Publications
25
Jacob-Dolan, Jeremiah W., Sterling, Amy C., Brutus, Morgan E. Hansel, Stefan M., and Scheck, Rebecca A.* Discovery of Glycation-Derived Crosslinks at Arginine Journal of the American Chemical Society (in revision) available on BioRxiv!
Discovery of Glycation-Derived Crosslinks at Arginine
24
Brutus, Morgan E., Girard, Colby S., Jacob-Dolan, Jeremiah W., and Scheck, Rebecca A.* A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product. (submitted) available on BioRxiv!
A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product
23
Pham, Vo Tri Tin, Datta, Suprama, Sterling, Amy C., Hansel, Stefan M., and Scheck, Rebecca A.*, A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine. Journal of the American Chemical Society (accepted)
A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine
22
Eckhard, Julia Fee, Scheck, Rebecca A., and Caspari, Ira*, Enhancing Students’ Agency and Coherence in Organic Chemistry through Transformed Problem Design. Chemistry Education Research and Practice (2025) doi: 10.1039/D5RP00268K
Enhancing Students’ Agency and Coherence in Organic Chemistry through Transformed Problem Design.
21
Predictable Modulation of a Spontaneous Post-translational Modification in Living Cells
20
Martin, Meghan S., Jacob-Dolan, Jeremiah W., Pham, Vo Tri Tin, Sjoblom, Nicole M., and Scheck, Rebecca A.* The chemical language of protein glycation. Nature Chemical Biology (2025) 21, 324-336 https://doi.org/10.1038/s41589-024-01644-y
The chemical language of protein glycation
19
Kotewicz, Kristin M., Zhang, Mengyun., Kim, Seongok., Martin, Meghan S., Choudhary, Atish Roy., Tai, Albert., Scheck, Rebecca A., and Isberg, Ralph R.* Sde proteins coordinate ubiquitin utilization and phosphoribosylation to establish and maintain the Legionella replication vacuole. Nature Communications (2024) 15 article 7479. DOI https://doi.org/10.1038/s41467-024-51272-2
Sde proteins coordinate ubiquitin utilization and phosphoribosylation to establish and maintain the Legionella replication vacuole.
18
Hill, Caitlin J.†, Datta, Suprama†, McCurtin, Nicholas P., Kimball, Hannah Z., Kingsley Molly C., Bayer, Abraham L., Martin, Alexander C., Peng, Qianni, Weerapana, Eranthie, and Scheck, Rebecca A.* A Modular Turn-On Strategy to Profile E2-Specific Ubiquitination Events in Living Cells. Angewandte Chemie International Edition (2024) 63 (13), e202319579. https://doi.org/10.1002/anie.202319579 †equal contribution
A Modular Turn-On Strategy to Profile E2-Specific Ubiquitination Events in Living Cells
17
Lahiri, Priyanka, Martin, Meghan S., Lino, Briana R., Scheck, Rebecca A., and Van Deventer, James A.* Dual Noncanonical Amino Acid Incorporation Enabling Chemoselective Protein Modification at Two Distinct Sites in Yeast. Biochemistry (2023) 62 (14), pp. 2098–2114 https://doi.org/10.1021/acs.biochem.2c00711
Dual Noncanonical Amino Acid Incorporation Enabling Chemoselective Protein Modification at Two Distinct Sites in Yeast
16
Gao, Qingzeng, Jacob-Dolan, Jeremiah W., and Scheck, Rebecca A.. Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation. Biochemistry (2023) 62 (6), pp. 1181–1190 https://doi.org/10.1021/acs.biochem.3c00028
Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation
15
Zhang, Mengyun.†, McEwen, Joseph M.†, Sjoblom, Nicole M., Kotewicz, Kristin M., Isberg, Ralph R.* and Scheck, Rebecca A.*. Members of the Legionella pneumophila Sde Family Target Tyrosine Residues for Phosphoribosyl-Linked Ubiquitination. RSC Chemical Biology (2021) 2 pp. 1509-1519. DOI https://doi.org/10.1039/D1CB00088H †equal contribution, *co-corresponding
Members of the Legionella pneumophila Sde Family Target Tyrosine Residues for Phosphoribosyl Linked Ubiquitination
14
McEwen, Joseph M., Fraser, Sasha, Sosa Guir, Alexxandra, Dave, Jaydev, and Scheck, Rebecca A. Synergistic sequence contributions bias glycation outcomes Nature Communications (2021) 12, 3316 pp. 1-10. https://doi.org/10.1038/s41467-021-23625-8
