Peer reviewed publications


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*Authors have equal contribution

#Co-corresponding senior authors

Tufts Graduate students/Postdocs in blue font 

Tufts Undergraduate students in green font


54.  A. Paul, S. Mallidi, “U-Net enhanced real-time LED-based photoacoustic imaging.” J. Biophotonics 2024, e202300465 (Link here); Pre-print at Authoria (Link here)


53. A. Sweeney, A. Arora, S. Edwards, S. Mallidi, “Ultrasound-guided Photoacoustic image Annotation Toolkit in MATLAB (PHANTOM) for preclinical applications” bioRxiv Pre-print, 2023. (Link here)

52. M.A. Saad, S. Grimaldo-Garcia, A. Sweeney, S. Mallidi, T. Hasan, “A Dual Function Antibody Conjugate Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids.” Bioconjugate Chemistry, 2023. (Link here)

51. S. John, S. Hester, M. Basij, A. Paul, M. Xavierselvan, M. Mehrmohammadi, S. Mallidi,
“Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.” Photoacoustics, Vol 32, 2023. (Link here)

50. S. Khan, B. Song, S. Mallidi, S. Li, H. Liu, M. A. B. Hussain, S. A. Siddiqui, A. P. Khan, K. Akhtar, S. A. Siddiqui, S. A. Hasan, C. Hopper, S. G. Bown, R. Liang, T. Hasan, J. P. Celli, “Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance.” J. Biomed. Opt. Vol 28, 2023. (Link here

49. D.M. Sankepalle, B. Anthony, S. Mallidi, “Visual inertial odometry enabled 3D ultrasound and photoacoustic imaging,” Biomed. Opt. Express, Vol 14, 2023. (Link here)


48. C.D. Nguyen, S. Edwards, T.W. Iorizzo, B.N. Longo, A. Yaroslavsky, D. Kaplan, S. Mallidi, “Investigation of silk as a phantom material for ultrasound and photoacoustic imaging.” Photoacoustics, Vol 28, 2022. (Link here)

47. S. Early, M.A. Saad, S. Mallidi, A. Mansour, R. Seist, T. Hasan, K.M. Stankovic, “A fluorescent photoimmunoconjugate for imaging of cholesteatoma”. Sci Rep, Vol 12, 2022. (Link here)

46. A. Claus*, A. Sweeney*, DM. Sankepalle, B. Li, D. Wong, M. Xavierselvan, S. Mallidi*,  “3D Ultrasound-Guided Photoacoustic Imaging to Monitor the Effects of Suboptimal Tyrosine Kinase Inhibitor Therapy in Pancreatic Tumors”. Front Oncol, Vol 12,  2022. (Link here)                                                                                         

45. S. S. Hafiz*, M. Xavierselvan*, S. Gokalp*, D. Labadini, S. Barros, J. Duong, M. Foster, and S. Mallidi, “Eutectic Gallium–Indium Nanoparticles for Photodynamic Therapy of Pancreatic Cancer”. ACS Applied Nano Materials e-Print, Vol 5, 2022. (Link here) *Authors contributed equally

44. I. Turchin, S. Bano, M. Kirillin, A. Orlova, V. Perekatova, V. Plekhanov, E. Sergeeva, D. Kurakina, A. Khilov, A. Kurnikov, P. Subochev, M. Shirmanova, A. Komarova, D. Yuzhakova, A. Gavrina, S. Mallidi, T. Hasan, “Combined Fluorescence and Optoacoustic Imaging for Monitoring Treatments against CT26 Tumors with Photoactivatable Liposomes”. Cancers, Vol 14, 2022. (Link here

43. S.A. Siddiqui, S. Siddiqui, M A B Hussain, S. Khan, H. Liu, K. Akhtar, S. A. Hasan, I. Ahmed, S. Mallidi, A. P. Khan, F. Cuckov, C. Hopper, S. Bown, J. P. Celli, and T. Hasan, “Clinical evaluation of a mobile, low-cost system for fluorescence guided photodynamic therapy of early oral cancer in India”, Photodiagnosis and Photodynamic Therapy,
Vol 38, 2022. (Link here


42. M. Xavierselvan, J. Cook, J. Duong, N. Diaz, K. Homan and S. Mallidi, “Photoacoustic nanodroplets for oxygen enhanced photodynamic therapy of cancer”, Photoacoustics, Vol 25, 2021. (Link here)

