Publication – Xu Lab @ Tufts Biomedical Engineering

Bibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/qiaobing.xu.1/bibliography/46202659/public/?sort=date&direction=descending

Drug Delivery

Khirallah, J.; Xu, Q.* A high-throughput approach of screening nanoparticles for targeted delivery of mRNA. Cell Reports Methods, 2023, 3 (8), in press.
Zhao, Y.; Ye, Z.; Song, D.; Wich, D.; Gao, S.; Khirallah, J.; Xu, Q.* Nanomechanical action opens endo-lysosomal compartments. Nature Comm. 2023, 14, Article number: 6645.
Ye, Z.; Harmon, J.; Ni, W.; Li, Y.; Wich, D.; Xu, Q.* The mRNA Vaccine Revolution: COVID-19 has launched the future of Vaccinology. ACS Nano, 2023, 17 (16), 15231-15253.(invited review)
Ely, Z. A.; Mathey-Andrews, N.; Naranjo, S.; Gould, S.; Mercer, K. L.; Newby, G. A.; Cabana, C. M.; Rideout, W. M.; Jaramillo, G. C.; Khirallah, J. M.; Holland, K.; Randolph, P. B.; Freed-Pastor, W. A.; Davis, J. R.; Kulstad, Z.; Westcott, P. M.K.; Lin, L.; Anzalone, A. V.; Horton, B. L.; Pattada, N. B.; Shanahan, S. L.; Ye, Z.; Spranger, S.; Xu, Q.; Sánchez-Rivera, F. J.; Liu, D. R.; Jacks, T. A prime editor mouse for modeling a broad spectrum of somatic mutations in vivo. Nature Biotech. 2023, May 11. doi: 10.1038/s41587-023-01783-y.
Zhao, Y.; Wich, D.; Xu, Q.* Gemini Amphiphiles: Robust Cytosolic Delivery of Therapeutic Biomacromolecules through Non-Endocytic Translocation Pathways. ACS Cent. Sci. 2023, https://doi.org/10.1021/acscentsci.3c00793 (invited views)
Zhao, Y.; Gao, S.; Song, D.; Ye, Z.; Xu, R.; Luo, Y.; Xu, Q.* Lipidoid Artificial Compartments for Bidirectional Regulation of Enzyme Activity through Nanomechanical Action. J. Am. Chem. Soc. 2023, 145, 1, 551–559. (inside cover)
Khirallah, J.; Eimbinder, M.; Li, Y.; Xu, Q.* The Clinical Progress of genome editing technology and their in vivo delivery techniques. Trends in Genetics, 2023 Mar;39(3):208-216. (Invited review)
Carter, B.; Huang, P.; Liu, G.; Liang, Y.; Lin, P. J. C.; Peng, B. H.; McKay, L. G. A.; Dimitrakakis, A.; Hsu, J.; Tat, V.; Saenkham-Huntsinger, P.; Chen, J. J.; Kaseke, C.; Gaiha, G. D.; Xu, Q.; Griffiths, A.; Tam, Y. K.; Tseng, C. K.; Gifford, D. K. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta. Front. Immunol. 2023,14:1135815.
Chen, J.; Ye, Z.; Huang, C.; Qiu, M.; Song, D.; Li, Y.; Xu, Q.* Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response. Proc. Natl. Acad. Sci., 2022, 119 (34) e2207841119.
Song, D.; Xu, Q.* Engineering a Nano/Biointerface for Cell and Organ-Selective Drug Delivery. Langmuir 2022, 38 (30), 9092-9098. (Perspective)
Xiao, Q.; Zoulikha, M.; Qiu, M.; Teng, C.; Lin, C.; Li, X.; Sallam, M. A.; Xu, Q.*; He, W.* The effects of protein corona on in vivo fate of nanocarriers. Advanced Drug Delivery Reviews 2022, 114356
Qiu, M.; Tang, Y.*; Chen, J.; Muriph, R.; Ye, Z.; Huang, C.; Evans, J.; Henske, E. P.*; Xu, Q.* Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. Proc. Natl. Acad. Sci., 2022, 119(8):e2116271119.
Li, Y.; Ye, Z.; Yang, H.; Xu, Q.* Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs. Acta Pharm Sin. B, 2022, 12, 2624-2639.
Wu, J.; Shaoo, J. K.; Li, Y.; Xu, Q.*; Kaplan, D. L. Challenges in delivering therapeutic peptides and proteins: A silk-based solution. J. Controlled Release 2022, 345, 176-189.
Chen, J.; Chen, J. Z.; Xu, Q.* Current Developments and Challenges of mRNA Vaccines. Annu. Rev. Biomed. Eng. 2022, Vol. 24, 85-109.
Hershman, R. L.; Li, Y.; Ma, F.; Xu, Q.; Van Deventer, J. A. Intracellular Delivery of Antibodies for Selective Cell Signaling Interference. ChemMedChem, 2022, 17 (6), e202100678
Ye, Z.; Chen, J.; Zhao, X.; Li, Y.; Harmon, J.; Huang, C.; Chen, J.; Xu, Q.* In Vitro Engineering Chimeric Antigen Receptor Macrophages and T Cells by Lipid Nanoparticle-Mediated mRNA Delivery. ACS Biomater. Sci. Eng. 2022, 8(2):722-733.
Qiu, M.; Li, Y.; Bloomer, H.; Xu, Q.* Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing. 2021, Accounts of Chemical Research 54(21):4001-4011.
Yang T, Han H, Chen Y, Yang L, Parker R, Li Y, Kaplan DL*, Xu Q.* Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model. Bioactive Materials 2021 6(11):3671-3677.
Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J; SCGE Consortium. The NIH Somatic Cell Genome Editing program. Nature. 2021, 592, 195-204.
Ho TC, Kim HS, Chen Y, Li Y, LaMere MW, Chen C, Wang H, Gong J, Palumbo CD, Ashton JM, Kim HW, Xu Q, Becker MW, Leong KW. Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy. Sci Adv. 2021 7, eabg3217.
Chen, J.; Qiu, M.; Ye, Z.; Nyalile, T.; Li, Y.; Glass, Z.; Zhao, X.; Yang, L.; Chen, J. Z.; Xu, Q.* In situ cancer vaccination using lipidoid nanoparticles. Sci. Adv. 2021, 7, eabf1244.
Qiu, M.; Glass, Z.; Chen, J.; Haas, M.; Jin, X.; Zhao, X.; Rui, X.; Ye, Z.; Li, Y.; Zhang, F.; Xu, Q.* Lipid nanoparticle-mediated co-delivery of Cas9 mRNA and single guide RNA achieves liver-specific in vivo genome editing of Angptl3. Proc. Natl. Acad. Sci., 2021, 118, e2020401118.
