The research at the integrated Biofunctional Imaging and Therapeutics Laboratory (iBIT Lab) focuses on utilizing non-invasive acoustic and optical imaging techniques with nanomaterials and biological models to understand the structural, functional, molecular and biomechanical heterogeneity of pathologies such as cancer. The triangle in the iBIT lab logo depicts the three directions where biofunctional imaging will be utilized to improve patient care: 1. Guide surgical methods 2. Predict therapeutic response and 3. Design effective therapeutic strategies. We are a team of Biomedical engineers with interdisciplinary background in Electronics, signal processing, molecular biology, optics and nanotechnology with collaborations with clinicians and researchers in the Boston Area. We are always looking for enthusiastic highly motivated individuals to join our team.
We are actively looking for graduate students to join our Group. Students interested in non-invasive ultrasound and optical imaging with focus on image-guided therapies and cancer research, email Prof. Mallidi your CV. We also have openings for Postdoctoral fellows. Check out the current openings here.
RO1 Grant Awarded!
Excited to share the news that we received R01 grant from the NIH National Cancer Institute to work on photoacoustic image-guided photodynamic therapy with nanodroplets to improve outcomes in head and neck cancer in collaboration with Nanohybrids Inc!
Photoacoustic Monitoring of Suboptimal Therapy Efficacy
Just published from the iBIT Lab in the Frontiers in Oncology Cancer Imaging and Image-directed Interventions special issue. Read here
Publication on Biodegradable Nanoparticles for PDT
Publication hot off the press from iBIT lab – Biodegradable Eutectic Gallium–Indium Nanoparticles fabricated via simple green sonication methods can be used for delivery of photosensitizers to the tumor for localized Photodynamic Therapy. Read here
Dr. Mallidi Speaks at Columbia
Dr. Mallidi presents on ultrasound guided photoacoustic imaging for treatment at Columbia’s BME Seminar Series. Watch here!
R21 Grant Awarded
The iBIT Lab along with the Shelly Foster Group at UMASS Boston are the proud recipients of an R21 Grant!
Light on Tissue!
Light on Tissue cool stuff happening in lab!
Allison and Abby pass Master’s ORP
Congrats to the iBIT Lab’s first Master’s students!
Publication on Frontiers in Placenta Imaging
Checkout our review paper here, headed by Chris Nguyen, on placenta imaging with Dr. Mary Wallingford group! We are excited about this collaboration and new directions for photoacoustic and photodynamic therapy!
Study on LED-Photoacoustic Imaging for imaging tumor vasculature is now published
Access paper here. Traditionally photoacoustic systems employ expensive and bulky class IV lasers with low pulse repetition rate, due to which its availability for preclinical cancer research is hampered. In this study, we evaluated the capability of a Light-Emitting Diode (LED)-based PA and ultrasound (US) imaging system for monitoring heterogeneous microvasculature in tumors (up to 10 mm in depth) and quantitatively compared the PA images with gold standard histology images. Analysis of 30 regions of interest in tumors from different mice showed a statistically significant R-value of 0.84 where the areas with high blood vessel density had high PA response while low blood vessel density regions had low PA response. Our results confirm that LED-based PA and US imaging can provide 2D and 3D images of tumor vasculature and the potential it has as a valuable tool for preclinical cancer research.
NIH S10 Award for Dr. Mallidi
Dr. Mallidi has received an S10 award to setup a small animal imaging core at the Medford Campus! The first instrument in the core is FujiFILM VisualSonics Ultrasound and photoacoustic imaging instrument
Chris & Marvin pass Qualifiers
iBIT Labs first batch of graduate students- Chris Nguyen and Marvin Xavierselvan pass the PhD qualifiers! Congratulations!
We are on Tufts NEWS!
UG Kelsey Detels wins the Audrey Butvavy Gruss Science Award
Congratulations Kelsey!She won the Audrey Butvavy Gruss Science Award for Juniors/seniors for the year 2020. Awarded annually to a student who has demonstrated outstanding academic work in any of the sciences and who is a scholarship recipient. This award was established in 1992 by Audrey Butvay Gruss, an alumna of Jackson College. Working in the iBIT lab since last summer, Kelsey has been instrumental in helping with setting up the lab and the cell inventory for the lab. Read more about it here
Paper Published in Particle!
First paper of the collaboration with Dr. Michelle Foster at UMass Boston is now published in Particle . Here we utilized novel nanoparticles for image-guided drug delivery
Paper Published in JBO!
Our work on understanding mutual impact of dyes on photoacoustic contrast and photodynamic therapy is now published in Journal of Biomedical Optics!
Recognition in IEEE Women in Photonics Magazine
Dr. Mallidi was recognized as the IEEE Women in Photonics Member of the month for her work in image-guided therapeutics, low cost photoacoustic imaging and photodynamic therapy (more…)
Early Investigator Award at IPA
Dr. Mallidi wins the Early Investigator Award from the International Photodynamic Therapy Association. Checkout the various news channels on the award
First Grant to the iBIT Lab
First grant of the iBIT lab with Dr. Michelle Foster at University of Massachusetts Boston is funded. We are excited to work together on biodegradable nanoparticles for photodynamic therapy!
Paper published in ACS Sensors!
- Check out our recent publication in ACS Sensors – photoacoustic imaging of DNA nanosensors with Prof. Heather Clark at Northeastern University.
iBIT Lab at SPIE Photonics West
- Marvin won the SPIE Student travel award!
- Prof. Mallidi chaired a session in the Photodynamic Therapy Conference.
Converging on Cancer At Tufts 2019 Meeting
Prof. Mallidi presented at the “Converging on Cancer at Tufts” Meeting, Tufts University, Medford MA
UG Co-op students join lab
Brett Tierney, Tala Hefzi and Sarah Byron join the lab as UG co-op students. They are currently a students at Wentworth Institute of Technology.