41. M.A. Saad, M. Xavierselvan, H.A. Sharif, S. Selfridge, R. Pawle, M. Varvares, S. Mallidi, T. Hasan, “Dual Function Antibody Conjugates for Multimodal Imaging and Photoimmunotherapy of Cancer Cells”. Photochem Photobiol, Vol 98, 2021. (Link here)

40. R. Bulsink, M. Kuniyil Ajith Singh, M. Xavierselvan, S. Mallidi, W. Steenbergen, K. J. Francis, “Oxygen Saturation Imaging Using LED-Based Photoacoustic System”. Sensors, Vol 21, 2021. (Link here)

39. G. Obaid, K. Samkoe, K. Tichauer, S. Bano, Y. Park, Z. Silber, S. Hodge, S. Callaghan, M. Guirguis, S. Mallidi, B. Pogue and T. Hasan, “Is Tumor Cell Specificity Distinct from Tumor Selectivity In Vivo?: A Quantitative NIR Molecular Imaging Analysis of Nanoliposome Targeting”. Nano Research, Vol 14, 2021. (Link here)


38. M. Xavierselvan, MKA. Singh, S. Mallidi,  “Imaging tumor vasculature using LED-based photoacoustic system”, Proc. SPIE, 2020. 

37. FK. Joseph, M. Xavierselvan, MKA. Singh, S. Mallidi, C. van der Laken, F. van de Loo, and W. Steenbergen “LED-based photoacoustic imaging for early detection of joint inflammation in rodents: towards achieving 3Rs in rheumatoid arthritis research”, Proc. SPIE, 2020. 

36. C. D. Nguyen, A. Correia-Branco, N. Adhikari, E. Mercan, S. Mallidi# and M. C. Wallingford#, “New Frontiers in placenta tissue imaging”, EMJ Radiol, Vol 1, 2020. (Link here)

35. M. Xavierselvan, M. K. A. Singh and S. Mallidi, “In Vivo Tumor Vascular Imaging with Light Emitting Diode-Based Photoacoustic Imaging System”, Sensors, Vol 20, 2020. (Link here)

34. M. Kuriakose; C. D. Nguyen; M. K. A. Singh; S. Mallidi, “Optimizing Irradiation Geometry in LED-Based Photoacoustic Imaging with 3D Printed Flexible and Modular Light Delivery System”. Sensors, Vol 20, 2020. (Link here

33. R. L. Goldstein, M. C. McCormack, S. Mallidi, G. Runyan, M. A. Randolph, W. G. Austen Jr and R. W. Redmond, “Photochemical Tissue Passivation of Arteriovenous Grafts Prevents Long-term Development of Intimal Hyperplasia in a Swine Model” [published online ahead of print, 2020 May 8]. J Surg Res, Vol 253, 2020. (Link here

32. S. S. Hafiz, D. Labadini, R. Riddell,  E.P. Wolff, M. Xavierselvan, P. K. Huttunen, S. Mallidi, M. Foster, “Surfaces and Interfaces of Liquid Metal Core–Shell Nanoparticles under the Microscope”. Part. Part. Syst. Charact, Vol 37, 2020. (Link here

31. S. AnbilM. PigulaH-C. HuangS. MallidiM. BroekgaardenY. BagloP. DeSilvaD. M. SimeoneM. Mino-KenudsonE. V. Maytin, I. Rizvi and T. Hasan,”Vitamin D receptor activation and photodynamic priming enable durable low-dose chemotherapy”

30. S. Khan, M. A. Bilal Hussain, A. P. Khan, H. Liu, S. Siddiqui, S. Mallidi, P. L. Alacron, L. Daly, G. Rudd, F. Cuckov, C. Hopper, S. G. Bown, K. Akhtar, S. A. Hasan, S. A. Siddiqui, T. Hasan and J. P. Celli, “Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer,” J. Biomed. Opt. Vol 25, 2020. (Link here)

29. L. Z. Petrovic*, M. Xavierselvan*, M. Kuriakose*, M. D. Kennedy, C. D. Nguyen, J. J. Batt, K. B. Detels, S. Mallidi, “Mutual impact of clinically translatable near-infrared dyes on photoacoustic image contrast and in vitro photodynamic therapy efficacy,” J. Biomed. Opt. Vol 25, 2020. (Link here)