Zhao, X.; Glass, Z.; Chen, J.; Yang, L.; Kaplan, D. L.; Xu, Q.* mRNA Delivery Using Bioreducible Lipidoid Nanoparticles Facilitates Neural Differentiation of Human Mesenchymal Stem Cells. Adv. Healthc. Mater. 2021, 10, 2000938.
Chen, J.; Qiu, M.; Ma, F.; Yang, L.; Glass, Z.; Xu, Q.* Enhanced Protein Degradation by Intracellular Delivery of Pre-Fused PROTACs Using Lipid-like Nanoparticles. J. Control. Release 2021, 330, 1244-1249.
Zhao X, Chen J, Qiu M, Li Y, Glass Z, Xu Q.* Imidazole-based synthetic lipidoids for in vivo mRNA delivery into primary T lymphocytes. Angew Chem. Int. Ed. 2020, 59, 20083-20089.
Li, Y.; Li, P.; Li, R.; Xu, Q.* Intracellular Antibody Delivery Mediated by Lipids, Polymers, and Inorganic Nanomaterials for Therapeutic Applications. Advanced Therapeutics, 2020, 3, 2000178.
Li, Y.; Li, R.; Chakraborty, A.; Ogurlu, R.; Zhao, X.; Chen, J.; Xu, Q.* Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery. Bioconjugate Chemistry, 2020, 31, 1835−1843.
Li, Y., Jarvis, R.; Zhu, K.; Glass, R.; Ogurlu, R.; Gao, P.; Li, P.; Chen, J.; Yu, Y.; Yang, Y.; Xu, Q.* Protein and mRNA Delivery Enabled by Cholesteryl Based Biodegradable Lipidoid Nanoparticles, Angewandte Chemie International Edition, 2020, 59, 14957-14964
Ma, F.; Yang, ; Sun, Z.; Chen, J.; Rui, X.; Glass, Z.; Xu, Q.* Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Science Advances, 2020, 6, eabb4429.
Yang, X.; Chang, J.; Jiang, Y.; Xu, Q.; Wang, M.; Mao, L. Q. In Vivo Activation of Pro-Protein Therapeutics via Chemically Engineered Enzyme Cascade Reaction. CCS Chem. 2020, 2, 780–790.
Yang, L.; Ma, F.; Liu, F.; Chen, J.; Zhao, X.; Xu, Q.* Efficient delivery of antisense oligonucleotides using bioreducible lipid nanoparticles in vitro and in vivo. Molecular Therapy Nucleic Acids, 2020, 19, 1357-1367.
Liu, F.; Yang, L.; Li, Y.; Junier, A.; Ma, F.; Chen J.; Han, H.; Glass, Z.; Zhao, X.; Kumamoto, C.; Sang, H.; Xu, Q.* In vitro and in vivo study of an Amphotericin B formulation with quaternized bioreducible lipidoids. ACS Biomaterial Science and Engineering. 2020, 6, 2, 1064-1073
Li, Y.; Glass, Z.; Huang, M.; Chen, Z. Y.; Xu, Q.* Ex Vivo Cell-Based CRISPR/Cas9 Genome Editing for Therapeutic Applications Biomaterials. Biomaterials, 2020, Mar;234:119711.
Parker, R.; Wu, W.; McKay, T.; Xu, Q.; Kaplan, D. Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties. Journal of Functional Biomaterials, 2019, 10(4), 49.
Qiu, M.; Glass, Z.; Xu, Q.* Nonviral Nanoparticles for CRISPR-Based Genome Editing: Is It Just a Simple Adaption of What Have Been Developed for Nucleic Acid Delivery? Biomacromolecules, 2019, 20, 3333-3339. (Virtual Issue: Biomacromolecules for Emerging Biological and Medical Science and Technology to celebrate Biomacromolecules 20th Anniversary)
Liu, J.; Chang, J.; Jiang, Y.; Meng, X.; Sun, T.; Mao, L.; Xu, Q.*; Wang, M.* Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles. Adv. Mater. 2019, 31, 1902575
Tang, Q.; Wang, J.; Jiang, Y.; Zhang, M.; Chang, J.; Xu, Q.; Mao, L.; Wang, M.* Developing Chemically Modified Redox-responsive Protein As Smart Therapeutics, Chemical Communication, 2019, 55, 5163–5166.
Li, Y.; Chakaborty, Anirban, Chen, J.; Xu, Q.* Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery. ACS Biomaterial Science and Engineering, 2019, 5, 2391-2398.
Ma, X.; Zhou, P.; Kugelmass, A.; Toskic, D.; Warner, M.; Lee, L.; Fogaren, T.; Godara, A.; Wang, M.; Li, Y.; Yang, L.; Xu, Q., Comenzo, R. L.* A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases, Gene Therapy, 2019, 26, 187–197.
Chang, J; Chen, X.; Glass, Z.; Gao, F.; Mao, L.; Wang, M*; Xu, Q.* Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing, Account of Chemical Research, 2019, 52 (3), pp 665–675.
Ghazanfari, S.; Alberti, KA; Xu, Q.; Khademhossini, A.* Evaluation of an elastic decellularized tendon-derived scaffold for the vascular tissue engineering application. Journal of Biomedical Materials Research Part A, 2019, in press.
Brega, V.; Scaletti, F.; Zhang, X.; Wang, L.; Li, P.; Xu, Q.; Rotello, V.; Thomas, S.* Polymer Amphiphiles for Photoregulated Anticancer Drug Delivery, 2019, ACS Appl. Mater. Inter., 113, 2814-2820.
Li Y, Bolinger J, Yu Y, Glass Z, Shi N, Yang L, Wang M, Xu Q.* Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles., Biomaterial Science 2019, 7, 596 – 606.
Li Y, Li AC, Xu Q.* Intracellular Delivery of His-Tagged Genome-Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles. Adv Healthc Mater. 2018 Nov 22:e1800996.
Bahmani B., Uehara M., Jiang L., Ordikhani F., Banouni N., Ichimura T., Solhjou Z., Furtmüller G.J., Brandacher G., Alvarez D., von Andrian, U.H., Uchimura K., Xu, Q., Vohra I., Yilmam OA., Haik Y., Azzi J., Kasinath V., Bromberg J., McGrath, M., Abdi R. Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. Clinical Investigation 2018, 128(11):4770-4786.
Li, Y.; Glass, Z.; Xu, Q.* Rescued from the fate of neurological disorder, Nature Biomedical Engineering, 2018, 2, 469–470.(invited News & Views)
Sui L, Wang M, Han Q, Yu L, Zhang L, Zheng L, Lian J, Zhang J, Valverde P, Xu Q, Tu Q, Chen J. A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. 2018 Sep;177:88-97.
