Our focus is on PTMs that have been particularly difficult to study using traditional tools, which typically inhibit or profile specific enzyme activities. In particular, we address this problem through the development of new, selective chemical methods that can predictably modulate and/or report on PTM function. These methods will be used to address longstanding questions about the role of vital, yet elusive, PTMs in inflammation, bacterial infection, autoimmune disease, cancer, as well as metabolic and age-related diseases.
The ongoing projects in our lab are divided into three main research areas, and are described in further detail below:
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