People

March 2018 group photo.
(L-R) Seated: Venkatesh, Trevor, Joe. Standing: Todd, Bruno, Aaron, Sean, Brett, Prof. Nair, Zac, Vikas.


Principal Investigator Assistant Professor Nikhil (Nik) U. Nair (Nikhil.Nair_at_tufts_dot_edu)

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Office:
Science &  Technology Center 276
4 Colby St., Medford, MA 02155

Appointment(s)
2013 – Assistant Professor, Chemical & Biological Engineering, Tufts University, MA
2017 – Adjunct Assistant Professor, CDMB Program, Sackler School of Biomedical Sciences, Tufts University

Education
2013 Post-doc, Microbiology & Immunobiology, HMS, Boston, MA
2010 PhD, Chemical & Biomolecular Engineering, UIUC, IL
2006 MS, Chemical & Biomolecular Engineering, UIUC, IL
2003 BS, Chemical & Biomolecular Engineering, Cornell University, NY

 

 

Honors and Awards

2016 NIH Director’s New Innovator Award
2016 Tufts Faculty with Significant Impact on Undergraduate Students
2009 Hanratty Travel Award, UIUC
2008-2009 Mavis Memorial Fund Scholarship Award, UIUC
2008-2009 Drickamer Endowment Fund, UIUC
2008, 2009 Annual ChBE Graduate Research Symposium Award, UIUC
2008 Best Oral Presentation in the CMB/MBTG Research Symposium, UIUC
2008 Hanratty Travel Award, UIUC


Post-doctoral Scholars and Visting Scientists

Vikas D. Trivedi – Post-doc (Vikas.Trivedi_at_tufts_dot_edu) (Summer ’17 – )
Vikas is graduate in Chemistry and Biochemistry and postgraduate in Biochemistry from Mumbai University. He completed his PhD with a thesis on “Biochemical and evolutionary aspects of carbaryl degradation in Pseudomonas sp.” from Indian Institute of Technology B, Mumbai, India. He joined the lab in the year 2017 as a postdoctoral scholar and will be working at the interface of chemical and synthetic biology to evaluate the role of bacteriocins within microbial communities.


Graduate Students

gradGopinarayananVenkatesh Endalur Gopinarayanan – Biot PhD student (Venkatesh.Endalur_Gopinarayanan_at_tufts_dot_edu) (Fall ’12 – )
Venkatesh completed his bachelors and masters in Biotechnology from Anna University, India. During undergrad, he worked in screening Staphylococcus aureus nasal carriage among healthy individuals for detection of PVL gene, a major virulence determinant at Indian Council of Medical Research (ICMR), Chennai. Later in his masters, he studied the flux shift between native and recombinant Lactobacillus reuteri and identified ways to increase the specific and total productivity of 1, 3-propanediol from the microbe at Center for Biotechnology, Anna University. He joined Tufts in the fall of 2012 and is co-advised by Prof Kyongbum Lee. He is currently working to incorporate xylose regulation in S. cerevisiae using protein and metabolic engineering strategies.

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Josef R. Bober – ChE PhD student (Josef.Bober_at_tufts_dot_edu) (Fall ’13 – )
Josef joined the lab in 2013 after graduating with a BS in Chemical Engineering from Northeastern University. During his undergrad career, he interned as a process development engineer for Alkermes Pharmaceuticals and did part-time research with Harvard Medical School. Since starting at Tufts, Josef has been developing a novel biotic therapeutic for patients diagnosed with Galactosemia.

gradChappellTodd C. Chappell – Biot PhD student (Todd.Chappell_at_tufts_dot_edu) (Spring ’14 – )
Todd graduated in 2011 from the University of North Carolina Charlotte (UNCC) with a BA in architecture and BS in Biology with a Chemistry minor. At UNCC, Todd worked in a research lab studying the effects of multiple environmental stressors on estuarine marine bivalves by analyzing the concentration of key metabolites. Following graduation, he immediately moved into graduate studies at Tufts University as a Bioengineering MS student and in Fall 2014, he switched to the PhD program. Currently, he is researching sugar metabolism in E. coli as well as biotic therapeutics to combat infections in chronic wounds.

gradMaysZachary J. S. Mays – Biot PhD student (Zachary.Mays_at_tufts_dot_edu) (Fall ’14 – )
Zac joined the lab in 2014 with a BA in Biochemistry and Molecular Biology from Boston University and an MS in Biotechnology from Northwestern University.  His MS thesis involved a high-throughput screen for transcription factor activity throughout megakaryopoiesis. During his academic career, he interned for Eisai Pharmaceuticals and Sanofi Pasteur and later worked for BP Biofuels in lignocellulosic ethanol production. Since 2015 Zac has been developing a bacterial therapeutic to treat phenylketonuria in the Nair lab.

gradNascimentoBruno Motta Nascimento – Biot PhD student (Bruno.Motta_Nascimento_at_tufts_dot_edu) (Fall ’14 – )
Bruno has a BS and MS degree in Bioprocess Engineering and Biotechnology from the Federal University of Paraná (Brazil). As an undergrad, he worked in the Bioprocess lab with submerged fermentation of fungi and bacteria producing polysaccharides with antitumor activity. In the Molecular Biology Department, he also gained experience in this area by performing gene knockouts in Trypanosomatids. While completing masters, Bruno worked as a research trainee at Bio4 Soluções Biotecnológicas (Brazil), performing DNA fingerprinting of yeasts isolated from bioethanol plants. He was also responsible for cloning and expressing recombinant enzymes in yeasts. After joining the Nair lab in 2014 at Tufts, he has joined the project on microbial transcription regulation by abortive RNA fragments as well as the biosynthesis of high-performance materials using E. coli.

