DNA METHYLATION PATTERNS IN FATHERS WITH PTSD AND THEIR OFFSPRING
DNA Demethylation Mechanism
When AID/APOBEC creates a thymine:guanine mismatch, the base excision repair mechanism corrects this issue. This process is shown in Figure 21.
Figure 20: This mechanism highlights the reaction performed by AID/APOBEC, which deaminates 5mC, creating thymine, which will be excised by the BER machinery. Figure 21: The BER mechanism, in which T glycosylase removes thymine from the strand, AP lyase cleaves the DNA backbone, AP endonuclease cleaves the remaining 3′ sugar group, and then repair and ligation enzymes reinsert the correctly matching cytosine base (20).
2 Replies to “DNA Demethylation Mechanism”
Add a detailed, step-by-step description of demethylation like that included in the previous mechanism page, with mentions of the enzymes involved if possible.
Add a detailed, step-by-step description of demethylation like that included in the previous mechanism page, with mentions of the enzymes involved if possible.
Most reviews/papers only give information on the pathway, rather than the mechanisms. If I find an adequate one, I will add it!