The Garlick Lab studies the interface between tissue engineering and stem cell biology to advance regenerative therapies. The lab creates 3D, skin-like tissues constructed from cells derived from patient-derived cells to study cell behavior in a biologically-relevant tissue context. Our goal is to create skin-like tissues that can accelerate the translation of drug discovery for both Scleroderma and Diabetic Foot Ulcers.
The Garlick lab holds programs that invite the public and students to participate in science. We have hosted groups as part of the Cambridge Science Festival (“The Wonderful World of Stem Cells”) and develop collaborative programs with the Museum of Science. Our lab mentors students from diverse backgrounds through programs with U Mass Boston and Roxbury Community College, where Dr. Garlick serves on their Science Department Advisory Board.
Smith,A., Huang,M., Watkins,T., Burguin,F., Baskin, J.,,Garlick, J., De novo production of human extracellular matrix supports increased throughput and cellular complexity in 3D skin equivalent model. Journal of Tissue Engineering and Regenerative Medicine, (June 2020).
Quantina, P.,Ghazia, P., Pereira, U., Smith, A., Degardin, L.,Vignerona, P.,Ficheuxa, H.,Garlick, J.,Rapettib, L.,Egles C., (April 2020). Utilization of a mouse/human chimeric model for long term metabolic testing of human skin. J Pharmacol Toxicol Methods, 102:106663. doi: 10.1016/j.vascn.2019.106663.
Garlick, J.A.., Soisson, A., Bergom, I., Design and Impact of an Undergraduate Civic Science Course. Journal of College Science Teaching, Volume 49, Issue 4, (March/April 2020).
Huang, M., Cai, G., Baugh, LM., Liu, Z., Smith, A., Watson, M., Popovich, D., Zhang, T., Stawski, LS., Trojanowska, M., Georgakoudi, I., Black, LD., Pioli, PA., Whitfield, ML., Garlick, J., (Nov 2019), Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues. Arthritis Rheumatol. doi: 10.1002/art.41163
Kashpur, O., Smith, A., Gerami-Naini, B., Maione, A. G., Calabrese, R., Tellechea, A., Garlick, J. A. (2019). Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes. FASEB Journal, 33(1), 1262-1277. doi:10.1096/fj.201801059
Huang, M., Liu,Z., Baugh,L., DeFuria,J., Maione, A., Smith, A., Kashpur,O., Black,LD., Georgakoudi,I., Whitfield, ML., Garlick, J., (April, 2019), Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. Lab Invest. 99(4):514-527. doi: 10.1038/s41374-018-0159-8.