthetized dog. J Vet Emerg Crit Care 2008; 18(5): 480-487. article pdf

5. Wehausen CE, Kirby R, Rudloff E. Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008). J Am Vet Med Assoc. 2011; 238(7): 909-914. article pdf


6. Aarnes TK, Bednarski RM, Lerche P, et al. Effect of intravenous administration of lactated Ringer’s solution or hetastarch for the treatment of isoflurane-induced hypotension in dogs. Am J Vet Res.  2009; 70(11): 1345-1353. article pdf


7. Biomarkers in Veterinary Cardiology. J Vet Cardiol. 2009; 11(S1): S1-S98. link to issue

8. Tag TL, Day TK. Electrocardiographic assessment of hyperkalemia in dogs and cats. J Vet Emerg Crit Care. 2008; 18(1): 61-67. article pdf


9. Kakkar AK, Cimminiello C, Goldhaber SZ, et al. Low-molecular-weight heparin and mortality in acutely ill medical patients. N Engl J Med. 2011; 365(26): 2463-2472. article pdf

10. Marik PE, Corwin HL. Acute lung injury following blood transfusion: Expanding the definition. Crit Care Med. 2008; 36(11): 3080-3084. article pdf

11. McDevitt RI, Ruaux CG, Baltzer WI. Influence of transfusion technique on survival of autologous red blood cells in the dog. J Vet Emerg Crit Care. 2011; 21(3): 209-216. article pdf

12. Napolitano LM, Kurek S, Luchette FA, et al. Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med. 2009; 37(12): 3124-3157. article pdf

13. Patterson J, Rousseau A, Kessler RJ, Giger U. In vitro lysis and acute transfusion reactions with hemolysis caused by inappropriate storage of canine red blood cell products. J Vet Intern Med. 2011; 25(4): 927-933. article pdf

14. Smith SA, McMichael MA, Gilor S, Galligan AJ, Hoh CM. Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples. Am J Vet Res. 2012; 73(6):789–98. article pdf


15. Zeugswetter F, Handl S, Iben C, Schwendenwein I. Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats. J Feline Med Surg. 2010; 12(4): 300-5. article pdf


16. Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF. Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006; 21(5): 255-277. article pdf

17. Connally HE, Thrall MA, Hamar DW. Safety and efficacy of high-dose fomepizole compared with ethanol as therapy for ethylene glycol intoxication in cats. J Vet Emerg Crit Care. 2010; 20(2): 191-206. article pdf

18. American Academy of Clinical Toxicology Position Statements

19. Peterson ME, Matz M, Seibold K, et al. A randomized multicenter trial of Crotalidae polyvalent immune F(ab) antivenom for the treatment of rattlesnake envenomation in dogs. J Vet Emerg Crit Care. 2011; 21(4): 335-345. article pdf


20. de Smet AMGA, Kluytmans JAJW, Cooper BS, et al. Decontamination of the digestive tract and oropharynx in ICU patients. New Engl J Med. 2009; 360(1): 20-31. article pdf


21. Hayes GM, Mathews K, Floras A, Dewey C. Refractometric total plasma protein measurement as a cage-side indicator of hypoalbuminemia and hypoproteinemia in hospitalized dogs. J Vet Emerg Crit Care. 2011; 21(4): 356-362. article pdf


22. Bazick HS, Chang D, Mahadevappa K, et al. Red cell distribution width and all-cause mortality in critically ill patients. Crit Care Med. 2011; 39(8): 1913-1921. article pdf

23. Lanaux TM, Rozanski EA, Simoni RS, et al. Interpretation of canine and feline blood smears by emergency room personnel. Vet Clin Pathol. 2011; 40(1): 18-23. article pdf

24. O’Marra SK, Delaforcade AM, Shaw SP. Treatment and predictors of outcome in dogs with immune-mediated thrombocytopenia. J Am Vet Med Assoc. 2011; 238(3): 346-352. article pdf

25. Sorenmo KU, Harwood LP, King LG, Drobatz KJ. Case-control study to evaluate risk factors for the development of sepsis (neutropenia and fever) in dogs receiving chemotherapy. J Am Vet Med Assoc. 2010; 236(6):650-6. article pdf


