The Clark Research Group develops new materials and analytical methods to identify, quantify, and understand the function of RNA modifications in biological systems.

Our long term goals are to advance sample preparation, chromatographic separation, and mass spectrometry approaches to facilitate the characterization of nucleic acid modifications in the central nervous system, single cells, and subcellular structures.

We leverage neurobiological models and combine techniques in analytical chemistry, molecular biology, and neuroscience to investigate mechanisms of post-transcriptional regulation.