28. S.C. Hester, M. Kuriakose, C. D. Nguyen, and S. Mallidi, “Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer”. Photochem Photobiol, Vol 96, 2020. (Link here)


27. S. Mallidi, A.P. Khan, H. Liu , L. Daly , G. Rudd , P. Leon , S. Khan , B. Hussain , S. Hasan , S. Siddique , K. Akhtar , M. August , M. Troulis , F. Cuckov , J. Celli and T. Hasan, “Platform for ergonomic intraoral photodynamic therapy using low-cost, modular 3D-printed components: Design, comfort and clinical evaluation”, Scientific Reports 2019 (Link here)

26. G. Obaid, S.Bano, S. Mallidi, M. Broekgaarden, J. Kuriakose, Z. Silber, A-L. Bulin, Y. Wang, Z. Mai, W. Jin, D. Simeone, and T.Hasan,”Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia?” Nano Letters . (Link here)

25. J. Morales, R. H. Pawle, N. Akkilic, Y. Luo, M. Xavierselvan, R. Albokhari, I. Andrew , C. Calderon, S. Selfridge, R. Minns, L. Takiff, S. Mallidi, and H. A. Clark, “DNA-Based Photoacoustic Nanosensor for Interferon Gamma Detection,” ACS Sensors Article ASAP (Link here)

24. D. Kurakina, M. Kirillin, V. Perekatova, V. Plekhanov, A. Orlova, E. Sergeeva, A. Khilov, A. Nerush, P. Subochev,  S. Mallidi, I. Turchin and T. Hasan, “Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study”. Appl. Sci. 2019, 9, 1918.  (Link here)

23. Yu. Kirillin, D. A. Kurakina, V. V. Perekatova, A. G. Orlova, E. A. Sergeeva, A. V. Khilov, P. V. Subochev, I. V. Turchin, S. Mallidi, T. Hasan, “Complementary bimodal approach to monitoring of photodynamic therapy with targeted nanoconstructs: numerical simulations”, Kvantovaya Elektronika, 49:1 (2019), 43–51 [Quantum Electron., 49:1 (2019), 43–51 (Link here)


22. M. Pigula, H-C Huang*, S. Mallidi*, S. Anbil, J. Liu, Z. Mai and T. Hasan, “Size-dependent Tumor Response to Photodynamic Therapy and Irinotecan Monotherapies Revealed by Longitudinal Ultrasound Monitoring in an Orthotopic Pancreatic Cancer Model”, Photochem Photobiol. 2018 doi: 10.1111/php.13016. [Epub ahead of print] #Equal contribution (Link here)

21. H. Liu, L. Daly, G. Rudd, A.P. Khan, S. Mallidi,Y. Liu, F. Cuckov,T. Hasan, J. P. Celli, “Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings”, Lasers Surg Med. 2018 Aug 31. doi: 10.1002/lsm.23019. [Epub ahead of print] – Selected by the Editor as the highlight article for the issue  (Link here)

20. R. N. Goldstone, M. C. McCormack, R. L. Goldstein, S. Mallidi, M.A. Randolph, M. T. Watkins, R. W. Redmond and W. G. Austen Jr, “ Photochemical Tissue Passivation Attenuates AV Fistula Intimal Hyperplasia”, Annals of Surgery, 267(1):183-188, 2018. doi: 10.1097/SLA.0000000000002046 (Link here)


19. H-C Huang*, S.Mallidi*, C-T. Chiang, Z. Mai and T. Hasan, “Photodynamic therapy synergizes with irinotecan to overcome compensatory mechanisms and improve treatment outcomes in pancreatic cancer”, Cancer Research,76(5):1066-77, 2016. #Equal Authorship (Link here)


18. S. Mallidi, Z. Mai, I. Rizvi, S. Arnason, J. Celli and T. Hasan, “PDT in low resource settings: A proof-of-principle in vivo study in a xenograft model of squamous cell carcinoma using LED illumination”, Journal of Biomedical Optics, 20(4): 048003, 2015. PMID:25909707 (Link here)

17. S. Mallidi, B. Q. Spring and T. Hasan, “Optical Imaging, Photodynamic Therapy and Optically-triggered Combination treatments,” The Cancer Journal, 21(3): 194-205, 2015. PMID:26049699 (Link here)

