This toolkit is a supplement to the white paper examining barriers to clinical study participation among executive leaders, providers, and medical staff at community health centers (CHCs) nationally. The toolkit’s purpose is to provide CHCs with an overview of study options and guidance on how to participate in a variety of studies, either directly or indirectly. The aim is to demonstrate CHCs’ potential to engage at any desired level in clinical studies of all types. Neighborhood Healthcare, a CHC grantee, and Altura, the project manager and lead advisory collaborated to initiate and execute this project, made possbile by a Health Equity and Diversity Grant from Genenetch, a member of the Roche Group.