Li Y, Yang T, Yu Y, Shi N, Yang L, Glass Z, Bolinger J, Finkel IJ, Li W, Xu Q.* Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. 2018 Sep;178:652-662.
Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. International Journal of Cancer 2018 143, 1797-1805.
Chang ZM, Wang Z, Shao D, Yue J, Xing H, Li L, Ge M, Li M, Yan H, Hu H, Xu Q, Dong WF*. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10656-10663.
Glass, Z.; Lee, M. Li, Y.; Xu, Q. Engineering the Delivery System for CRISPR-based Genome Editing, Trends in Biotech. 2018, 36 (2), 173–185. PMID: 29305085.
Gao, X.; Tao, Y.; Lamas V.; Huang, M.; Yeh, W-H; Pan, B.; Hu, Y-J; Hu, J. H.; Thompson, Shu, Y.; Y. Li.; Wang, H.; Yang, S.; Xu, Q.; D.; Polley, D. B.; Lieberman, M. C.; Kong, W-J.; Holt, J. R., Chen, Z. Y.; Liu, D. R. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature 2018, 553, 217–221.
Sui L, Wang M, Han Q, Yu L, Zhang L, Zheng L, Lian J, Zhang J, Valverde P, Xu Q, Tu Q, Chen J. A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. Biomaterials 2018,177:88-97.
Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. Int J Cancer. 2018 doi: 10.1002/ijc.31559.
Li Y, Yang T, Yu Y, Shi N, Yang L, Glass Z, Bolinger J, Finkel IJ, Li W, Xu Q.* Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Biomaterials 2018 Mar 8. pii: S0142-9612(18)30170-4.
Chang ZM, Wang Z, Shao D, Yue J, Xing H, Li L, Ge M, Li M, Yan H, Hu H, Xu Q, Dong WF. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10656-10663. doi: 10.1021/acsami.7b19325.
Glass, Z.; Li, Y.; Xu, Q.* Nanoparticles for CRISPR–Cas9 delivery, Nature Biomedical Engineering. 2017, 1, 854-855.
Tang, R.; Wang, M.; Ray, M.; Jiang, Y.; Jiang, Z.; Xu, Q.*; Rotello, V. M.* “Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags” J. Am. Chem. Soc. 2017, 139 (25), pp 8547–8551.
Wang, X.; Li, Y.; Li, Q.; Neufeld, C.; Pouli, D.; Sun, S.; Yang, L.; Deng, P.; Wang, M.; Georgakoudi, I.; Tang, S.; Xu, Q.* “Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles.” Journal of Controlled Release, 2017, 263:39-45.
Wang, M.; Glass, Z.; Xu, Q.* Non-viral Delivery of Genome-editing Nucleases for Gene Therapy. Gene Therapy, 2017, 24, 144–150.
Wang Z, Shao D, Chang Z, Lu M, Wang Y, Yue J, Yang D, Li M, Xu Q, Dong WF. Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma. ACS Nano. 2017 Dec 26;11(12):12732-12741.
Zhou N, Cao X, Du X, Wang H, Wang M, Liu S, Nguyen K, Schmidt-Rohr K, Xu Q, Liang G, Xu B. “Hyper-Crosslinkers Lead to Temperature- and pH-Responsive Polymeric Nanogels with Unusual Volume Change.” Angew Chem Int Ed Engl. 2017, 56, 2623–2627.
Xu, Q.*; Neufeld, C. I. “Pulling Cancer Cells Apart with a Net of Nanofibers.”, Chem, 2017, 2, 167–168.
Altınoǧlu, S., Wang, M., Li, K., Li, Y., Xu, Q.* “Intracellular delivery of PTEN protein using cationic lipidoids for cancer therapy”, Biomaterial Sciences, 2016, 4, 1773 – 1780.
Wang, M.; Zuris, J. A.; Meng, F.T.; Rees, H.; Deng, P.; Gao, X.; Pouli, D.; Wu, Q.; Georgakoudi, I.; Liu, D. R.*; Xu, Q.* “Efficient Genome Editing Protein Delivery using Bioreducible Lipid-like Materials”, Proceedings of the National Academy of Sciences, 2016, 113, 2868-2873.
Hu, X., Feeney, M. J., McIntosh, E., Mullahoo, J., Jia, F., Xu, Q., Thomas, S. W. Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes. ACS Appl. Mater. Interfaces,2016, 8 (36), 23517–23522
Kern A, Zhou CW, Jia F, Xu Q, Hu LT. Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release. Vaccine. 2016; 34(38):4507-13.
Wang, M.; Altinoglu, S.; Takeda, Y. S. Xu, Q.* “Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery”, 2015, PLoS One, 10(11): e0141860.
Altınoǧlu, S.; Wang, M.; Xu, Q.* “Combinatorial Library Strategies for Synthesis of Cationic Lipid-like Nanoparticles and Their Potential Medical Applications”, Nanomedicine, 2015, 10(4): 643-57.
Wang, M.; Sun, S.; Neufeld, C.; Perez-Ramirez, B.; Xu, Q.* “Reactive Oxygen Species (ROS)-Responsive Protein Modification and its Intracellular Delivery”, Angewandte Chemie International Edition, 2014, 53, 13444-13448.
Wang, M.; Alberti, K. A.; Sun, S.; Xu, Q.* “Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy”, Angewandte Chemie International Edition, 2014, 53(11):2893-8.
Wang, M.; Alberti, K. A.; Varone, A.; Pouli D.; Georgakoudi, I.; Xu, Q.* “Enhanced Intracellular siRNA Delivery Using Bioreducible Lipid-like Nanoparticles”, Advanced Healthcare Materials, 2014, 3, 1398-1403.
Sun S.; Wang, M.; Alberti, K. A.; Choy, A.; Xu, Q.* “DOPE Facilitates Quaternized Lipidoids (QLDs) for in vitro DNA Delivery”, Nanomedicine: NBM, 2013, 9, 849-854.
Wang, M.; Sun S.; Alberti, K. A.; Xu, Q.* “A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery”, ACS Synthetic Biology, 2012, 1, 403–407.
Sun, S.; Wang, M.; Knupp, S. A.; Soto-Feliciano, Y.; Hu, X.; Kaplan, D. L.; Anderson, D. G.; Langer, R.; Xu, Q.* “Combinatorial library of lipidoids for In vitro DNA delivery, Bioconjugate Chemistry, 2012, 23, 135–140.
Sant, S.; Tao, S.; Fisher, O.; Xu, Q.; Peppas, N. A.; Khademhosseini, A. “Microfabrication technologies for oral drug delivery”, Advanced Drug Delivery Reviews, 2012, 64, 496–507.