26. Latenser BA. Critical care of the burn patient: The first 48 hours. Crit Care Med. 2009; 37(10): 2819-2826. article pdf


27. None


28. Brauer C, Jambroszyk M, Tipold A. Metabolic and toxic causes of canine seizure disorders: A retrospective study of 96 cases. Vet J. 2011; 187(2): 272-275. article pdf

29. Cooper DJ, Rosenfeld JV, Murray L, et al. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011; 364(16): 1493-1502. article pdf

30. Zimmermann R, Hulsmeyer VI, Sauter-Louis C, Fischer A. Status epilepticus and epileptic seizures in dogs. J Vet Intern Med. 2009; 23(5): 970-976. article pdf


31. Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011; 365(6): 506-517. article pdf

32. Heyland DK, Cahill N, Day AG. Optimal amount of calories for critically ill patients: depends on how you slice the cake! Crit Care Med. 2011; 39(12): 2619-2626. article pdf

33. Kutsogiannis J, Alberda C, Gramlich L, et al. Early use of supplemental parenteral nutrition in critically ill patients: results of an international multicenter observational study. Crit Care Med. 2011; 39(12): 2691-2699. article pdf

34. Ray CC, Callahan-Clark J, Beckel NF, Walters PC. The prevalence and significance of hyperglycemia in hospitalized cats. J Vet Emerg Crit Care. 2009; 19(4): 347-351. article pdf

35. Rice TW, Mogan S, Hays MA, et al. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med. 2011; 39(5): 967-974. article pdf


36. Bellomo R, Cass A, Cole L, et al. Intensity of continuous renal-replacement therapy in critically ill patients. New Engl J Med. 2009; 361(17): 1627-1638. article pdf

37. Harison E, Langston C, Palma D, Lamb K. Acute Azotemia as a Predictor of Mortality in Dogs and Cats. J Vet Intern Med. 2012; 26(5): 1093–8. article pdf

38. Maddens B, Heiene R, Smets P, et al. Evaluation of kidney injury in dogs with pyometra based on proteinuria, renal histomorphology, and urinary biomarkers. J Vet Intern Med. 2011; 25(5): 1075-1083. article pdf

39. Segev G, Livne H, Ranen E, Lavy E. Urethral obstruction in cats: predisposing factors, clinical, clinicopathological characteristics and prognosis. J Feline Med Surg. 2011; 13(2): 101-108. article pdf

40. Whittemore JC, Marcum BA, Mawby DI, et al. Associations among albuminuria, C-reactive protein concentrations, survival predictor index scores, and survival in 78 critically ill dogs. J Vet Intern Med. 2011; 25(4): 818-824. article pdf


41. Pretzer SD. Medical management of canine and feline dystocia. Theriogenology. 2008; 70(3): 332-336. article pdf

42. Traas AM. Resuscitation of canine and feline neonates. Theriogenology. 2008; 70(3): 343-348. article pdf

43. Traas AM. Surgical management of canine and feline dystocia. Theriogenology. 2008; 70(3): 337-342. article pdf


44. Foronda FK, Troster EJ, Farias JA, et al. The impact of daily evaluation and spontaneous breathing test on the duration of pediatric mechanical ventilation: a randomized controlled trial. Crit Care Med. 2011; 39(11): 2526-2533. article pdf

45. Pang D, Caulkett JHNA, Duke T. Partial pressure of end-tidal C02 sampled via an intranasal catheter as a substitute for partial pressure of arterial C02 in dogs. J Vet Emerg Crit Care. 2007; 17(2): 143-148. article pdf

46. Papazian L, Forel JM, Gacouin A et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010; 363(12): 1107-16. article pdf

47. Swinbourne F, Baines EA, Baines SJ, Halfacree ZJ. Computed tomographic findings in canine pyothorax and correlation with findings at exploratory thoracotomy. J Small Anim Pract. 2011; 52(4): 203-208. article pdf

