The focus of INSciDE @ Tufts is on developing 3D in vitro tissue models of the human brain and peripheral nervous system to study structure, function, and diseases. We integrate bioengineering, stem cell biology and regenerative medicine with tools and technologies such as optical imaging, electrophysiology, and pharmacology to evaluate tissue models and begin to unravel the mechanisms of cognition and uncover cures for neurological disorders.

 

Current Projects:

 

Human Stem Cell Derived 3D Neural Network Tissue Model

 

Generation of Physiological 3D in vitro Brain Cultures using Bioinspired Matrix for Disease Modeling

 

3D Bioengineered Model of Human Enteric Nervous System

 

3D In Vitro Autism Spectrum Disorder Model

 

Traumatic Brain Injuries: Advanced Model Engineering, Fundamental Understanding of the Molecular Mechanisms, and Replacement Therapy

 

3D In Vitro Blood-Brain Barrier Tissue Model

 

Behavioral Paradigms in Three-Dimensional Neural Tissue Constructs Coupled to Motor Effectors