Biomaterials and Tissue Engineering:

Yang, T.; Li, Y.; Hong, Y.; Chi, L.; Liu, C.; Lan, Y.; Wang, Q.; Yu, Y.; Xu, Q.; Teng, W. The construction of biomimetic cementum through a combination of bioskiving and fluorine-containing biomineralization. Frontiers in Bioengineering and Biotechnology, 2020, 8: 341.
Ko E, Alberti K, Lee JS, Yang K, Jin Y, Shin J, Yang HS, Xu Q,* Cho SW.* Nanostructured Tendon-Derived Scaffolds for Enhanced Bone Regeneration by Human Adipose-Derived Stem Cells. ACS Appl. Mater. Interfaces. 2016; 8(35):22819-29.
Mostafalu P., Akbari M., Alberti K. A., Xu, Q., Khademhosseini A. Sonkusale S. R. A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics. Microsystems & Nanoengineering. 2016, 2, Article number: 16039.
Jiang Y, Wang M, Hardie J, Tonga GY, Ray M, Xu Q, Rotello VM.,Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring. Small 2016; 12(28):3775-9.
Alberti KA, Neufeld CI, Wang J, & Xu Q * In Vivo Peripheral Nerve Repair Using Tendon-derived Nerve Guidance Conduits. ACS Biomaterials Science and Engineering, 2016, 2, 937–945.
Domigan, L. J.; Andersson, M.; Alberti, K. A.; Chesler, M.; Xu, Q. Johansson, J.; Rising, A.; Kaplan, D. L.”Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands”, Insect Biochem Mol Biol. 2015, 65,100-106.
Jabbari, E. *; Leijten, J.; Xu, Q. *; Khademhosseini, A.* “The matrix reloaded: the evolution of regenerative hydrogels”, Materials Today, 2015, Nov.
Alberti, K. A.; Xu, Q.* “Biocompatibility and degradation of tendon-derived scaffolds”, Regenerative Biomaterials, 2015, 112015, 1–11.
Takeda, Y. S.; Xu, Q.* “Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Neural Progenitor Cells”, PLoS One, 2015, 10, e0135111.
Takeda, Y. S.; Xu, Q.* “Synthetic and Nature-derived Lipid Nanoparticles for Neural Regeneration”, Nerve Regeneration Research, 2015, 10(5):689-90.
Alberti, A.; Sun, J. Y.; Illeperuma, W. R.; Suo, Z.; Xu, Q.* “Laminar Tendon Composites with Enhanced Mechanical Properties”, Journal of Material Science, 2015, 50: 2616-25.
Solhjou, Z.; Athar, H.; Xu, Q.; Abdi, R. “Emerging Therapies Targeting Intra-organ Inflammation in Transplantation”, American Journal of Transplantation, 2015, 15(2):305-11.
Alberti, K. A.; Hopkins, A.; Tang-Schomer, M.; Kaplan, D. L.; Xu, Q.* “The Behavior of Neuronal Cells on Tendon-Derived Collagen Sheets as Potential Substrates for Nerve Regeneration”, 2014, 35, 3551-3557.
Xia, X. X.; Wang, M.; Lin, Y.; Xu, Q.; Kaplan, D. L. “Hydrophobic drug-triggered self-assembly of nanoparticles form silk-elastin-like protein polymers for drug delivery.” Biomacromolecules, 2014, 15, 908-914.
Kuang, Y.; Shi, J.; Li, J.; Yuan, D.; Alberti, K.; Xu, Q.; Xu, B. “Pericellular Hydrogel/Nanonets Inhibit Cancer Cells”, Angewandte Chemie International Edition, 2014, 53, 8104-8107.
Takeda, Y.; Xu, Q.* “Fabrication of 2D and 3D constructs from reconstituted decellularized tissue extracellular matrices”, Journal of Biomedical Nanotechnology, 2014, 10, 3631-3637.
Wang, Q.; Xia, X.; Huang, W.; Lin, Y.; Xu, Q.; Kaplan, D. L. “High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials”, Advanced Functional Materials, 2014, 24, 4303-4310.
Lin, Y.; Xia, X.; Wang, M.; Wang, Q.; An, B.; Hu, T.; Xu, Q.; Omenetto, F.; Kaplan, D. “Genetically Programmable Thermoresponsive Plasmonic Gold/Silk-Elastin Protein Core/Shell Nanoparticles”, Langmuir, 2014, 30, 4406-4414.
Ameri, S. K.; Singh, P. K.; Dokmeci, M. R.; Khademhosseini, A.; Xu, Q.; Sonkusale, S. R. “All Electronic Approach for High-throughput Cell Trapping and Lysis with Electrical Impedance Monitoring,” Biosensors and Bioelectronics, 2014, 54, 462-467.
Alberti, K. A.; Xu, Q.* “Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections”, Advanced Healthcare Materials, 2013, 2, 817–821.
Dai, X.; Knupp, S.; Xu, Q.*, “Patterning Nanoparticles in 3D Matrix using Electric-Field Assisted Gel Transferring (EFAGT)”, Langmuir, 2012, 28, 2960-2964.
Dai, X.; Schalek, R.; Xu, Q.* “Staining-and-Etching: a simple method to fabricate inorganic nanostructures from tissue slices”, Advanced Materials, 2012, 24, 370-374.
Xia, X.; Xu, Q.; Hu, X.; Qin, G.; Kaplan, D. L. “Tunable Self-Assembly of Genetically Engineered Silk-Elastin Protein Polymers”, Biomacromolecules, 2011, 12 , 3844–3850.
Dai, X.; Xu, Q.* “Nanostructured substrate fabricated by sectioning tendon using a microtome for tissue engineering”, Nanotechnology, 2011, 22, 494008.

Before joining Tufts University:

