HOST GENETICS AND INFECTIOUS DISEASE

Viral reservoir and reservoir-like species play an important role in ecology and evolution. However, wild species are hugely understudied and underrepresented in basic research. Using a combination of our own field samples, collaborations and published genomic data, we are developing tools to investigate correlates of influenza disease resistance and/or susceptibility among multiple species. We are leading a comparative genomics project to develop and study high resolution genomes for grey and harbor seals. We are also developing a generalizable pipeline using diverse avian genomes for large-scale comparative genomics projects. These bioinformatic approaches can then be directly followed up in the wet lab with our extensive wildlife and surveillance samples. We seek to provide unbiased host factors associated with viral resistance/susceptibility while contributing valuable tools for all investigators.

In addition we are collaborating with Dr. Kristina Cammen to look at genetic bottlenecks and the impact of recovery and recolonization on the genetic diversity of pinnipeds after local extirpation.