Composition and method for generating immunity to Borrelia burgdorferi

Lin, Y.P. and Kaspars Tars. US20190201516A1. Granted by United States Patent and Trademark Office

The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, the common tick-borne disease in the U.S. and Europe. No potent human vaccine is currently available. In this invention, we eliminate Factor H-binding activity of a Lyme borreliae protein CspZ and identify this mutated protein as a potent vaccine candidate.