48. Villar J, Blanco J, Anon JM, et al. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med. 2011; 37(12): 1932-1941. article pdf


49. Annane D, Vignon P, Renault A, Bollaert PE, Charpentier C, Martin C, et al. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet. 2007; 370(9588): 676-684. article pdf

50. DeClue AE, Osterbur K, Bigio A, Sharp CR. Evaluation of serum NT-pCNP as a diagnostic and prognostic biomarker for sepsis in dogs. J Vet Intern Med. 2011; 25(3): 453-459. article pdf

51. Duffy AL, Butler AL, Radecki SV, Campbell VL. Comparison of continuous arterial pressure waveform analysis with the lithium dilution technique to monitor cardiac output in conscious dogs with systemic inflammatory response syndrome. Am J Vet Res. 2009; 70(11): 1365-1373. article pdf

52. Marshall JC, Reinhart K, Forum IS. Biomarkers of sepsis. Crit Care Med. 2009; 37(7): 2290-2298. article pdf

53. Monnet X, Jabot J, Maizel J, et al. Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patients. Crit Care Med. 2011; 39(4): 689-694. article pdf

54. Oostdijk EA, de Smet AM, Kesecioglu J, Bonten MJ. The role of intestinal colonization with gram-negative bacteria as a source for intensive care unit-acquired bacteremia. Crit Care Med. 2011; 39(5): 961-966. article pdf

55. Rahman NM, Maskell NA, West A, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011; 365(6): 518-526. article pdf

56. Rubulotta F, Marshall JC, Ramsay G, Nelson D, Levy M, Williams M. Predisposition, insult/infection, response, and organ dysfunction: A new model for staging severe sepsis. Crit Care Med.  2009; 37(4): 1329-1335. article pdf

57. Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. New Engl J Med. 2008; 358(9): 877-887. article pdf

58. Zahar JR, Timsit JF, Garrouste-Orgeas M, et al. Outcomes in severe sepsis and patients with septic shock: pathogen species and infection sites are not associated with mortality. Crit Care Med. 2011; 39(8): 1886-1895. article pdf


59. Antonelli M, Levy M, Andrews PJ, Chastre J, Hudson LD, Manthous C, Meduri GU, Moreno RP, Putensen C, Stewart T, Torres A. Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006. Intensive Care Med. 2007; 33(4): 575-590. article pdf

60. Chohan AS, Greene SA, Grubb TL, et al. Effects of 6% hetastarch (600/0.75) or lactated Ringer’s solution on hemostatic variables and clinical bleeding in healthy dogs anesthetized for orthopedic surgery. Vet Anaesth Analg. 2011; 38(2): 94-105. article pdf

61. Shih A, Giguere S, Vigani A, et al. Determination of cardiac output by ultrasound velocity dilution in normovolemia and hypovolemia in dogs. Vet Anaesth Analg. 2011; 38(4): 279-285. article pdf

62. Shih A, Maisenbacher HW, Bandt C, et al. Assessment of cardiac output measurement in dogs by transpulmonary pulse contour analysis. J Vet Emerg Crit Care. 2011; 21(4): 321-327. article pdf

63. Stiell IG, Nichol G, Leroux BG, et al. Early versus later rhythm analysis in patients with out-of-hospital cardiac arrest. N Engl J Med. 2011; 365(9): 787-797. article pdf

64. van der Wal G, Brinkman S, Bisschops LL, et al. Influence of mild therapeutic hypothermia after cardiac arrest on hospital mortality. Crit Care Med. 2011; 39(1): 84-88. article pdf

65. Vigani A, Shih AC, Buckley GJ, et al. Cardiopulmonary effects of a new inspiratory impedance threshold device in acute hemorrhagic shock in dogs. J Vet Emerg Crit Care. 2011; 21(6): 618-624. article pdf

66. Special Issue: Reassessment Campaign on Veterinary Resuscitation: Evidence and Knowledge Gap Analysis on Veterinary CPR. J Vet Emerg Crit Care. 2012; S4-131. link to issue

This list is based on the 2016 reading list. This page was last updated March 2016.