Huo, B.; Lu, X.L.; Costa K.D.; Xu, Q.; Guo, X. E. “An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation.” Cell Calcium, 2010, 47, 234-241.
Cheng, H.; Kastrup, C.J.; Ramanathan, R.; Siegwart, D.J.; Ma, M.L.; Bogatyrev, S.R.; Xu, Q.; Whitehead, K. A.; Langer, R.; Anderson, D.G. “Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery.”, ACS Nano, 2010, 4, 625-631.
Dang, T. T.; Xu, Q.; Bratlie, K. M.; Chen, I.; Langer, R.; Anderson, D. G. “Fabrication of Cell-laden Hydrogel Microcapsules Using Thermo-molded Polypropylene Mesh.” Biomaterials, 2009, 30, 6896-6902.
Cho, S. W.; Goldberg, M.; Son, S. M.; Xu, Q.; Yang, F.; Mei, Y.; Bogatyrev, S.; Langer, R.; Anderson, D. G. “Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells.” Advanced Functional Materials, 2009, 19, 112-3118.
Xu, Q.; Hahsimoto, M.; Dang, T. T.; Hoare, T.; Kohane, D. S.; Whitesides, G. M.; Langer, R.; Anderson, D. G. “Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-focusing Device for Controlled Drug Delivery.” Small, 2009, 5, 1575-1581.
Mei, Y.; Cannizzaro, C.; Park, H. S.; Xu, Q.; Bogatyrev, S. R.; Yi, K.; Goldman, N.; Langer, R.; Anderson, D. G. “Cell-compatible, Multicomponent Protein Arrays with Subcellular Feature Resolutions.” Small, 2008, 4, 1600-1604.
Cho, S. W.; Hartle, L.; Son, S. M.; Yang, F.; Goldberg, M.; Xu, Q.; Langer, R.; Anderson, D. G. “Delivery of Small Interfering RNA for Inhibition of Endothelial Cell Apoptosis by Hypoxia and Serum Deprivation.” Biochemical and Biophysical Research Communications, 2008, 376, 158-163.
Huo, B.; Lu, X. L.; Hung, C. T.; Costa, K. D.; Xu, Q.; Whitesides, G. M.; Guo, X. E. “Fluid Flow Induced Calcium Response in Bone Cell Network.” Cellular and Molecular Bioengineering, 2008, 1, 58-66. (Featured on the cover page)
Xia, N.; Thodeti, C. K.; Hunt, T. P.; Xu, Q.; Ho, M.; Whitesides, G. M.; Westervelt, R.; Ingber, D. E. “Directional Control of Cell Motility through Focal Adhesion Positioning and Spatial Control of Rac Activation.” The FASEB Journal, 2008, 22, 1649-1659.
Xu, Q.; Rioux, R. M.; Dickey, M. D.; Whitesides G. M. “Nanoskiving: A New Method to Produce Arrays of Nanostructures.” Accounts of Chemical Research, 2008, 46, 1566-1577. (Invited review)
Xu, Q.; Rioux, R. M.; Whitesides G. M. “Fabrication of Complex Metallic Nanostructures by Nanoskiving.” ACS Nano, 2007, 1, 215-227.
Xu, Q.; Bao, J.; Rioux, R. M.; Castillejos R. P.; Capasso, F.; Whitesides, G. M. “Fabrication of large-area patterned nanostructures for optical applications by nanoskiving.” Nano Letters, 2007, 7, 2800-2805. (Featured in Photonics.com 10/01/2007)
Lahav, M.; Weiss, E. A.; Xu, Q.; Whitesides, G. M. “Core-Shell and Segmented Polymer-Metal Composite Nanostructures.” Nano Letters, 2006, 6, 2166-2171.
Guo, X. E.; Takai, E.; Jiang, X. J.; Xu, Q.; Whitesides, G. M.; Costa, K. D.; Yardley, J. T.; Hung, C. T.; Chow E. M., Hantschel T, Costa K. D. “Intracellular calcium waves in bone cell networks under single cell nanoindentation.” Molecular Cellular Biomechanics, 2006, 3, 95-107.
Xu, Q.; Castillejos R. P.; Li, Z.; Whitesides, G. M. “Fabrication of High Aspect Ratio Metallic Nanostructures by Nanoskiving.” Nano Letters, 2006, 6, 2163-2165.
Xu, Q.; Bao, J.; Capasso, F.; Whitesides, G. M. “Surface Plasmon Resonance in Gold Nanowires Fabricated by Nanoskiving.” Angewandte Chemie International Edition, 2006, 45, 3631-3635.
Jiang, X.; Xu, Q.; Dertinger, S. K. W.; Stroock, A. D.; Fu, T-M.; Whitesides, G. M. “A General Method for Patterning Gradients of Biomolecules on Surfaces Using Microfluidic Network.” Analytical Chemistry, 2005, 77, 2338-2347.
Xu, Q.; Mayers, B. T.; Lahav, M.; Vezenov, D. V.; Whitesides, G. M. “Approaching Zero: Using Crystal Fracture as a Metric for Replica Molding.” Journal of the American Chemical Society, 2005, 127, 854-855.
Cao, T.; Xu, Q.; Winkleman, A.; Whitesides, G. M. “Fabrication of Thin, Metallic Films along the Sidewalls of a Topographically Patterned Stamp and Their Applications in Charge Printing.” Small, 2005, 1, 1191-1195.
Gates, B. D.; Xu, Q.; Steward M.; Ryan, D.; Wilson, C. G.; Whitesides, G. M. “New Approaches to Nanofabrication: Molding, Printing, and Other Techniques.” Chemical Reviews, 2005, 105, 1171-1196.
Xu, Q.; Gates, B. D.; Whitesides, G. M. “Fabrication of Metal Structures with Nanometer-Scale Lateral Dimensions by Sectioning Using a Microtome.” Journal of the American Chemical Society, 2004, 126, 1332-1333.
Xu, Q.; Tonks, I.; Fuerstman, M. J.; Love J. C.; Whitesides, G. M. “Fabrication of Free-standing Metallic Pyramidal Shells.” Nano Letters, 2004, 4, 2509-2511.
Gates, B. D.; Xu, Q.; Thalladi, V. R.; Cao, T.; Knickerbocker, T.; Whitesides, G. M. “Shear Patterning of Microdominos: A New Class of Procedures for Making Micro- and Nanostructures.” Angewandte Chemie International Edition, 2004, 43, 2779-2783.
Gates, B. D.; Xu, Q.; Love, J. C.; Wolfe, D. B.; Whitesides, G. M. “Unconventional Nanofabrication.” Annual Review of Materials Research, 2004, 34, 339–372.
Cui, S. X.; Zhang, W.; Xu, Q.; Wang, C.; Zhang, X. “Supramolecular Research by Single Molecule Force Spectroscopy.” Macromolecular Symposium, 2003, 195, 109-114.
Xu, Q.; Zhang, W.; Zhang, X. “Oxygen Bridge Inhibits Conformational Transition of 1,4-Linked alpha-D-galactose Detected by Single-molecule Atomic Force Microscopy.” Macromolecules, 2002, 35, 871-876.
Xu, Q.; Zou, S.; Zhang, W.; Zhang, X. “Single-molecule Force Spectroscopy on Carrageenan by Means of AFM.” Macromolecular Rapid Communications, 2001, 22, 1163-1167.
Zhang, W.; Xu, Q.; Zou, S.; Li, H.; Xu, W.; Zhang, X.; Shao, Z.; Kudera, M.; Gaub, H. E. “Single molecule Force Spectroscopy on Bombyx mori Silk Fibroin by Atomic Force Microscopy.” Langmuir, 2000, 16, 4305-4308.

PROCEEDING OF CONFERENCE

Xu, Q.; Whitesides, G. M. “Nanoskiving: A Novel Method for Nanofabrication and its Applications in Nanophotonics.” Proceedings of SPIE, 2009, 7205, 72050P-1. (Invited paper)

BOOK CHAPTER

Co-editor (Xiaohu Gao, Qiaobing Xu) of Section VII “Nanomaterials for Biomedicine” in Encyclopedia of Nanomaterials (edited by Younan Xia and Yadong Yin), ELSEVIER, work in progress.
Li, Y.; Glass, Z.; Xu, Q.* “Chemical Modification of Proteins and Their Intracellular Delivery Using Lipidoid Nanoparticles”, Chapter, in Methods in Molecular Biology, Humana Press (Springer Science), 2020.
Altınoǧlu, S.; Xu, Q.* “Combinatorial Cationic Lipid Library Synthesis for Drug Delivery”, Chapter, in Perspectives in Micro and Nanotechnology for Biomedical Applications, Editors, Chan, J. et al, 2015, Publisher, Imperial College Press, UK
Sun, S.; Neufeld, C. I.; Latypov, R. F.; Perez-Ramirez, B.; Xu, Q.*, “Biophysical Methods for the Studies of Protein-Lipid/Surfactant Interactions, Chapter 17 in Recent Progress in Colloid and Surface Chemistry with Biological Applications, ACS Symposium Series, Vol. 1215,
Alberti, K. A.; Xu, Q.* “Bioinspired Fabrication of Nanostructures from Tissue Slices”, Chapter 1 in Handbook of Biomimetics and Bioinspiration, Editors, Jabbari, E. et al. 2014.

Bibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/qiaobing.xu.1/bibliography/46202659/public/?sort=date&direction=descending

Drug Delivery

Liu, F.; Yang, L.; Li, Y.; Junier, A.; Ma, F.; Chen J.; Han, H.; Glass, Z.; Zhao, X.; Kumamoto, C.; Sang, H.; Xu, Q.* In vitro and in vivo study of an Amphotericin B formulation with quaternized bioreducible lipidoids. ACS Biomaterial Science and Engineering. 2020, 6, 2, 1064-1073

Li, Y.; Glass, Z.; Huang, M.; Chen, Z. Y.; Xu, Q.* Ex Vivo Cell-Based CRISPR/Cas9 Genome Editing for Therapeutic Applications Biomaterials. Biomaterials, 2020, Mar;234:119711.

Parker, R.; Wu, W.; McKay, T.; Xu, Q.; Kaplan, D. Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties. Journal of Functional Biomaterials, 2019, 10(4), 49.

Liu, J.; Chang, J.; Jiang, Y.; Meng, X.; Sun, T.; Mao, L.; Xu, Q.*; Wang, M.* Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles. Adv. Mater. 2019, 31, 1902575

Tang, Q.; Wang, J.; Jiang, Y.; Zhang, M.; Chang, J.; Xu, Q.; Mao, L.; Wang, M.* Developing Chemically Modified Redox-responsive Protein As Smart Therapeutics, Chemical Communication, 2019, 55, 5163–5166.

Li, Y.; Chakaborty, Anirban, Chen, J.; Xu, Q.* Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery. ACS Biomaterial Science and Engineering, 2019, 5, 2391-2398.

Ma, X.; Zhou, P.; Kugelmass, A.; Toskic, D.; Warner, M.; Lee, L.; Fogaren, T.; Godara, A.; Wang, M.; Li, Y.; Yang, L.; Xu, Q., Comenzo, R. L.* A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases, Gene Therapy, 2019, 26, 187–197.

Chang, J; Chen, X.; Glass, Z.; Gao, F.; Mao, L.; Wang, M*; Xu, Q.* Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing, Account of Chemical Research, 2019, 52 (3), pp 665–675.

Ghazanfari, S.; Alberti, KA; Xu, Q.; Khademhossini, A.* Evaluation of an elastic decellularized tendon-derived scaffold for the vascular tissue engineering application. Journal of Biomedical Materials Research Part A, 2019, in press.

Brega, V.; Scaletti, F.; Zhang, X.; Wang, L.; Li, P.; Xu, Q.; Rotello, V.; Thomas, S.* Polymer Amphiphiles for Photoregulated Anticancer Drug Delivery, 2019, ACS Appl. Mater. Inter., 113, 2814-2820.

Li Y, Bolinger J, Yu Y, Glass Z, Shi N, Yang L, Wang M, Xu Q.* Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles., Biomaterial Science 2019, 7, 596 – 606.

Li Y, Li AC, Xu Q.* Intracellular Delivery of His-Tagged Genome-Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles. Adv Healthc Mater. 2018 Nov 22:e1800996.

Li, Y.; Glass, Z.; Xu, Q.* Rescued from the fate of neurological disorder, Nature Biomedical Engineering, 2018, 2, 469–470.(invited News & Views)

Sui L, Wang M, Han Q, Yu L, Zhang L, Zheng L, Lian J, Zhang J, Valverde P, Xu Q, Tu Q, Chen J. A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. 2018 Sep;177:88-97.

Li Y, Yang T, Yu Y, Shi N, Yang L, Glass Z, Bolinger J, Finkel IJ, Li W, Xu Q.* Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. 2018 Sep;178:652-662.

Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. International Journal of Cancer 2018 143, 1797-1805.

Chang ZM, Wang Z, Shao D, Yue J, Xing H, Li L, Ge M, Li M, Yan H, Hu H, Xu Q, Dong WF*. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10656-10663.

Glass, Z.; Lee, M. Li, Y.; Xu, Q. Engineering the Delivery System for CRISPR-based Genome Editing, Trends in Biotech. 2018, 36 (2), 173–185. PMID: 29305085.

Sui L, Wang M, Han Q, Yu L, Zhang L, Zheng L, Lian J, Zhang J, Valverde P, Xu Q, Tu Q, Chen J. A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. Biomaterials 2018,177:88-97.

Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. Int J Cancer. 2018 doi: 10.1002/ijc.31559.

Li Y, Yang T, Yu Y, Shi N, Yang L, Glass Z, Bolinger J, Finkel IJ, Li W, Xu Q.* Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Biomaterials 2018 Mar 8. pii: S0142-9612(18)30170-4.

Chang ZM, Wang Z, Shao D, Yue J, Xing H, Li L, Ge M, Li M, Yan H, Hu H, Xu Q, Dong WF. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10656-10663. doi: 10.1021/acsami.7b19325.

Glass, Z.; Li, Y.; Xu, Q.* Nanoparticles for CRISPR–Cas9 delivery, Nature Biomedical Engineering. 2017, 1, 854-855.

Tang, R.; Wang, M.; Ray, M.; Jiang, Y.; Jiang, Z.; Xu, Q.*; Rotello, V. M.* “Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags” J. Am. Chem. Soc. 2017, 139 (25), pp 8547–8551.

Wang, X.; Li, Y.; Li, Q.; Neufeld, C.; Pouli, D.; Sun, S.; Yang, L.; Deng, P.; Wang, M.; Georgakoudi, I.; Tang, S.; Xu, Q.* “Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles.” Journal of Controlled Release, 2017, 263:39-45.

Wang, M.; Glass, Z.; Xu, Q.* Non-viral Delivery of Genome-editing Nucleases for Gene Therapy. Gene Therapy, 2017, 24, 144–150.

Wang Z, Shao D, Chang Z, Lu M, Wang Y, Yue J, Yang D, Li M, Xu Q, Dong WF. Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma. ACS Nano. 2017 Dec 26;11(12):12732-12741.

