Cellular Mechanics and Angiogenic Induction

BOSTON and CAMBRIDGE (April 26, 2010) — Pericytes, the contractile cells surrounding capillaries, may use mechanical forces to initiate angiogenesis, the “sprouting” of new blood vessels, according to researchers at Tufts University School of Medicine (TUSM) and the Massachusetts Institute of Technology (MIT). The study, published in Journal of Physics: Condensed Matter, is among the first to examine mechanical signaling by pericytes as a potential driver of angiogenesis, which is crucial in the progression of cancer, diabetic retinopathy, and age-related macular degeneration.


Vascularized microfluidic networks

The TIWR has just published a study focused on creating biodegradable vascularized microfluidic networks in silk fibroin. Authors include Jeffrey Borenstein, Katie Megley, Kim Wall, Eleanor Pritchard, David Truong, David Kaplan, Sarah Tao, and Ira Herman. These integrated vascular networks will sustain living human skin equivalents for personalized regenerative medicine and wound healing. Here’s the link http://www.mdpi.com/1996-1944/3/3/1833/

About Our Center

Ira M. Herman, Ph.D. TIWR Director

Ira M. Herman, Ph.D. TIWR Director

Welcome to The Tufts Center for Innovations in Wound Healing Research (TIWR) at Tufts University School of Medicine. We launched TIWR in 2006, after recognizing that significant advances in our understanding the biology of wound healing had yet to be fully exploited in the technologies that are currently available for patient or combat casualty care.

Our group includes basic science and clinical investigators at Tufts University united with colleagues from partnering institutions. This multi-investigator and cross-disciplinary regenerative medicine- and wound healing-based initiative combines expertise in epithelial cell and extracellular matrix biology, the angiogenesis of wound healing, stem cell biology, and the cellular biology of wound healing/tissue regeneration. TIWR investigators and clinician scientists are now leveraging their expertise in regenerative medicine and wound repair science with cutting-edge technologies in biomaterials sciences and nano-fabrication processing to create innovative, personalized wound healing therapeutics, including ‘next-generation’ wound care products for civilian or soldier use.

We have several projects underway. Find out more about TIWR, our research, our partners and our mission, by clicking through this website, and please feel free to contact us with comments or questions.  Thanks, Ira