Jacob-Dolan, Jeremiah W., Sterling, Amy C., Brutus, Morgan E. Hansel, Stefan M., and Scheck, Rebecca A.* Discovery of Glycation-Derived Crosslinks at Arginine Journal of the American Chemical Society (in revision) available on BioRxiv!
Discovery of Glycation-Derived Crosslinks at Arginine
Brutus, Morgan E., Girard, Colby S., Jacob-Dolan, Jeremiah W., and Scheck, Rebecca A.* A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product. (submitted) available on BioRxiv!
A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product
Pham, Vo Tri Tin, Datta, Suprama, Sterling, Amy C., Hansel, Stefan M., and Scheck, Rebecca A.*, A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine. Journal of the American Chemical Society (accepted)
A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine
Eckhard, Julia Fee, Scheck, Rebecca A., and Caspari, Ira*, Enhancing Students’ Agency and Coherence in Organic Chemistry through Transformed Problem Design. Chemistry Education Research and Practice (2025) doi: 10.1039/D5RP00268K
Enhancing Students’ Agency and Coherence in Organic Chemistry through Transformed Problem Design.
Martin, Meghan S., Jacob-Dolan, Jeremiah W., Pham, Vo Tri Tin, Sjoblom, Nicole M., and Scheck, Rebecca A.* The chemical language of protein glycation. Nature Chemical Biology (2025) 21, 324-336 https://doi.org/10.1038/s41589-024-01644-y
Kotewicz, Kristin M., Zhang, Mengyun., Kim, Seongok., Martin, Meghan S., Choudhary, Atish Roy., Tai, Albert., Scheck, Rebecca A., and Isberg, Ralph R.* Sde proteins coordinate ubiquitin utilization and phosphoribosylation to establish and maintain the Legionella replication vacuole. Nature Communications (2024) 15 article 7479. DOI https://doi.org/10.1038/s41467-024-51272-2
Hill, Caitlin J.†, Datta, Suprama†, McCurtin, Nicholas P., Kimball, Hannah Z., Kingsley Molly C., Bayer, Abraham L., Martin, Alexander C., Peng, Qianni, Weerapana, Eranthie, and Scheck, Rebecca A.* A Modular Turn-On Strategy to Profile E2-Specific Ubiquitination Events in Living Cells. Angewandte Chemie International Edition (2024) 63 (13), e202319579. https://doi.org/10.1002/anie.202319579†equal contribution
A Modular Turn-On Strategy to Profile E2-Specific Ubiquitination Events in Living Cells
Lahiri, Priyanka, Martin, Meghan S., Lino, Briana R., Scheck, Rebecca A., and Van Deventer, James A.* Dual Noncanonical Amino Acid Incorporation Enabling Chemoselective Protein Modification at Two Distinct Sites in Yeast. Biochemistry (2023) 62 (14), pp. 2098–2114 https://doi.org/10.1021/acs.biochem.2c00711
Dual Noncanonical Amino Acid Incorporation Enabling Chemoselective Protein Modification at Two Distinct Sites in Yeast
Gao, Qingzeng, Jacob-Dolan, Jeremiah W., and Scheck, Rebecca A.. Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation. Biochemistry (2023) 62 (6), pp. 1181–1190 https://doi.org/10.1021/acs.biochem.3c00028
Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation
Zhang, Mengyun.†, McEwen, Joseph M.†, Sjoblom, Nicole M., Kotewicz, Kristin M., Isberg, Ralph R.* and Scheck, Rebecca A.*. Members of the Legionella pneumophila Sde Family Target Tyrosine Residues for Phosphoribosyl-Linked Ubiquitination. RSC Chemical Biology (2021) 2 pp. 1509-1519. DOI https://doi.org/10.1039/D1CB00088H †equal contribution, *co-corresponding
Members of the Legionella pneumophila Sde Family Target Tyrosine Residues for Phosphoribosyl Linked Ubiquitination
Chambers, Kaitlin A. and Scheck, Rebecca A. Bacterial virulence mediated by orthogonal post-translational modification. Nature Chemical Biology (2020) 16, pp 1043–1051. https://doi.org/10.1038/s41589-020-0638-2
Bacterial virulence mediated by orthogonal post-translational modification
Chambers, Kaitlin A., Abularrage, Nile S., Hill, Caitlin J., Khan, Imran H., and Scheck, Rebecca A. A chemical probe for dehydrobutyrine. Angewandte ChemieInternational Edition (2020) 59 (19), pp 7350-7355. https://doi.org/10.1002/anie.202003631
Sjoblom, Nicole M., Kelsey, Maxfield M.G., and Scheck, Rebecca A. A systematic study of protein glycation. Angewandte Chemie International Edition (2018) 57 (49), pp 16077-1608. https://doi.org/10.1002/anie.201810037
Chambers, Kaitlin A., Abularrage, Nile S., and Scheck, Rebecca A. Selectivity within a family of bacterial phosphothreonine lyases. Biochemistry (2018) 57 (26), pp 3790–3796. https://doi.org/10.1021/acs.biochem.8b00534
Selectivity within a family of bacterial phosphothreonine lyases
Kotewicz, Kristin, M., Ramabhadran, Vinay, Sjoblom, Nicole, Haenssler, Eva, Zhang,Mengyung, Scheck, Rebecca A.,and Isberg, Ralph R. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe (2017) 21(2), pp 169-181. https://doi.org/10.1016/j.chom.2016.12.007
A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication
Doerner, Amy E., Scheck, Rebecca A., Schepartz, Alanna. Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region. Chemistry & Biology (2015) 22(6), pp 776-784.
Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region
Scheck, Rebecca A., Lowder, Melissa A., Appelbaum, Jacob S., and Schepartz, Alanna. Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. ACS Chemical Biology (2012)
7(8), pp 1367-1376.
Scheck, Rebecca A. and Schepartz, Alanna. Surveying protein structure and function using bis-arsenical small molecules. Accounts of Chemical Research (2011) 44(9), pp 654–665.
Surveying protein structure and function using bis-arsenical small molecules
Witus, Leah S., Moore, Troy., Thuronyi, Benjamin W., Esser-Kahn, Aaron P., Scheck, Rebecca A., Iavarone, Anthony, T., and Francis, Matthew B. Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library. Journal of the American Chemical Society (2010) 132(47), pp 16812–16817.
Scheck, Rebecca A., Dedeo, Michel, T., Iavarone, Anthony, T., and Francis, Matthew B. Optimization of a biomimetic transamination reaction. Journal of the American Chemical Society (2008), 130(35), pp 11762–11770.
Optimization of a biomimetic transamination reaction
Scheck, Rebecca A., Francis, Matthew B. Regioselective labeling of antibodies through N-terminal transamination. ACS Chemical Biology (2007), 2(4), pp 247-251.
Regioselective labeling of antibodies through N-terminal transamination
Tulevski, George S., Miao, Qian., Fukuto, Masafumi, Abram, Rebecca, Ocko, Benjamin, Pindak, Ronald, Steigerwald, Michael L., Kagan, Cherle R., Nuckolls, Colin. Attaching organic semiconductors to gate oxides: In situ assembly of monolayer field effect transistors. Journal of the American Chemical Society (2004), 126(46), pp 15048-15050.
Attaching organic semiconductors to gate oxides: In situ assembly of monolayer field effect transistors