Zhou N, Cao X, Du X, Wang H, Wang M, Liu S, Nguyen K, Schmidt-Rohr K, Xu Q, Liang G, Xu B. “Hyper-Crosslinkers Lead to Temperature- and pH-Responsive Polymeric Nanogels with Unusual Volume Change.” Angew Chem Int Ed Engl. 2017, 56, 2623–2627.

Xu, Q.*; Neufeld, C. I. “Pulling Cancer Cells Apart with a Net of Nanofibers.”, Chem, 2017, 2, 167–168.

Altınoǧlu, S., Wang, M., Li, K., Li, Y., Xu, Q.* “Intracellular delivery of PTEN protein using cationic lipidoids for cancer therapy”, Biomaterial Sciences, 2016, 4, 1773 – 1780.

Wang, M.; Zuris, J. A.; Meng, F.T.; Rees, H.; Deng, P.; Gao, X.; Pouli, D.; Wu, Q.; Georgakoudi, I.; Liu, D. R.*; Xu, Q.* “Efficient Genome Editing Protein Delivery using Bioreducible Lipid-like Materials”, Proceedings of the National Academy of Sciences, 2016, 113, 2868-2873.

Hu, X., Feeney, M. J., McIntosh, E., Mullahoo, J., Jia, F., Xu, Q., Thomas, S. W. Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes. ACS Appl. Mater. Interfaces,2016, 8 (36), 23517–23522

Kern A, Zhou CW, Jia F, Xu Q, Hu LT. Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release. Vaccine. 2016; 34(38):4507-13.

Wang, M.; Altinoglu, S.; Takeda, Y. S. Xu, Q.* “Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery”, 2015, PLoS One, 10(11): e0141860.

Altınoǧlu, S.; Wang, M.; Xu, Q.* “Combinatorial Library Strategies for Synthesis of Cationic Lipid-like Nanoparticles and Their Potential Medical Applications”, Nanomedicine, 2015, 10(4): 643-57.

Wang, M.; Sun, S.; Neufeld, C.; Perez-Ramirez, B.; Xu, Q.* “Reactive Oxygen Species (ROS)-Responsive Protein Modification and its Intracellular Delivery”, Angewandte Chemie International Edition, 2014, 53, 13444-13448.

Wang, M.; Alberti, K. A.; Sun, S.; Xu, Q.* “Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy”, Angewandte Chemie International Edition, 2014, 53(11):2893-8.

Wang, M.; Alberti, K. A.; Varone, A.; Pouli D.; Georgakoudi, I.; Xu, Q.* “Enhanced Intracellular siRNA Delivery Using Bioreducible Lipid-like Nanoparticles”, Advanced Healthcare Materials, 2014, 3, 1398-1403.

Sun S.; Wang, M.; Alberti, K. A.; Choy, A.; Xu, Q.* “DOPE Facilitates Quaternized Lipidoids (QLDs) for in vitro DNA Delivery”, Nanomedicine: NBM, 2013, 9, 849-854.

Wang, M.; Sun S.; Alberti, K. A.; Xu, Q.* “A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery”, ACS Synthetic Biology, 2012, 1, 403–407.

Sun, S.; Wang, M.; Knupp, S. A.; Soto-Feliciano, Y.; Hu, X.; Kaplan, D. L.; Anderson, D. G.; Langer, R.; Xu, Q.* “Combinatorial library of lipidoids for In vitro DNA delivery, Bioconjugate Chemistry, 2012, 23, 135–140.

Sant, S.; Tao, S.; Fisher, O.; Xu, Q.; Peppas, N. A.; Khademhosseini, A. “Microfabrication technologies for oral drug delivery”, Advanced Drug Delivery Reviews, 2012, 64, 496–507.

Biomaterials and Tissue Engineering:

Yang, T.; Li, Y.; Hong, Y.; Chi, L.; Liu, C.; Lan, Y.; Wang, Q.; Yu, Y.; Xu, Q.; Teng, W. The construction of biomimetic cementum through a combination of bioskiving and fluorine-containing biomineralization. Frontiers in Bioengineering and Biotechnology, 2020, 8: 341.

Mostafalu P., Akbari M., Alberti K. A., Xu, Q., Khademhosseini A. Sonkusale S. R. A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics. Microsystems & Nanoengineering. 2016, 2, Article number: 16039.

Jiang Y, Wang M, Hardie J, Tonga GY, Ray M, Xu Q, Rotello VM.,Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring. Small 2016; 12(28):3775-9.

Alberti KA, Neufeld CI, Wang J, & Xu Q * In Vivo Peripheral Nerve Repair Using Tendon-derived Nerve Guidance Conduits. ACS Biomaterials Science and Engineering, 2016, 2, 937–945.

Domigan, L. J.; Andersson, M.; Alberti, K. A.; Chesler, M.; Xu, Q. Johansson, J.; Rising, A.; Kaplan, D. L.”Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands”, Insect Biochem Mol Biol. 2015, 65,100-106.

Jabbari, E. *; Leijten, J.; Xu, Q. *; Khademhosseini, A.* “The matrix reloaded: the evolution of regenerative hydrogels”, Materials Today, 2015, Nov.

Alberti, K. A.; Xu, Q.* “Biocompatibility and degradation of tendon-derived scaffolds”, Regenerative Biomaterials, 2015, 112015, 1–11.

Takeda, Y. S.; Xu, Q.* “Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Neural Progenitor Cells”, PLoS One, 2015, 10, e0135111.

Takeda, Y. S.; Xu, Q.* “Synthetic and Nature-derived Lipid Nanoparticles for Neural Regeneration”, Nerve Regeneration Research, 2015, 10(5):689-90.

Alberti, A.; Sun, J. Y.; Illeperuma, W. R.; Suo, Z.; Xu, Q.* “Laminar Tendon Composites with Enhanced Mechanical Properties”, Journal of Material Science, 2015, 50: 2616-25.

Solhjou, Z.; Athar, H.; Xu, Q.; Abdi, R. “Emerging Therapies Targeting Intra-organ Inflammation in Transplantation”, American Journal of Transplantation, 2015, 15(2):305-11.

Alberti, K. A.; Hopkins, A.; Tang-Schomer, M.; Kaplan, D. L.; Xu, Q.* “The Behavior of Neuronal Cells on Tendon-Derived Collagen Sheets as Potential Substrates for Nerve Regeneration”, 2014, 35, 3551-3557.

Xia, X. X.; Wang, M.; Lin, Y.; Xu, Q.; Kaplan, D. L. “Hydrophobic drug-triggered self-assembly of nanoparticles form silk-elastin-like protein polymers for drug delivery.” Biomacromolecules, 2014, 15, 908-914.

Kuang, Y.; Shi, J.; Li, J.; Yuan, D.; Alberti, K.; Xu, Q.; Xu, B. “Pericellular Hydrogel/Nanonets Inhibit Cancer Cells”, Angewandte Chemie International Edition, 2014, 53, 8104-8107.

