Featured Research

Our research focuses on complex diseases that affect the skin, brain and other organs including autoimmunity and cancer. We are interested in understanding how autoimmunity occurs, including triggers and immunopathogenesis, and what we can do to stop it through development of treatment options. We are also interested in understanding how to tweak the adaptive immune system to recognize cancers for immunotherapy. We use several different models to study pathology, with an emphasis on immune cell migration and function, and cross-talk between the immune system and the target tissue. Our current focus is studying spontaneous disease processes in pets as large animal models of human disease. Our goal is to identify biomarkers and treatment targets for both veterinary and human medicine.

Disease areas we are currently investigating with selected publications & published abstracts:

Cutaneous T Cell Lymphoma

Cathepsin W, T-cell receptor-associated transmembrane adapter 1, lymphotactin and killer cell lectin like receptor K1 are sensitive and specific RNA biomarkers of canine epitheliotropic lymphoma

Spatial Transcriptomics and Proteomics of Mycosis Fungoides Biopsies from Skin of Color Patients Reveal Biomarkers and Potential Treatment Targets

Interleukin-16 as a marker of Sézary syndrome onset and stage

Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences

Cutaneous Lupus Erythematosus

A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases

Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus-Like Inflammation

Shared inflammatory and skin-specific gene signatures reveal common drivers of discoid lupus erythematosus in canines, humans and mice

Using Gene Expression Analysis to Understand Complex Autoimmune Skin Disease Patients: A Series of Four Canine Cutaneous Lupus Erythematosus Cases

Morphea (Localized Scleroderma)

Jak Inhibition Prevents Bleomycin-Induced Fibrosis in Mice and Is Effective in Patients with Morphea

CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts

Multiple Sclerosis

Targeted proteomics of cerebrospinal fluid in treatment naïve multiple sclerosis patients identifies immune biomarkers of clinical phenotypes

Targeted Cerebrospinal Fluid Proteomics as a Tool for Analyzing Immunophenotype Heterogeneity in Multiple Sclerosis (page 14)

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Full list of our publications:

https://pubmed.ncbi.nlm.nih.gov/?term=jillian+richmond

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Special thanks to the organizations who fund our research: