Investigators at Tufts Center for Innovations in Wound Healing have recently reported that two bioactive peptides invented markedly promote wound healing in diabetic swine. The study carried out by a team of physicians and scientists at Tufts University’s School of Medicine and Tufts Medical Center demonstrate that the wound healing peptides convert non-healing wounds into those capable of closure by activating wound healing angiogenesis, promoting epidermal cell migration and growth while ‘re-balancing’ the wound bed’s protease and protease inhibitor profiles. The work, which recently published in the Journal of Translational Medicine (JTM) follows earlier work demonstrating safety and efficacy in cell-based assays and in murine models of impaired healing. A link to the JTM publication can be found here: Sheets et al, 2016
Recently, at Experimental Biology 2015 being held in Boston, MA. Jennifer Durham received honors for ‘Pericyte contractility controls endothelial cell cycle progression and sprouting: Insights into angiogenic switch mechanics’, which we published late last year. The work, which teaches how pericyte chemo-mechanics controls endothelial growth dynamics and angiogenic switching, not only represents a major padadigm-shift in our understanding the regulatory role that pericytes play in orchestrating microvascular morphogenesis; but, the work will enable our creating ‘next generation’ cellular therapies capable of modulating pathological or physiological angiogenesis. Congratulations to my outstanding colleagues: Jennifer Durham, Howard Surks, Brian Dulmovits. This is truly a great achievement, demonstrating the global attention our work is receiving while offering considerable new hope for all those in need of healing.
Professor Herman recently delivered a Henry Stewart Talk (HST) on dynamic reciprocity and wound healing. A link to the HST can be found here: http://hstalks.com/?t=BL1863792-Herman
Recent work ongoing in the Center for Innovations in Wound Healing Research now indicates that microvascular pericytes can ‘instruct’ capillary-derived endothelial cells, ‘switching’ the endothelium from a growth-arrested into a growth-promoted state. With this shift, there is a marked increase in angiogenic potential when specific features of the pericyte are altered via genetic and molecular means. With this manipulation, pericytes are mechanically altered in that the cells become more contractile and better able to activate angiogenesis in response to injury. These exciting findings have recently published in the American J Physiology-Cell Physiology.
Recently, Ira Herman was interviewed about the therapeutic potential of the wound healing peptides created at Tufts University’s Center for Innovations in Wound Healing Research. Here is the YouTube link to the interview with Professor Herman http://www.youtube.com/watch?v=KeLLxSfL5Q0
In a recent study, work ongoing in TIWR in collaboration with colleagues at the University of Virginia indicates that a vascular progenitor cell population derived from adipose is capable of protecting the retinal capillaries against the damaging effects of elevated oxygen. These pre-clinical findings lend strong support for the notion that pericyte-like cells derived from adipose may offer an innovative cell-based therapy for patients suffering with diabetic retinopathy or age-related macular degeneration.
The work was recently published in PLoS ONE http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0065691
‘Clinical Outlooks for Regenerative Medicine’, which was held in Boston, MA on June 19, 2012, was a remarkable event.. bringing industry and academic leaders together for an exciting program.
From the Alliance for Regenerative Medicine Meeting Website:
“As many regenerative medicine and cell therapy products move into clinical trials, a clearer understanding of how these products will be administered and how they will perform clinically is critical for achieving regulatory approval and ultimately, for commercialization. This meeting will bring together leading regenerative medicine companies with clinicians and investigators from major research establishments where clinical trials are being conducted, with a goal to enhance the understanding of the key issues facing these products as they approach the marketplace”
Recent work from the Tufts Center for Innovations in Wound Healing Research has revealed that two novel peptides combine to synergistically accelerate wound healing using an in vivo model of impaired healing. This work was recently published in PLoS One ( http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032146 ) and was recently covered globally ( https://www.google.com/search?q=novel+bioactive+wound+healing+peptide&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a )
Work ongoing at the Center for Innovations in Wound Healing Research was recently highlighted in Technology Review
Recent work reveals that wound healing dynamics are tightly and reciprocally regulated. In particular, cellular components within the epidermal and dermal wound microenvironments transduce signals that control extracellular matrix remodeling and wound healing dynamics. In turn, these cellular and extracellular signaling cascades control whether or to what extent wound repair progresses or is chronically impaired. In this recent report, we consider these key aspects of dynamic reciprocity.