The research at the integrated Biofunctional Imaging and Therapeutics Laboratory (iBIT Lab) focuses on utilizing non-invasive acoustic and optical imaging techniques with nanomaterials and biological models to understand the structural, functional, molecular and biomechanical heterogeneity of pathologies such as cancer. The triangle in the iBIT lab logo depicts the three directions where biofunctional imaging will be utilized to improve patient care: 1. Guide surgical methods 2. Predict therapeutic response and 3. Design effective therapeutic strategies. We are a team of Biomedical engineers with interdisciplinary background in Electronics, signal processing, molecular biology, optics and nanotechnology with collaborations with clinicians and researchers in the Boston Area. We are always looking for enthusiastic highly motivated individuals to join our team.
We are actively looking for graduate students to join our Group. Students interested in non-invasive ultrasound and optical imaging with focus on image-guided therapies and cancer research, email Prof. Mallidi your CV. We also have openings for Postdoctoral fellows. Check out the current openings here.
Valli joins the other great minds of photoacoustic imaging for dinner
Our lab visited San Fransisco to attend the SPIE Photonics West 2023 Conference! Chris, Skye, and Avijit gave great talks along with Marvin and Deeksha’s poster presentations! It was amazing to meet researchers from all over the world working on the development of Photoacoustic Imaging and Photodynamic Therapy.
Congratulations to Avijit, Chris, and Deeksha who all received travel awards to present their research at the 2023 SPIE Photonics West Congress in San Fransisco.
Loved having the opportunity to share the research we do with the rest of the Tufts BME department
Amazing gathering and scientific discussions happened today when the Optics groups of Tufts visited Northeastern
Tufts University Biomedical Engineering Research Scholars (TUBERS) Program is for dedicated, academically-talented high school students. Some Tubers came to visit the lab and learn more about our research this summer!
Just published from the iBIT Lab in the Frontiers in Oncology Cancer Imaging and Image-directed Interventions special issue. Read here
Congratulations to our very own Allison Sweeney for winning the New England Science Symposium’s Prophet Genomics Translational Research Award!
Publication hot off the press from iBIT lab – Biodegradable Eutectic Gallium–Indium Nanoparticles fabricated via simple green sonication methods can be used for delivery of photosensitizers to the tumor for localized Photodynamic Therapy. Read here
Congratulations to our Graduates! Special mention to Abigail Claus and Allison Sweeney, the first set of Master’s students to graduate from iBIT Lab! Abby is heading to Invicro and Allison decided to stay with us longer to research further on photoacoustics
The BME faculty recipient of this year’s award is Professor Srivalleesha Mallidi!
BME Capstone Best senior design project of the Year! Congratulations to these amazing young researchers in the Oudin Lab, and our very own Elli Diaz! 
Dr. Mallidi has received a Rising Star Award from the World Molecular Imaging Congress. The award recognizes the contributions of outstanding women scientists in their early careers who demonstrate exceptional potential for contributions to the field of molecular imaging.
Dr. Mallidi presents on ultrasound guided photoacoustic imaging for treatment at Columbia’s BME Seminar Series. Watch here!
Local high school students come to tour the lab and learn about the science we do!
Checkout our review paper here, headed by Chris Nguyen, on placenta imaging with Dr. Mary Wallingford group! We are excited about this collaboration and new directions for photoacoustic and photodynamic therapy!
Access paper here. Traditionally photoacoustic systems employ expensive and bulky class IV lasers with low pulse repetition rate, due to which its availability for preclinical cancer research is hampered. In this study, we evaluated the capability of a Light-Emitting Diode (LED)-based PA and ultrasound (US) imaging system for monitoring heterogeneous microvasculature in tumors (up to 10 mm in depth) and quantitatively compared the PA images with gold standard histology images. Analysis of 30 regions of interest in tumors from different mice showed a statistically significant R-value of 0.84 where the areas with high blood vessel density had high PA response while low blood vessel density regions had low PA response. Our results confirm that LED-based PA and US imaging can provide 2D and 3D images of tumor vasculature and the potential it has as a valuable tool for preclinical cancer research.
The Vevo LAZR-X ultrasound and photoacoustic imaging system is here! We recently received NIH funds to purchase this equipment. We cannot wait for the labs to fully reopen to hook this system up and look inside of tumors!
Does angle of illumination really matter in LED based photoacoustic imaging for deep tumor imaging? Check out our new publication here in Sensors that answers this question with 3D printed flexible angle holder!
Our work with Redmond team at MGH is now published in JSR. We showcase the utility of high frequency ultrasound imaging in cardiovascular research – particularly to measure intima/media thickness and blood flow in diseased and treated Pig vessels in vivo. Read the paper here
Congratulations Kelsey!She won the Audrey Butvavy Gruss Science Award for Juniors/seniors for the year 2020. Awarded annually to a student who has demonstrated outstanding academic work in any of the sciences and who is a scholarship recipient. This award was established in 1992 by Audrey Butvay Gruss, an alumna of Jackson College. Working in the iBIT lab since last summer, Kelsey has been instrumental in helping with setting up the lab and the cell inventory for the lab. Read more about it here
Dr. Mallidi was recognized as the IEEE Women in Photonics Member of the month for her work in image-guided therapeutics, low cost photoacoustic imaging and photodynamic therapy
Harvard Research Tech Marvin Xavierselvan and Dr. Mallidi win the Travel Award from VisualSonics Inc and the Prestige People’s Choice Award at the IPA conference in Boston.
Wellman Lab visit with the BME 51/251 Class. Thank you Dr. Martin Villiger and Dr. Tayyaba Hasan lab for the time and resources to make this trip possible.
Celebrating the start of Spring and the lab- iBIT team first lunch gathering at Yoshi Restaurant.