16. S. Mallidi, S. Kim, A. Karpiouk, P. Joshi, K. Sokolov, and S. Emelianov, “Visualization of molecular composition and functionality of cancer cells using nanoparticle-augmented ultrasound-guided photoacoustics,” Photoacoustics, vol. 3: 26-34, 2015 doi:10.1016/j.pacs.2014.12.003, 2015. (Link here)

15. S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of Tumor Recurrence and Therapy Monitoring using Ultrasound-Guided Photoacoustic Imaging,” Theranostics, vol. 5, no. 3, pp. 289-301, 2015. Publisher’s Version Abstract – Selected for Journal Cover Art (Link here)


14. S. Mallidi, S. Anbil, S. Lee, D. Manstein, S. Elrington, G. Kositratna, D. Schoenfeld, B. W. Pogue, S. J. Davis, and T. Hasan, “Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema.” Journal of Biomedical Optics, vol. 19, pp. 028001, 2014. (Link here)

13. M. Frenette, M. Hatamimoslehabadi, S. Bellinger-Buckley, S. Laoui, J. La, S. Bag, S. Mallidi, T. Hasan, B. Bouma, C. Yelleswarapu, and J. Rochford, “Shining light on the dark side of imaging: excited state absorption enhancement of a bis-styryl BODIPY photoacoustic contrast agent.” Journal of the American Chemical Society, vol. 136, pp. 15853–15856, 2014. (Link here)


12. M. Mehrmohammadi, J. Oh, S. Mallidi, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging using ultrasmall magnetic nanoprobes.” Molecular imaging, vol. 10, pp. 102–110, 2011 (Link here)

11. M. Qu, S. Mallidi, M. Mehrmohammadi, R. Truby, K. Homan, P. Joshi, Y. Chen, K. Sokolov, and S. Emelianov, “Magneto-photo-acoustic imaging.” Biomedical optics express, vol. 2, pp. 385–396, 2011.(Link here)

10. C. L. Bayer, Y. – S. Chen, S. Kim, S. Mallidi, K. Sokolov, and S. Y. Emelianov, “Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods.” Biomedical optics express, vol. 2, pp. 1828–1835, 2011. (Link here)

9. S. Mallidi, G. P. Luke, and S. Y. Emelianov, “Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance.” Trends in Biotechnology, vol. 29, pp. 213–221, 2011. (Link here)


8. P. Rai, S. Mallidi, X. Zheng, R. Rahmanzadeh, Y. Mir, S. Elrington, A. Khurshid and T. Hasan, “Development and applications of photo-triggered theranostic agents.” Advanced Drug Delivery Reviews, vol. 62, pp. 1094–1124, 2010. (Link here)

7. T. Wang, S. Mallidi, J. Qiu, L. Ma, A.S. Paranjape, J. Sun, R. V. Kuranov, K. P. Johnston, and T. E. Milner, “Comparison of pulsed photothermal radiometry, optical coherence tomography and ultrasound for melanoma thickness measurement in PDMS tissue phantoms”, Journal of Biophotonics, 4: 335–344, 2010. PMID: 20954204   (Link here)

6. S. J. Yoon, S. Mallidi, J. M. Tam, J. O. Tam, A. Murthy, K. P. Johnston, K. V. Sokolov, and S. Emelianov, “Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging.” Optics letters, vol. 35, pp. 3751–3753, 2010.  (Link here)

5. K. Homan, S. Kim, Y. – S. Chen, B. Wang, S. Mallidi, and S. Y. Emelianov, “Prospects of molecular photoacoustic imaging at 1064 nm wavelength.” Optics letters, vol. 35, pp. 2663–2665, 2010.  (Link here)



4. S. Mallidi, et al., “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer.” Nano Letters, vol. 9, pp. 2825–2831, 2009. (Link here)

3. S. Mallidi and S. Y. Emelianov, “Photoacoustic technique to measure beam profile of pulsed laser systems.” Review of Scientific Instruments, vol. 80, pp. 054901, 2009. (Link here)

2. A.B. Karpiouk, S.R. Aglyamov, S. Mallidi, J. Shah, W.G. Scott, J. Rubin, and S. Emelianov, “Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies.” Journal of Biomedical Optics, vol. 13, pp. 054061, 2008. (Link here)

1. S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Y. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles.” Optics Express, vol. 15, pp. 6583–6588, 2007. (Link here)