Selected Research Publications:
3D Models of Neurodegenerative Diseases:
Functional bioengineered tissue models of neurodegenerative diseases.
Mullis and Kaplan. Biomaterials 298: 122143 (2023).
A long-living bioengineered neural tissue platform to study neurodegeneration.
Rouleau et al. Macromol Biosci 20: e2000004 (2020).
A 3D human brain-like tissue model of herpes-induced Alzheimer’s disease.
Cairns et al. Sci Adv 6: eaay8828 (2020).
Functional and sustainable 3D human neural network models from pluripotent stem cells.
Cantley et al. ACS Biomater Sci Eng 4: 4278 (2018).
Alzheimer’s Disease and other dementias:
Potential Involvement of Varicella Zoster Virus in Alzheimer’s Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1.
Cairns et al. J Alzheimers Dis 88: 1189 (2022).
Screening neuroprotective compounds in herpes-induced Alzheimer’s disease cell and 3D tissue models.
Silveira et al. Free Radic Biol Med. 186: 76 (2022).
BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
Kim et al. Mol Neurodegener. 13: 6 (2018).
Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer’s disease.
Biscaro et al. Neurodegener Dis. 9: 187 (2012).
Mechanisms of enzymatic degradation of amyloid β microfibrils generating nanofilaments and nanospheres related to cytotoxicity.
Numata and Kaplan. Biochemistry 49: 3254 (2010).
Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
Kim et al. Hum Mol Genet. 18: 3987 (2009).
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Tesco G et al. Neuron 54: 721 (2007).
Parkinson’s Disease:
3D biocomposite culture enhances differentiation of dopamine-like neurons from SH-SY5Y cells: A model for studying Parkinson’s disease phenotypes.
Fiore et al. Biomaterials 290: 121858 (2022).
Bioengineered models of Parkinson’s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment
Fiore et al. Cell Mol Life Sci 79: 78 (2022).
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
Kitada et al. J Neurochem 110: 613 (2009).
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Tong et al. PNAS 106: 14622 (2009).