Selected Publications:
3D Brain Model Development
- Functional bioengineered models of the central nervous system.
- Rouleau et al. Nat Rev Bioeng 1: 252 (2023).
- Innovations in 3D tissue models of human brain physiology and disease.
- Lovett et al. Adv Funct Mater. 30: 1909146 (2020).
- Functional characterization of three-dimensional cortical cultures for in vitro modeling of brain networks.
- Dingle et al. iScience 23: 101434 (2020).
- Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix.
- Sood et al. Sci Rep. 9: 17874 (2019).
- Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue.
- Sood et al. ACS Biomater Sci Eng. 2: 131 (2016).
- Expandable and rapidly differentiating human induced neural stem cell lines for multiple tissue engineering applications.
- Cairns et al. Stem Cell Reports 7: 557 (2016).
- Bioengineered functional brain-like cortical tissue.
- Tang-Schomer et al. PNAS 111: 13811 (2014).
- See more of our publications on 3D brain model development >>
Neurodegenerative Diseases
- 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease.
- Lomoio et al. Mol Psychiatry 28: 5390 (2023).
- Functional bioengineered tissue models of neurodegenerative diseases.
- Mullis and Kaplan. Biomaterials 298: 122143 (2023).
- 3D biocomposite culture enhances differentiation of dopamine-like neurons from SH-SY5Y cells: A model for studying Parkinson’s disease phenotypes.
- Fiore et al. Biomaterials 290: 121858 (2022).
- Potential Involvement of Varicella Zoster Virus in Alzheimer’s Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1.
- Cairns et al. J Alzheimers Dis 88: 1189 (2022).
- Screening neuroprotective compounds in herpes-induced Alzheimer’s disease cell and 3D tissue models
- Silveira et al. Free Radic Biol Med 186: 76 (2022).
- Bioengineered models of Parkinson’s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment
- Fiore et al. Cell Mol Life Sci 79: 78 (2022).
- A 3D human brain-like tissue model of herpes-induced Alzheimer’s disease.
- Cairns et al. Sci Adv 6: eaay8828 (2020).
- A long-living bioengineered neural tissue platform to study neurodegeneration.
- Rouleau et al. Macromol Biosci. 20: e202000004 (2020).
- Functional and sustainable 3D human neural network models from pluripotent stem cells.
- Cantley et al. ACS Biomater Sci Eng. 4: 4278 (2018).
- See more of our publications on neurodegenerative diseases >>
Traumatic Brain Injury
- Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model.
- Cairns et al. Sci Signal 18: eado6430 (2025).
- 3D Neurovascular Unit Tissue Model to Assess Responses to Traumatic Brain Injury.
- Power et al. J Biomed Mater Res A 113: e37816 (2025).
- Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.
- Liaudanskaya et al. Cell Death Dis 14: 496 (2023).
- Development of a novel bioengineered 3D brain-like tissue for studying primary blast-induced traumatic brain injury.
- Snapper et al. J Neurosci Res 101: 3 (2023).
- A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure to gabapentinoids.
- Rouleau et al. Biomolecules 10: 1196 (2020).
- Modeling controlled cortical impact injury in 3D brain-like tissue cultures.
- Liaudanskaya et al. Adv Healthc Mater 9: e2000122 (2020).
- Time-dependent changes in microglia transcriptional networks following traumatic brain injury.
- Izzy et al. Front Cell Neurosci. 13: 307 (2019).
- Film interface for drug testing for delivery to cells in culture and in the brain.
- Tang-Schomer et al. Acta Biomater. 94: 306 (2019).
- Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.
- Liu et al. Biomaterials 116: 34 (2017).
- See more of our publications on traumatic brain injury >>
Cancer
- Enhancing sustained-release local therapy: single versus dual chemotherapy for the treatment of neuroblastoma.
- Taylor et al. Surgery 167: 969 (2020).
- 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
- Sood et al. Nat Commun. 10: 4529 (2019).
- Silk reservoirs for local delivery of cisplatin for neuroblastoma treatment: in vitro and in vivo evaluations.
- Yavuz et al. J Pharm Sci. 108: 2748 (2019).
- In vitro and in vivo evaluation of etoposide – silk wafers for neuroblastoma treatment.
- Yavuz et al. J Control Release 285: 162 (2018).
- Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment.
- Coburn et al. Int J Cancer 140: 726 (2017).
- See more of our publications on cancer >>
Regenerative Medicine
- Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats.
- Liaudanskaya et al. Biomaterials 192: 510 (2019).
- In vitro 3D regeneration-like growth of human patient brain tissue.
- Tang-Schomer et al. J Tissue Eng Regen Med. 12: 1247 (2018).
- See more of our publications on regenerative medicine >>
Neural Mechanisms of Learning & Cognition
- Learning and synaptic plasticity in 3D bioengineered neural tissues.
- Rouleau et al. Neurosci Lett 750: 135799 (2021).
- Toward studying cognition in a dish.
- Rouleau et al. Trends Cogn Sci 25: 294 (2021).
- On the generalization of habituation: how discrete biological systems respond to repetitive stimuli.
- Bonzanni et al. Bioessays 41: e1900028 (2019).
- See more of our publications on neural mechanisms of learning & cognition >>
Imaging & Analysis of Neuronal Systems
- Synergistic label-free fluorescence imaging and miRNA studies reveal dynamic human neuron-glial metabolic interactions following injury.
- Zhang et al. Sci Adv 10: eadp1980 (2024).
- On the effect of neuronal spatial subsampling in small-world networks.
- Bonzanni et al. Eur J Neurosci 53: 485 (2021).
- Endogenous two-photon excited fluorescence imaging characterizes neuron and astrocyte metabolic responses to manganese toxicity.
- Stuntz et al. Sci Rep. 7: 1041 (2017).
- Tutorials for electrophysiological recordings in neuronal tissue engineering.
- Du et al. ACS Biomater Sci Eng 3: 2235 (2017).
- See more of our publications on imaging & analysis of neuronal systems >>
Additional Diseases & Related Areas of Investigation
- Matrix deformation with ectopic cells induced by rotational motion in bioengineered neural tissues.
- Rouleau et al. Ann Biomed Eng 48: 2192 (2020).
- Defined extracellular ionic solutions to study and manipulate the cellular resting potential.
- Bonzanni et al. Biol Open 9: bio048553 (2020).
- Ivermectin promotes peripheral nerve regeneration during wound healing.
- Cairns et al. ACS Omega 3: 12392 (2018).
- Tissue models for neurogenesis and repair in 3D.
- Grasman et al. Adv Funct Mater. 28: 1803822 (2018).
- Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells.
- Cairns et al. Biol Open 7: bio031807 (2018).
- Film-based implants for supporting neuron-electrode integrated interfaces for the brain.
- Tang-Schomer et al. Adv Funct Mater. 24: 1938 (2014).
- See more of our publications on additional diseases and related areas of investigation >>