This clinical trial is being conducted across the following institutions:

1. Tufts Medical Center (Eastern Massachusetts); Principal Investigator: Chenchen Wang, MD, MSc
Tufts Medical Center offers world-class research and clinical care, with expertise in managing chronic conditions like knee OA.

2. Boston Medical Center (Eastern Massachusetts); Principal Investigator: Eric Roseen, DC, PhD
As a leading safety-net hospital, Boston Medical Center serves diverse communities and is committed to innovative, patient-centered care.

3. UCLA Health (Southern California); Principal Investigator: Helen Lavretsky, MD, MS
UCLA Health is renowned for advancing healthcare research, offering state-of-the-art treatments, and promoting patient well-being.

4. Cleveland Clinic Ohio and Florida (Northeast Ohio & Southern Florida); Principal Investigator: Robert Saper, MD, MPH
With locations in Ohio and Florida, Cleveland Clinic provides comprehensive healthcare services and is a leader in clinical trials for chronic conditions.

Clinical Coordinating Center (Tufts Medical Center)

Lead: Chenchen Wang, Project Manager: Sherwood Alexis

The Clinical Coordinating Center is responsible for the development and maintenance of TAICHIKNEE’s operations.

Data Coordinating Center (Tufts Medical Center)

Lead: Ludovic Trinquart, Team: Michelle Lee-Bravati, Ben Koethe, Cortney Wieber

The Data Coordinating Center is responsible for managing TAICHIKNEE’s data and monitoring the study’s activities.