Methylated DNA immunoprecipitation sequencing (MeDIP-Seq) is an experimental method used to identify the methylated sequences throughout the genome.

In a 2014 paper by Yanchang Wei et al , researchers induced pre-diabetes in mice and compared their methylomes with those of their offspring with MeDIP-Seq. Inherited Risk of Diabetes in Mice summarizes their experiments.

Epigenetic reprogramming removes methylation marks during gametogenesis and embryogenesis. As summarized in PGC7: Protection Against Demethylation during Gametogenesis, a 2012 paper by Toshinobu Nakamura et al elucidates a molecular mechanism in which a maternal factor protects some methylation marks from reprogramming, allowing epigenetic inheritance.