Clinical Study Opportunity: Vitamin D Status in Cats with Primary Hepatobiliary Disease


The liver performs an essential role in the absorption of dietary vitamin D and synthesis of the active form of vitamin D. Vitamin D deficiency is a known problem in people with liver disease and these patients routinely receive supplementation. Vitamin D deficiency has not been documented in cats with liver disease. Our goal is to determine if cats with primary liver disease have low levels of vitamin D. If they do, this finding could lead to the development of clinical guidelines for vitamin D supplementation.

Inclusion Criteria:

Cats over one year of age with one of the following:

  • Hyperbilirubinemia
  • Elevated ALT and/or ALP
  • Cytologic or histopathologic diagnosis of a primary hepatobiliary disease

Exclusion Criteria:

  • Hyperthyroidism
  • Acute pancreatitis
  • IRIS Stage 2 chronic kidney disease (creatinine >1.6 mg/dl)
  • Congestive heart failure
  • Hypercalcemia (elevated ionized calcium)
  • Corticosteroid or ursodeoxycholic acid administration within the last two weeks

Client Benefits:

The study will cover the cost of the vitamin D panel. Your cat’s participation will also allow us to gain information that will help in the treatment of other cats with this condition

Contact information:

For questions regarding the clinical trial, please email the clinical trials technician, Diane Welsh at