Publications

Shuyi Ma, Suraj Jaipalli, Jonah Larkins-Ford, Jenny Lohmiller, Bree B. Aldridge, David R. Sherman, Sriram Chandrasekaran.  Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis. mBio. Nov 2019, 10 (6) e02627-19 link

Manu De Rycker, David Horn, Bree Aldridge, et al., Setting Our Sights on Infectious Diseases. ACS Infectious Diseases. 2019. link

Smith TC,  Aldridge BB. Targeting drugs for tuberculosis. 28
June 2019. Science. Vol. 364, Issue 6447, pp. 1234. free full text

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, et al. Definitions and guidelines for research on antibiotic persistence. Nat. Rev. Microbiol. 2019. link

Katzir, I., Cokol, M., Aldridge, B.B.*, Alon, U.* “Prediction of ultra-high-order antibiotic combinations based on pairwise interactions.” (2019) PLoS Computational Biology 15(1):e1006774. link

Boot, M., Commandeur, S., Subudhi, A.K., Bahira, M., Smith II, T.C., Abdallah, A.M., van Gemert, M., Lelièvre, J., Ballell, L., Aldridge, B.B, Pain, A., Speer, A., and Bitter, W. “Accelerating early anti-tuberculosis drug discovery by creating mycobacterial indicator strains that predict mode of action.” Antimicrobial Agents and Chemotherapy (in press). link

Logsdon, M.M. and Aldridge, B.B. “Stable Regulation of Cell Cycle Events in Mycobacteria: Insights from Inherently Heterogeneous Bacterial Populations.” (2018) Frontiers in Microbiology, 9:514. link

Hayashi, J.M., Richardson, K., Melzer, E.S., Sandler, S.J., Aldridge, B.B., Siegrist, M.S., Morita, Y.S. (2018). “Stress-Induced Reorganization of the Mycobacterial Membrane Domain.” mBio, 9(1). link

Sundarakrishnan, A., Chen, Y., Black, L. D., Aldridge, B. B. , Kaplan, D.L. (2018). “Engineered cell and tissue models of pulmonary fibrosis” Advanced Drug Delivery Reviews, in press. link

Mann, K. M., Huang, D. L., Hooppaw, A. J., Logsdon, M. M., Richardson, K., Lee, H. J., Kimmey, J. M., Aldridge, B. B. , Stallings, C. (2017). “Rv0004 is a new essential member of the mycobacterial DNA replication machinery” PLoS Genetics, 13(11), e1007115. link

Srinivasan Vijay, Dao N. Vinh, Hoang T. Hai, Vu T. N. Ha, Vu T. M. Dung, Tran D. Dinh, Hoang N. Nhung, Trinh T. B. Tram, Bree B. Aldridge, Nguyen T. Hanh, Do D. A. Thu, Nguyen H. Phu, Guy E. Thwaites, Nguyen T. T. Thuong. “Influence of Stress and Antibiotic Resistance on Cell-Length Distribution in Mycobacterium tuberculosis Clinical Isolates” Frontiers in Microbiology. 21 November 2017. link

Logsdon, M., Ho, P., Papavinasasundaram, K., Richardson, K., Cokol, M., Sassetti, C., Amir, A., Aldridge, B.B. “A parallel adder coordinates mycobacterial cell cycle progression and cell size homeostasis in the context of asymmetric growth and organization” Current Biology. 6 November 2017; 27:1-8. link

Cokol, M., Kuru, N., Bicak, E., Larkins-Ford, J., Aldridge, B.B. “Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis” Science Advances. 2017 October 11: E1701881. link

Richardson, K., Bennion, O.T., Tan, S., Hoang, A.N., Cokol, M., Aldridge, B.B. “Temporal and intrinsic factors of rifampicin tolerance in mycobacteria” Proc Natl Acad Sci U S A. 2016 June 29. link

Hayashi, J.M., Luo, C.Y., Mayfield, J.A., Hsu T., Fukuda, T., Walfield, A.L., Giffen, S.R., Leszyk, J.D., Baer, C.E., Bennion, O.T., Madduri, A., Shaffer, S.A., Aldridge, B.B., Sassetti, C.M., Sandler, S.J., Kinoshita, T., Moody, D.B., Morita, Y.S. “Spatially distinct and metabolically active membrane domain in mycobacteria.” Proc Natl Acad Sci U S A. 2016 May 10;113(19):5400-5. link

Aldridge B.B., Keren I., Fortune S.M. “The Spectrum of Drug Susceptibility in Mycobacteria. “Microbiol Spectr. 2014 Oct;2(5). link

Aldridge B.B., Rhee K.Y. “Microbial metabolomics: innovation, application, insight.” Curr Opin Microbiol. 2014 Jun;19:90-6. link

Chao, M.C., Kieser, K.J., Minami, S, Mavrici, D., Aldridge, B.B., Fortune, S.M., Alber, T., Rubin, E.J. “Protein Complexes and Proteolytic Activation of the Cell Wall Hydrolase RipA Regulate Septal Resolution in Mycobacteria.” PLoS Pathogens, 2013, 9(2): e1003197. link

Wirth, S.E., Krywy, J.A., Aldridge, B.B., Fortune, S.M., Fernandez-Suarez, M., Gray, T.A., Derbyshire, K.M., “Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.” Molecular Microbiology, 2012, 83(3):654-664. PMCID: PMC3277861 link

Aldridge, B.B., Fernandez-Suarez, M., Heller, D., Ambravaneswaran, V., Irimia, D., Toner, M., Fortune, S.M., “Asymmetry and aging in mycobacterial cells lead to variable growth and antibiotic susceptibility.” Science, 2012, 335 (6064): 100-104. PMCID: PMC3397429 link

Aldridge, B.B., Gaudet, S., Lauffenburger, D.A., Sorger, P.K., “Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.” Molecular Systems Biology, 2011, 7:553. PMCID: PMC3261706 link

Aldridge, B.B., Saez-Rodriguez, J., Muhlich, J., Sorger, P.K., Lauffenburger, D.A., “Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/Insulin-induced signaling.” PLoS Computational Biology, 2009, 5(4): e1000340. PMCID: PMC2663056 link

Albeck, J.G., Burke, J.M., Aldridge, B.B., Zhang, M.S., Lauffenburger, D.A., Sorger, P.K. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.” Mol. Cell, 2008, 30(1):11-25. PMCID: PMC2858979 link

Aldridge, B.B., Burke, J., Lauffenburger, D., Sorger, P. Physicochemical Modelling of Cell Signaling Pathways. Nature Cell Biol, 2006, 8:1195-2003. link

Aldridge, B.B., Haller, G., Sorger, P., and Lauffenburger, D. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst. Biol, 2006. 153 (6). link

Draviam VM, Shapiro I, Aldridge B., and Sorger PK. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 2006. 25 (12): 2814-27. PMCID: PMC1500857 link

 

 

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