COVID-19 and the policies designed to counter it in American prisons pose distinct medical, emotional, psychological, and economic threats for incarcerated women and their families. Drawing on analysis of 138 women’s state and federal prisons across the United States, coupled with review of research on women’s prisons, and detailed profiles of the hardest hit facilities with insights from the women incarcerated inside them, this paper provides unique insight on the impacts of COVID-19 behind bars.