TransCelerate’s interactive Personalized Clinical Trials Framework is a set of practical considerations to support the R&D ecosystem (i.e., sponsors, sites, third parties, and other clinical trial stakeholders) with understanding and evaluating options that enable a more personalized experience for clinical trial participants across diverse populations. The framework provides fourteen potential opportunities to enable personal choice into a clinical trial, and includes considerations to help action the opportunity, potential value and benefits, as well as tools and resources to support implementation.