The Question:
Heart disease refers to a heterogenous range of illnesses involving irregularities in the cardiovascular system, with the most common being coronary artery disease1. This ailment causes decreased blood flow to the heart, often caused by clogged arteries, and can lead to a myocardial infarction or heart attack. Recovery can span multiple months and is often a challenging and prolonged process, partially due to the fact that cardiomyocytes, the muscle cells of the heart, exit the cell cycle and cease to divide following an early period of development. The serious burden of cardiovascular disease (CVD), impacting 38 million people worldwide and amounting an estimated economic cost of $70 billion, warrants the need for increased diagnostic and therapeutic research2 (Figure 1).

While current therapies are limited, new fields are emerging regarding the use of biotechnologies as a treatment for heart failure. We therefore set out to investigate two key questions:
- How does knowledge of cardiovascular mechanisms and development spark innovation in terms of heart failure therapeutics?
- What biomaterials and regenerative heart therapies exist as viable options?
December 7, 2023 at 8:33 pm
I really like figure 1, it is a really helpful and approachable graphic for visualizing the information that you are talking about. One suggestion would be to move it up so that it is located right after the paragraph where you first mention it. I personally think that encountering the figure right after it is mentioned would help the flow of reading (readers won’t have to skip around).
In your figure you mention CVD multiple times without a clear explanation as to what it stands for. I would consider a quick mention of what CVD is either in your figure caption or in the text above the figure in order to make it extra clear to the reader.
The box stating “heart disease statistics 2023” also feels a little repetitive because it is identical to the first part of the figure caption. Maybe a variation in the caption and the inclusion of a little more context/detail could be an approach to solving this. (One way you could do this is by mentioning CVD and what it stands for in your caption)
December 7, 2023 at 11:16 pm
Super clear introduction! I like how cardiovascular illnesses are introduced, their significance discussed, and with a clean transition to your question. Also, very much appreciate the infographic, it helps further understand the significance of the topic. Few things I noticed on my end is that for question 1, the ‘spark innovation’ is slightly ambiguous and maybe could be defined a little more, especially since question 2 is very well defined. As a reader, what can I expect to be the outcome of your exploration of cardiovascular mechanisms? Furthermore, for the infographic, the citation link leads me to the citation page but I can’t seem to find a specific citation for the AHA. Maybe including a number citation in the figure caption would make it easier to read more about the data?
December 8, 2023 at 2:06 pm
I really liked how multifaceted your question was! The discussion of cardiovascular mechanisms and heart failure therapeutics lends itself to biochemistry with a drug delivery/development type of angle. In contrast, the mention of biomaterials and regenerative heart therapies brings to mind a more material science/medical device engineer type perspective. It definitely makes me interested what therapies you choose to explore!
I also found Fig 1, though quite serious, a bit funny. Specifically because I consistently sleep significantly more or less that 7-8 hours a night. I can’t imagine how much extra CVD risk I’ve added to my life! This may be a sign to get my sleep schedule back to normal. There is one critique I have of the figure—the red text is a bit hard to read against the purple background. I think if you used a more pastel red or a more contrasting shade of purple or would make the graphic a bit more discernible.
December 8, 2023 at 5:54 pm
One specific edit that should be made is the typo in figure 1, where you write “1h” but then “7-8 hr”. They should be consistent so one easy fix if to change 1h to 1 hr.
Generally, I love that your project expands beyond an isolated biomedical analysis, but seeks to explore the nature of development within the field of research itself and the evolution of our understanding of CVD. This is super important for continual innovation and expansion of knowledge, which is great!
December 8, 2023 at 5:56 pm
Additionally, I think it would be helpful to simply define hypertension and its relationship to the heart in figure 1, for the general audience that may not be familiar with the concept and may prefer a definition early on rather than in later pages.
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