Inhibiting the p53-MDM2 protein-protein interaction

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Molecular graphics were generated using VMD [28] and PyMOL [29].

All figures reproduced from previously published works were used in accordance with the original publishers’ rights and permissions policies, and written permission to do so was obtained when these policies required it.

3 Comments

  1. Suraj Shah

    A note for references: I mentioned this in the question page, but I think it is a little distracting to have references at the bottom of each webpage. If your goal is to make it accessible, you can still include all the references on this last webpage and then hyperlink each citation to the source link or the references tab.

    On the whole, this is an extremely detailed project and I learned so much! I was truly fascinated about the applications of D-peptides. My biggest suggestion would be to make each section a little more user-friendly and readable. There are lots of details discussed in each section and simple figures diagramming pathways or modes of action/inhibition would significantly help ease the presentation of this information. It is clear that you did phenomenal research into the topic, and I think restructuring how it is presented on the webpage will help readability of the project.

  2. Katherine E. Macarthur

    This project was amazing! It was such a pleasure to read. I agree with Suraj that having all of your references on one page and just linking to them would be so much easier for the reader.

    Going off of Suraj’s comments, having more figures to summarize the information and more summary points would be good. There is so much detail here, but I sometimes wasn’t able to appreciate it because I was so bogged down by the details. Having figures or summaries to allow readers to take a step back and remember what the big picture is would add so much.

    Overall, though, well done!

  3. lbrown04

    I’m going to digress a little from Suraj here. I think that the references on the bottom of the pages are actually useful. If I were trying to do research based off of the information on this website, I wouldn’t want to constantly be flipping to the reference page everytime I wanted to read more on the source. Have the citations repeated at the bottom of the page would mean I wouldn’t have to do that. Plus, I don’t think it’s that distracting.

    As for my other general comments, as I’ve mentioned several times in my comments the description is very detailed and excellent, but hard to read. I don’t think it would be the worst thing in the world for you to edit some of the nuggets of information in order to increase the flow of the page. Additionally, figures help a lot.

    Overall, this is a really good project, and I can clearly tell that not only have you done a lot of great research, but you’ve learned a ton about the topic along the way. Keep up the great work!

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