Trevor B. Nicks – Biot PhD student (Trevor.Nicks_at_tufts_dot_edu) (Fall ’17 – )
Trevor graduated from William Jewell College in 2017, earning a BA with honors in Biochemistry, Applied Critical Thought & Inquiry, and a minor in Business Administration. At Jewell, Trevor worked in the lab of Dr. Lilah Rahn-Lee where he completed a research project on retooling the omega-3 fatty acid pathway for biofuel production and developed the thermal-symbiosis model of reduced-genome evolution in Nanoarchaea. He also co-founded and was Chief Science Officer of Spira, Inc., a Cyanobacteria company and member of the IndieBio EU accelerator class of 2016. Trevor joined the lab in Fall 2017 and is currently exploring new types of cell-free system technologies.

Sean Sullivan – Biot PhD student (Sean.Sullivan_at_tufts_dot_edu) (Fall ’17 – )
Sean graduated from Colby College in 2011 with a BA in Biology and a minor in Mathematics. At Colby, he investigated possible mechanisms for the transfer of antibiotic resistance between environmental and fish pathogens in aquaculture settings with his advisor, Frank Fekete. After graduating, Sean worked at Quanterix developing the ability for their ultra-sensitive immunoassay instrument to run and detect the output of multiple assays simultaneously. Sean joined the lab in fall 2017 and is interested in engineering lactic acid bacterial species to act as therapeutic platforms to treat various disorders.

Aaron M. Love – part-time Biot PhD student (Aaron.Love_at_tufts_dot_edu) (Fall ’17 – )
Aaron joined the Nair lab in 2017 as a part-time PhD student and works full-time at ManusBio, a biotechnology company in Cambridge, MA recreating plant processes in microorganisms to produce natural ingredients through fermentation. He graduated in 2013 from Northwestern University with an MS in Biotechnology, where his research was focused on RNAi based therapeutics at the company Exicure in Skokie, IL. He also holds a BA in microbiology from Miami University (OH). Aaron is currently investigating fundamental effects of heterologous gene expression on microbial hosts.

Brett Irwin – BioE MS student (Brett.Irwin_at_tufts_dot_edu) (Fall ’17 – )
Brett joined the lab in 2017 after graduating from University at Buffalo with a B.S. in Biochemistry. During his undergraduate career, he worked to determine the role of Mlh1-Mlh3 in DNA mismatch repair to better understand the cause of trinucleotide repeat expansions in Saccharomyces cerevisiae. Brett is currently working to develop novel genetic engineering tools for lactic acid bacteria.


Undergraduate Students

Emma Meehan – ChBE ’21 (Emma.Meehan_at_tufts_dot_edu) (Spring ’18 – )
Emma is a current undergraduate Chemical Engineering student interested in biotechnology and pharmaceuticals. She is particularly interested in gene therapy, nanomaterials, and the drug development process. Outside of the classroom, Emma is an Executive Board Member of the Society of Women Engineers, the Webmaster for the Tufts AIChE chapter, and a member of Kappa Alpha Theta. She is currently working with Todd on developing E. coli consortia for metabolic engineering.


Alumni

Post-doc(s)

Dr. Entela Nako (Fall ’13-Spring ’14) – now an instructor in the Department of Biology at MIT (as of Mar’ 16).

Undergraduate(s)

Adam Helitzer, ChBE ’14 (Fall ’13-Spring ’14) – Integration Engineer at Epic (as of Aug ’16).

Elizabeth Paul (Intern from University of Maryland, Baltimore County, ChBE’17) (Summer ’15) – Back at UMBC (as of Aug ’16).

Marilyn Allen, ChBE ’16 (Fall ’14 – Fall ’15) – Graduate student at University of Maryland, Baltimore County (as of Aug ’16).

Jeremy Marcus, CS/Bio ’16 (Summer ’14 – Fall ’15) – At Draper Labs in Cambridge, MA (as of Aug ’16).

Kaelyn Vik, ChBE ’16 (Spring ’15 – Spring ’16) – At Agios Pharmaceuticals in Cambridge, MA (as of Aug ’16).

Cassidy Hubert, ChBE’17 (Fall ’15 – Spring ’17)

Karlos Zachary (REU student from University of Minnesota, Duluth, ChBE’19) (Summer ’17) – Back at UMinn (as of Aug ’17)

Emily Chicklis (REU student from Simmons College, Boston, A’18) (Summer ’17) – Back at Simmons (as of Aug ’17)

Kelsey-Clare Gallagher, ChBE ’18 (Fall ’16 – Spring ’18) – Finishing up her B.S. (as of Mar ’18)

High School Student(s)

Maya Vaishnaw (intern from Concord Academy) (Summer ’16) – Finishing high school (as of 8/16).


Old pictures of the lab:

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May 2015 group photo. (L-R) Front: Venkatesh, Zac, Prof. Nair, Jeremy, Kaelyn, Marilyn. Back: Bruno, Todd, Joe

April 2017 group photo. (L-R) Front: Venkatesh, Cassidy, Prof. Nair, Middle: Kelsey, Todd, Zac, Joe, Back: Bruno

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