Synergistic sequence contributions bias glycation outcomes
13
Chambers, Kaitlin A. and Scheck, Rebecca A. Bacterial virulence mediated by orthogonal post-translational modification. Nature Chemical Biology (2020) 16, pp 1043–1051. https://doi.org/10.1038/s41589-020-0638-2
Bacterial virulence mediated by orthogonal post-translational modification
12
Chambers, Kaitlin A., Abularrage, Nile S., Hill, Caitlin J., Khan, Imran H., and Scheck, Rebecca A. A chemical probe for dehydrobutyrine. Angewandte Chemie International Edition (2020) 59 (19), pp 7350-7355. https://doi.org/10.1002/anie.202003631
A chemical probe for dehydrobutyrine
11
Sjoblom, Nicole M., Kelsey, Maxfield M.G., and Scheck, Rebecca A. A systematic study of protein glycation. Angewandte Chemie International Edition (2018) 57 (49), pp 16077-1608. https://doi.org/10.1002/anie.201810037
A systematic study of protein glycation
10
Chambers, Kaitlin A., Abularrage, Nile S., and Scheck, Rebecca A. Selectivity within a family of bacterial phosphothreonine lyases. Biochemistry (2018) 57 (26), pp 3790–3796. https://doi.org/10.1021/acs.biochem.8b00534
Selectivity within a family of bacterial phosphothreonine lyases
9
Kotewicz, Kristin, M., Ramabhadran, Vinay, Sjoblom, Nicole, Haenssler, Eva, Zhang,Mengyung, Scheck, Rebecca A.,and Isberg, Ralph R. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe (2017) 21(2), pp 169-181. https://doi.org/10.1016/j.chom.2016.12.007
A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication
Prior to Tufts
8
Doerner, Amy E., Scheck, Rebecca A., Schepartz, Alanna. Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region. Chemistry & Biology (2015) 22(6), pp 776-784.
Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region
7
Scheck, Rebecca A., Lowder, Melissa A., Appelbaum, Jacob S., and Schepartz, Alanna. Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. ACS Chemical Biology (2012)
7(8), pp 1367-1376.
Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation
6
Scheck, Rebecca A. and Schepartz, Alanna. Surveying protein structure and function using bis-arsenical small molecules. Accounts of Chemical Research (2011) 44(9), pp 654–665.
Surveying protein structure and function using bis-arsenical small molecules
5
Witus, Leah S., Moore, Troy., Thuronyi, Benjamin W., Esser-Kahn, Aaron P., Scheck, Rebecca A., Iavarone, Anthony, T., and Francis, Matthew B. Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library. Journal of the American Chemical Society (2010) 132(47), pp 16812–16817.
Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library
4
Scheck, Rebecca A., Dedeo, Michel, T., Iavarone, Anthony, T., and Francis, Matthew B. Optimization of a biomimetic transamination reaction. Journal of the American Chemical Society (2008), 130(35), pp 11762–11770.
Optimization of a biomimetic transamination reaction
3
Scheck, Rebecca A., Francis, Matthew B. Regioselective labeling of antibodies through N-terminal transamination. ACS Chemical Biology (2007), 2(4), pp 247-251.
Regioselective labeling of antibodies through N-terminal transamination
2
Gilmore, Joshua M.†, Scheck, Rebecca A.†, Joshi, Neel S., Francis, Matthew B. N-terminal protein modification through a biomimetic transamination reaction. Angewandte Chemie-International Edition (2006),
45(32), pp 5307-5311. †equal contribution
N-terminal protein modification through a biomimetic transamination reaction
1
Tulevski, George S., Miao, Qian., Fukuto, Masafumi, Abram, Rebecca, Ocko, Benjamin, Pindak, Ronald, Steigerwald, Michael L., Kagan, Cherle R., Nuckolls, Colin. Attaching organic semiconductors to gate oxides: In situ assembly of monolayer field effect transistors. Journal of the American Chemical Society (2004), 126(46), pp 15048-15050.