Takeda, Y.; Xu, Q.* “Fabrication of 2D and 3D constructs from reconstituted decellularized tissue extracellular matrices”, Journal of Biomedical Nanotechnology, 2014, 10, 3631-3637.

Wang, Q.; Xia, X.; Huang, W.; Lin, Y.; Xu, Q.; Kaplan, D. L. “High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials”, Advanced Functional Materials, 2014, 24, 4303-4310.

Lin, Y.; Xia, X.; Wang, M.; Wang, Q.; An, B.; Hu, T.; Xu, Q.; Omenetto, F.; Kaplan, D. “Genetically Programmable Thermoresponsive Plasmonic Gold/Silk-Elastin Protein Core/Shell Nanoparticles”, Langmuir, 2014, 30, 4406-4414.

Ameri, S. K.; Singh, P. K.; Dokmeci, M. R.; Khademhosseini, A.; Xu, Q.; Sonkusale, S. R. “All Electronic Approach for High-throughput Cell Trapping and Lysis with Electrical Impedance Monitoring,” Biosensors and Bioelectronics, 2014, 54, 462-467.

Alberti, K. A.; Xu, Q.* “Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections”, Advanced Healthcare Materials, 2013, 2, 817–821.

Dai, X.; Knupp, S.; Xu, Q.*, “Patterning Nanoparticles in 3D Matrix using Electric-Field Assisted Gel Transferring (EFAGT)”, Langmuir, 2012, 28, 2960-2964.

Dai, X.; Schalek, R.; Xu, Q.* “Staining-and-Etching: a simple method to fabricate inorganic nanostructures from tissue slices”, Advanced Materials, 2012, 24, 370-374.

Xia, X.; Xu, Q.; Hu, X.; Qin, G.; Kaplan, D. L. “Tunable Self-Assembly of Genetically Engineered Silk-Elastin Protein Polymers”, Biomacromolecules, 2011, 12 , 3844–3850.

Dai, X.; Xu, Q.* “Nanostructured substrate fabricated by sectioning tendon using a microtome for tissue engineering”, Nanotechnology, 2011, 22, 494008.

Before joining Tufts University:

Huo, B.; Lu, X.L.; Costa K.D.; Xu, Q.; Guo, X. E. “An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation.” Cell Calcium, 2010, 47, 234-241.

Cheng, H.; Kastrup, C.J.; Ramanathan, R.; Siegwart, D.J.; Ma, M.L.; Bogatyrev, S.R.; Xu, Q.; Whitehead, K. A.; Langer, R.; Anderson, D.G. “Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery.”, ACS Nano, 2010, 4, 625-631.

Dang, T. T.; Xu, Q.; Bratlie, K. M.; Chen, I.; Langer, R.; Anderson, D. G. “Fabrication of Cell-laden Hydrogel Microcapsules Using Thermo-molded Polypropylene Mesh.” Biomaterials, 2009, 30, 6896-6902.

Cho, S. W.; Goldberg, M.; Son, S. M.; Xu, Q.; Yang, F.; Mei, Y.; Bogatyrev, S.; Langer, R.; Anderson, D. G. “Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells.” Advanced Functional Materials, 2009, 19, 112-3118.

Xu, Q.; Hahsimoto, M.; Dang, T. T.; Hoare, T.; Kohane, D. S.; Whitesides, G. M.; Langer, R.; Anderson, D. G. “Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-focusing Device for Controlled Drug Delivery.” Small, 2009, 5, 1575-1581.

Mei, Y.; Cannizzaro, C.; Park, H. S.; Xu, Q.; Bogatyrev, S. R.; Yi, K.; Goldman, N.; Langer, R.; Anderson, D. G. “Cell-compatible, Multicomponent Protein Arrays with Subcellular Feature Resolutions.” Small, 2008, 4, 1600-1604.

Cho, S. W.; Hartle, L.; Son, S. M.; Yang, F.; Goldberg, M.; Xu, Q.; Langer, R.; Anderson, D. G. “Delivery of Small Interfering RNA for Inhibition of Endothelial Cell Apoptosis by Hypoxia and Serum Deprivation.” Biochemical and Biophysical Research Communications, 2008, 376, 158-163.

Huo, B.; Lu, X. L.; Hung, C. T.; Costa, K. D.; Xu, Q.; Whitesides, G. M.; Guo, X. E. “Fluid Flow Induced Calcium Response in Bone Cell Network.” Cellular and Molecular Bioengineering, 2008, 1, 58-66. (Featured on the cover page)

Xia, N.; Thodeti, C. K.; Hunt, T. P.; Xu, Q.; Ho, M.; Whitesides, G. M.; Westervelt, R.; Ingber, D. E. “Directional Control of Cell Motility through Focal Adhesion Positioning and Spatial Control of Rac Activation.” The FASEB Journal, 2008, 22, 1649-1659.

Xu, Q.; Rioux, R. M.; Dickey, M. D.; Whitesides G. M. “Nanoskiving: A New Method to Produce Arrays of Nanostructures.” Accounts of Chemical Research, 2008, 46, 1566-1577. (Invited review)

Liu, J.; Chang, J.; Jiang, Y.; Meng, X.; Sun, T.; Mao, L.; Xu, Q.; Wang, M. Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles. Adv. Mater. 2019, 31, 1902575

Chang, J; Chen, X.; Glass, Z.; Gao, F.; Mao, L.; Wang, M; Xu, Q. Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing, Account of Chemical Research, 2019, 52 (3), pp 665–675.

Chang ZM, Wang Z, Shao D, Yue J, Xing H, Li L, Ge M, Li M, Yan H, Hu H, Xu Q, Dong WF. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. ACS Appl Mater Interfaces.* 2018 Apr 4;10(13):10656-10663.

Tang, R.; Wang, M.; Ray, M.; Jiang, Y.; Jiang, Z.; Xu, Q.; Rotello, V. M. “Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags” J. Am. Chem. Soc. 2017, 139 (25), pp 8547–8551.

Xu, Q.; Neufeld, C. I. “Pulling Cancer Cells Apart with a Net of Nanofibers.”, Chem*, 2017, 2, 167–168.

Wang, M.; Zuris, J. A.; Meng, F.T.; Rees, H.; Deng, P.; Gao, X.; Pouli, D.; Wu, Q.; Georgakoudi, I.; Liu, D. R.; Xu, Q. “Efficient Genome Editing Protein Delivery using Bioreducible Lipid-like Materials”, Proceedings of the National Academy of Sciences, 2016, 113, 2868-2873.

Jabbari, E. *; Leijten, J.; **Xu, Q. *;** Khademhosseini, A.* “The matrix reloaded: the evolution of regenerative hydrogels”, Materials Today, 2015, Nov.

Dai, X.; Knupp, S.; Xu, Q., “Patterning Nanoparticles in 3D Matrix using Electric-Field Assisted Gel Transferring (EFAGT)”, Langmuir,* 2012, 28, 2960-2964.