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Ira Herman

Center Director Interview – Wound Healing Peptides and Therapeutic Innovation

Recently, Ira Herman was interviewed about the therapeutic potential of the wound healing peptides created at Tufts University’s Center for Innovations in Wound Healing Research.  Here is the YouTube link to the interview with Professor Herman   http://www.youtube.com/watch?v=KeLLxSfL5Q0

Pericytes are protective for retinal microvessels

In a recent study, work ongoing in TIWR in collaboration with colleagues at the University of Virginia indicates that a vascular progenitor cell population derived from adipose is capable of protecting the retinal capillaries against the damaging effects of elevated oxygen. These pre-clinical findings lend strong support for the notion that pericyte-like cells derived from [...]

TIWR Director to present at the Alliance for Regenerative Medicine

 ’Clinical Outlooks for Regenerative Medicine’, which was held in Boston, MA on June 19, 2012, was a remarkable event.. bringing industry and academic leaders together for an exciting program. From the Alliance for Regenerative Medicine Meeting Website: “As many regenerative medicine and cell therapy products move into clinical trials, a clearer understanding of how these [...]

Bioactive Wound Healing Peptides Promote Wound Healing In Vivo

Recent work from the Tufts Center for Innovations in Wound Healing Research has revealed that two novel peptides combine to synergistically accelerate wound healing using an in vivo model of impaired healing.  This work was recently published in PLoS One ( http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032146 ) and was recently covered globally ( https://www.google.com/search?q=novel+bioactive+wound+healing+peptide&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a )

Speeding Up The Healing Process

Work ongoing at the Center for Innovations in Wound Healing Research was recently highlighted in Technology Review

The Dynamics of Wound Healing

Recent work reveals that wound healing dynamics are tightly and reciprocally regulated. In particular, cellular components within the epidermal and dermal wound microenvironments transduce signals that control extracellular matrix remodeling and wound healing dynamics. In turn, these cellular and extracellular signaling cascades control whether or to what extent wound repair progresses or is chronically impaired. [...]

Bioactive Peptides Promote Wound Healing

Newly-created bioactive peptides promote wound healing through the growth of new blood vessels and epithelial tissue, such as skin. These wound-healing peptides, synthesized by researchers at the Tufts Center for Innovations in Wound Healing Research promote re-epithelialization and wound healing angiogenesis as reported online in Wound Repair and Regeneration News Release News Release

Cellular Adhesion and Cytoskeletal Linkers: Calcium Signaling, Proteases and Cellular Mechanics Impact Angiogenic Induction?

In a recent report that was published in Microvascular Research http://www.ncbi.nlm.nih.gov/pubmed/20709086 (ePub ahead of print), we have revealed a key relationship between the control of microvascular pericyte shape, contractility and mechanical stiffness. The work points to the pivotal role that the neutral cysteine protease family member, calpain I, is likely to be playing in modulating [...]

Putting The Squeeze On Cancer

Posted on: Tuesday, 15 June 2010, 09:35 CDT Cell contractions may be key to initiating new blood-vessel growth near tumors. Cancer researchers have been studying angiogenesis — the growth of new blood vessels — since the early 1970s, when Judah Folkman first theorized that tumors could be destroyed by cutting off their blood supply. For [...]

Cellular Mechanics and Angiogenic Induction

BOSTON and CAMBRIDGE (April 26, 2010) — Pericytes, the contractile cells surrounding capillaries, may use mechanical forces to initiate angiogenesis, the “sprouting” of new blood vessels, according to researchers at Tufts University School of Medicine (TUSM) and the Massachusetts Institute of Technology (MIT). The study, published in Journal of Physics: Condensed Matter, is among the [...]